Results 51 to 60 of about 3,918,910 (289)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Non-Targeted Nuclear Magnetic Resonance Analysis for Food Authenticity: A Comparative Study on Tomato Samples

Molecules
Non-targeted NMR is widely accepted as a powerful and robust analytical tool for food control. Nevertheless, standardized procedures based on validated methods are still needed when a non-targeted approach is adopted.
Biagia Musio, Rosa Ragone, Stefano Todisco, Antonino Rizzuti, Egidio Iorio, Mattea Chirico, Maria Elena Pisanu, Nadia Meloni, Piero Mastrorilli, Vito Gallo   +9 more
doaj   +1 more source

A critical rationalist approach to organizational learning: testing the theories held by managers [PDF]

, 2011
The common wisdom is that Popper's critical rationalism, a method aimed at knowledge validation through falsification of theories, is inadequate for managers in organizations.
Faran, Doron, Wijnhoven, Fons
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analytical Evaluation of the Autobio 25-OH Vitamin D Assay: Comparison with Liquid Chromatography–Tandem Mass Spectrometry and Clinical Implications

Metabolites
Background: 25-Hydroxy vitamin D [25(OH)D] is the circulating form of vitamin D. Its deficiency is a major global health concern, affecting over one billion people. Beyond its role in bone health, low vitamin D levels have been implicated in a wide range
Flaminia Tomassetti, Eleonora Nicolai, Martina Pelagalli, Federico Cortese, Alfredo Giovannelli, Sabrina Ballerini, Alessia Mozzi, Anastasia De Luca, Massimo Pieri, Sergio Bernardini   +9 more
doaj   +1 more source

Development and Validation of a Simple and Sensitive LC-MS/MS Method for Quantification of Metformin in Dried Blood Spot Its Application as an Indicator for Medication Adherence

International Journal of General Medicine, 2021
Bushra T ALquadeib,1,* Nouf M Aloudah,2,* Alanood S Almurshedi,1 Iman M ALfagih,1 Basmah N ALdosari,1 Adim S ALmeleky,3 Nour M Almubyedh3 1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11671, Saudi Arabia ...
ALquadeib BT, Aloudah NM, Almurshedi AS, ALfagih IM, ALdosari BN, ALmeleky AS, Almubyedh NM   +6 more
doaj  

A GCV based Arnoldi-Tikhonov regularization method

, 2013
For the solution of linear discrete ill-posed problems, in this paper we consider the Arnoldi-Tikhonov method coupled with the Generalized Cross Validation for the computation of the regularization parameter at each iteration.
Novati, Paolo, Russo, Maria Rosaria
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Absorption, Distribution, Excretion, and In Vitro Hepatic Microsomal Metabolism of the Novel CDK Compound XMD12 in Sprague-Dawley Rats

Pharmaceutics
Background: Cyclin-dependent kinase 4/6 (CDK4/6) represents one of the clinically validated and therapeutically effective anticancer targets. Methods: This study established a rapid and sensitive HPLC-MS/MS method for quantitative determination of XMD12,
Xue-Hai Zheng, Yan-Chun Chang, Yong-Hui Li, Yu-Xia He, Pei-Xiong Zhao, Fei-Fei Wang, Jun-Yu Xu, Yin-Feng Tan   +7 more
doaj   +1 more source

Validated HPLC method for quantification of copanlisib in mice plasma: application to a pharmacokinetic study

ADMET and DMPK, 2020
Copanlisib is a pan phosphatidylinositol 3-kinase (PI3K) inhibitor approved for follicular lymphoma. In this paper, we present the data of development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of ...
Ashok Zakkula, Pavan Kumar Kurakula, Sreekanth Dittakavi, Prasanthi Daram, Ram Murthi Bestha, Mohd Zainuddin, Ravi Kumar Trivedi, Ramesh Mullangi   +7 more
doaj   +1 more source