Results 191 to 200 of about 271,187 (352)

Effect of vepdegestrant, a PROTAC oestrogen receptor degrader, on dabigatran and rosuvastatin pharmacokinetics in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effects of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) oestrogen receptor degrader, on the pharmacokinetics of dabigatran (a P‐glycoprotein [P‐gp] substrate) and rosuvastatin (a breast cancer resistance protein [BCRP] substrate).
Derek Z. Yang, Li Zhou, Jennifer A. Winton, Kyle T. Matschke, Constantino Kantaridis, Kristine Doyle, Kimberly C. Lee, Naihan Chen, Yuanyuan Zhang, Weiwei Tan   +9 more
wiley   +1 more source

Hormonal and electrolyte predictors for methotrexate versus surgery in ectopic pregnancy. [PDF]

PLoS One
Başkıran Y, Uçkan K, Çeleğen İ, Tanoğlu FB.   +3 more
europepmc   +1 more source

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

, 1976
Rodney E. Kellems, F W Alt, Robert Schimke   +2 more
openalex   +1 more source

Reply

Arthritis &Rheumatology, EarlyView.
Spencer I. Danto, Elena Peeva
wiley   +1 more source

The Effect of α‐Mangostin on the Pharmacokinetic Profile of Tofacitinib in Rats Both In Vitro and In Vivo

Biopharmaceutics &Drug Disposition, EarlyView.
α‐mangostin (α‐MG) significantly affected tofacitinib metabolism by competing for the same site in CYP3A4. Co‐administration of these two medicines poses a potential herb–drug interaction. ABSTRACT This study investigated the effects of α‐mangostin (α‐MG) on the pharmacokinetics of tofacitinib in vitro and in vivo, aiming to recommend its appropriate ...
Jiange Yao, Zebei Lu, Quan Zhou, Abdullah Al Mamun, Yaru Shi, Shuanghu Wang, Ying Yao   +6 more
wiley   +1 more source

A case report of cutaneous Langerhans cell Histiocytosis in an infant: a therapeutic challenge. [PDF]

Oxf Med Case Reports
Khanje L, Khanje K, Alqato S.
europepmc   +1 more source

Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells.

, 1976
Daniel Bogenhagen, David A. Clayton
openalex   +1 more source

SYNTHESIS OF METHOTREXATE POLYGLUTAMATES IN CULTURED HUMAN CELLS [PDF]

, 1977
David S. Rosenblatt, V H Whitehead, Matthias Dupont, MJ Vuchich, N Vera, C. R. Scriver   +5 more
openalex   +1 more source

Contribution of Organic Anion Transporter 3 in Delayed Elimination of Methotrexate by Concomitant Administration of Febuxostat

Biopharmaceutics &Drug Disposition, EarlyView.
Coadministration of the xanthine oxidase inhibitor, febuxostat, delayed elimination of methotrexate, at least in part, by noncompetitive inhibition of human organic anion transporter 3‐mediated methotrexate transport at clinical concentrations. The findings of this study provide novel information on drug interactions associated with febuxostat ...
Kenji Ikemura, Sakura Kobayashi, Danni Wang, Masahiro Okuda   +3 more
wiley   +1 more source

Two Consecutive Days of Low-Dose Methotrexate Toxicity: A Diagnostic Challenge. [PDF]

Cureus
Harimohan H, Huynh Q, Yasonova M, Moosavi L, Khamlong M, Garcia Pacheco I.   +5 more
europepmc   +1 more source