Results 11 to 20 of about 3,923,906 (342)

Alternative methods in toxicology: pre-validated and validated methods [PDF]

Interdisciplinary Toxicology, 2011
The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds.
Kandárová, Helena, Letašiová, Silvia
openaire   +2 more sources

Application of Contemporary Extraction Techniques for Elements and Minerals Recovery from Stinging Nettle Leaves

Applied Sciences, 2020
Stinging nettle (Urtica dioica L.) is a perennial plant belonging to the Urticaceae family. Several studies have reported the presence of the different classes of chemical compounds, which expressed a beneficial effect on human health.
Saša Popov, Suzana Skeledžija, Saša Šorgić, Zoran Zeković, Darko Micić, Aleksandra Radulović, Saša Đurović   +6 more
doaj   +1 more source

A Validated RP-HPLC Method for the Simultaneous Detection and Quantification of Pyridoxine and Terizidone in Pharmaceutical Formulations

Analytica, 2021
Tuberculosis (TB) remains a life-threatening infection, and it is well-known that effective TB treatment is associated with multiple drugs administered to infected patients on a daily basis.
Ngabo Yves Musafili, Halima Samsodien, Marique Elizabeth Aucamp   +2 more
doaj   +1 more source

Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine

Nanomaterials, 2020
Herein, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective
Saad S.M. Hassan, Ayman H. Kamel, Abd El-Galil E. Amr, Heba M. Hashem, E.M. Abdel Bary   +4 more
doaj   +1 more source

Intra-Laboratory Validation of Alpha-Galactosidase Activity Measurement in Dietary Supplements

Molecules, 2021
Introduction: Alpha-galactosidase (α-Gal) is an enzyme responsible for the hydrolyzation of glycolipids and glycoprotein commonly found in dietary sources.
Elena Fabris, Michela Bulfoni, Alessandro Nencioni, Emanuele Nencioni   +3 more
doaj   +1 more source

Systems validation: application to statistical programs [PDF]

, 2005
BACKGROUND: In 2003, the United States Food and Drug Administration (FDA) released a guidance document on the scope of "Part 11" enforcement. In this guidance document, the FDA indicates an expectation of a risk-based approach to determining which ...
D Moher, FDA, FDA, Rickey E Carter, T Stokes, T Stokes   +5 more
core   +3 more sources

Development of HPLC Method for Quantification of Sinigrin from Raphanus sativus Roots and Evaluation of Its Anticancer Potential

Molecules, 2020
Sinigrin, a precursor of allyl isothiocyanate, present in the Raphanus sativus exhibits diverse biological activities, and has an immense role against cancer proliferation.
Anroop B. Nair, Dipal Gandhi, Snehal S. Patel, Mohamed A. Morsy, Bapi Gorain, Mahesh Attimarad, Jigar N. Shah   +6 more
doaj   +1 more source

Detection of Nitrated, Oxygenated and Hydrogenated Polycyclic Aromatic Compounds in Smoked Fish and Meat Products

Foods, 2022
Polycyclic aromatic hydrocarbons (PAHs) are present in smoked food products. More toxic nitrated (NPAH) and oxygenated (OPAH) PAHs derivatives are found concomitantly to PAHs and are therefore believed to be found in smoked food products. However, only a
Elisa Sonego, Bina Bhattarai, Lene Duedahl-Olesen   +2 more
doaj   +1 more source

Development and Validation of a Bioanalytical Method for 3′- and 6′-Sialyllactose in Minipig Liver and Kidney Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Analysis of Tissue Distribution

Molecules, 2020
Breast milk contains human milk oligosaccharides (HMOs), including sialyllactose (SL). SL is composed of sialic acid and lactose, and is divided into 3′-SL and 6′-SL according to the binding position.
Han Young Eom, Seok-In Jang, Jong-Hwa Lee   +2 more
doaj   +1 more source

Authenticity Analysis of Cold-Pressed Orange Essential Oils by GC/MS on Polymethoxyflavone Components

Agriculture, 2023
Citrus essential oil combines numerous components with many qualities and control issues. For example, how to monitor volatile components and nonvolatile substances simultaneously is a major problem.
Kai-Min Yang, Chih-Wei Chen, Min-Hung Chen, Hsin-Chun Chen, Li-Yun Lin   +4 more
doaj   +1 more source