Results 51 to 60 of about 348,762 (206)
Advanced Science, EarlyView.Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao +13 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.These results demonstrate that mixotrophic conditions drive both microbial community shifts and metabolic reprogramming, underscoring the importance of cultivation strategy and polyculture selection for targeted applications such as nutrient recovery and bioproduct generation.
Quyen Nham +3 more
wiley +1 more source
Chronic Diseases and Translational Medicine, EarlyView.Flowchart of patient enrollment. ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with hyperhomocysteinemia (HHcy).
Xiaohui Dou +8 more
wiley +1 more source
Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase. [PDF]
PLoS ONE, 2014 Nitrite was recognized as a potent vasodilator >130 years and has more recently emerged as an endogenous signaling molecule and modulator of gene expression. Understanding the molecular mechanisms that regulate nitrite metabolism is essential for its use
Carmen Gherasim +4 more
doaj +1 more source
International Journal of Neonatal Screening, 2021 Neonatal screening (NS) for methylmalonic acidemia uses propionylcarnitine (C3) as a primary index, which is insufficiently sensitive at detecting methylmalonic acidemia caused by defects in the adenosylcobalamin synthesis pathway.
Reiko Kagawa +12 more
doaj +1 more source
Human ATP:Cob(I)alamin Adenosyltransferase and Its Interaction with Methionine Synthase Reductase [PDF]
Journal of Biological Chemistry, 2004 The final step in the conversion of vitamin B(12) into coenzyme B(12) (adenosylcobalamin, AdoCbl) is catalyzed by ATP:cob(I)alamin adenosyltransferase (ATR). Prior studies identified the human ATR and showed that defects in its encoding gene underlie cblB methylmalonic aciduria.
Nicole A, Leal +3 more
openaire +2 more sources
Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation. [PDF]
PLoS ONE, 2015 Aspergillus flavipes has received considerable interest due to its potential to produce therapeutic enzymes involved in sulfur amino acid metabolism. In natural habitats, A.
Ashraf S A El-Sayed +2 more
doaj +1 more source
Современная ревматология, 2021 Clinical response to methotrexate (MT) therapy in rheumatoid arthritis (RA) can be predicted on the basis of some single nucleotide polymorphisms (SNPs) of genes, involved in folate metabolism.
M. Yu. Krylov +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil
Brazilian Journal of Medical and Biological Research, 2007 Non-syndromic cleft lip and palate (CL/P) occurs due to interaction between genetic and environmental factors. Abnormalities in homocysteine metabolism may play a role in its etiology due to polymorphisms in genes involved in this pathway. Because of the
A.P.C. Brandalize +5 more
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