Results 101 to 110 of about 8,171,446 (309)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Systematic Reviews Comparing Direct and Indirect Restorations: An Umbrella Review That Examines Restoration Type and Confidence in Results

Clinical and Experimental Dental Research
Objectives There are two technologies for restoring individual structurally defective teeth. A direct restoration is applied chairside in one appointment, while an indirect restoration needs to be lab‐produced before application.
Mona Kimmel, Clovis Mariano Faggion Jr.
doaj   +1 more source

Conditions of The Life Quality – Methodological Remarks [PDF]

Economic and Environmental Studies, 2017
Jakość życia jest rezultatem stopnia zaspokojenia potrzeb co wynika m.in. z konsumpcji dóbr i usług. Celem pracy jest upowszechnienie wyników prób poszukiwania przez autorkę determinant jakości życia z wykorzystaniem bardziej zaawansowanych metod statystycznych, które przy np.
openaire   +3 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Quality Improvement Division Operations Plan 2018

, 2018
This is the Operational Plan for the Quality Improvement Division (QID) for 2018 and builds on the work done since 2015 to enable the HSE develop and implement a quality improvement agenda and capability across all levels of the ...
Quality Improvement Division
core  

Real‐world evaluation of interconsensus agreement of risk of bias tools: A case study using risk of bias in nonrandomized studies‐of interventions (ROBINS‐I)

Cochrane Evidence Synthesis and Methods
Background Risk of bias (RoB) tools are critical in systematic reviews and affect subsequent decision‐making. RoB tools should have adequate interrater reliability and interconsensus agreement.
Samer Saadi, Bashar Hasan, Adel Kanaan, Mohamed Abusalih, Zin Tarakji, Mustafa Sadek, Ayla Shamsi Basha, Mohammed Firwana, Zhen Wang, M. Hassan Murad   +9 more
doaj   +1 more source

High-dose thalidomide increases the risk of peripheral neuropathy in the treatment of ankylosing spondylitis

Neural Regeneration Research, 2015
Thalidomide is an effective drug for the treatment of ankylosing spondylitis but might induce peripheral neuropathy. This major adverse reaction has attracted much concern.
Hong-xia Xue, Wen-yi Fu, Hua-dong Cui, Li-li Yang, Ning Zhang, Li-juan Zhao   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The repeatability and validity of questionnaires assessing occupational physical activity – a systematic review

Scandinavian Journal of Work, Environment & Health, 2011
OBJECTIVES: This study aims to review systematically the repeatability and validity of questionnaires used to assess occupational physical activity among healthy adults. METHODS: We searched PubMed and Embase using occupational, work-related, job-related,
Lydia Kwak, Karin I Proper, Maria Hagströmer, Mattias Sjöström   +3 more
doaj   +1 more source

Chip Quality as a Function of Harvesting Methodology

Chemical Engineering Transactions, 2017
The study aimed to evaluate the aboveground dry biomass production and the quality of fresh and dried chips obtained by eight different species grown under SRC culture and subjected to two harvesting systems and chipping devices. The present study was part of a long project including different species and management regime of a SRC plantation, which ...
FAUGNO, SALVATORE, Civitarese, Vincenzo, Assirelli, Alberto, Sperandio, Giulio, SAULINO, LUIGI, CRIMALDI, MARIANO, SANNINO, MAURA   +6 more
openaire   +3 more sources