Results 111 to 120 of about 578,219 (312)

Real‐world evaluation of interconsensus agreement of risk of bias tools: A case study using risk of bias in nonrandomized studies‐of interventions (ROBINS‐I)

Cochrane Evidence Synthesis and Methods
Background Risk of bias (RoB) tools are critical in systematic reviews and affect subsequent decision‐making. RoB tools should have adequate interrater reliability and interconsensus agreement.
Samer Saadi, Bashar Hasan, Adel Kanaan, Mohamed Abusalih, Zin Tarakji, Mustafa Sadek, Ayla Shamsi Basha, Mohammed Firwana, Zhen Wang, M. Hassan Murad   +9 more
doaj   +1 more source

The repeatability and validity of questionnaires assessing occupational physical activity – a systematic review

Scandinavian Journal of Work, Environment & Health, 2011
OBJECTIVES: This study aims to review systematically the repeatability and validity of questionnaires used to assess occupational physical activity among healthy adults. METHODS: We searched PubMed and Embase using occupational, work-related, job-related,
Lydia Kwak, Karin I Proper, Maria Hagströmer, Mattias Sjöström   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Methodological quality assessment of individual studies.

, 2023
Methodological quality assessment of individual studies.
Alejandra Aguilar-Latorre (6556079), Bárbara Oliván-Blázquez (539766), Rosa Magallón-Botaya (4967800), Emmanouil K. Symvoulakis (9771763), Iván Cavero-Redondo (2635543), Christos Lionis (54187), Celia Álvarez-Bueno (2635540), Ángela Asensio-Martínez (4967815)   +7 more
core   +1 more source

Methodological improvements are needed in network meta analyses of antidiabetic drugs for type 2 diabetes mellitus

Frontiers in Endocrinology
IntroductionNumerous network meta-analyses have compared the efficacy of antidiabetic drugs for type 2 diabetes mellitus. However, a systematic assessment of their methodological and reporting quality remains lacking.MethodsWe searched the PubMed, Embase,
Anna Dai, Anna Dai, Yang Liu, Yang Liu, Jiali Yin, Jiali Yin, Qianqian Wang, Qianqian Wang, Maoyi Yang, Xiaoli Ji, Zhipeng Hu   +10 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Scale for methodological quality assessment.

, 2013
Scale for methodological quality assessment.
Yan Deng (159032), Cui-Ju Mo (448787), Xue Qin (123365), Xiu-Li Huang (448786), Zhi-Yu Zeng (448784), Qi-Liu Peng (448785), Jin-Min Zhao (448788), Shan Li (110392)   +7 more
core   +1 more source

Methodology for Assessment of Linked Data Quality. [PDF]

, 2014
With the expansion in the amount of data being produced as Linked Data (LD), the opportunity to build use cases has also increased. However, a crippling problem to the reliability of these use cases is the underlying poor data quality. Moreover, the ability to assess the quality of the consumed LD, based on the satisfaction of the consumers' quality ...
Rula, A, Zaveri, A
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source