Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs [PDF]
, 1993 Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506.
Cramer, D +6 more
core +1 more source
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
, 2016 Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
Long-term renal function and hypertension in adult survivors of childhood sarcoma [PDF]
, 2018 Aim: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for ...
Andreoli, Gianmarco +6 more
core +1 more source
Biologics May Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High-Risk Lesions. [PDF]
, 2020 ObjectiveTo evaluate whether biologic disease-modifying antirheumatic drugs (DMARDs) decrease cardiovascular disease (CVD) risk in rheumatoid arthritis (RA) and whether biologic DMARDs might have a beneficial effect on coronary plaque formation or ...
Budoff, Matthew J +3 more
core +1 more source
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
Leukemia, 2020 Folate metabolism enables cell growth by providing one-carbon (1C) units for nucleotide biosynthesis. The 1C units are carried by tetrahydrofolate, whose production by the enzyme dihydrofolate reductase is targeted by the important anticancer drug ...
J. García-Cañaveras +10 more
semanticscholar +1 more source
Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice
Frontiers in Molecular Neuroscience, 2013 We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies.
Andre Michael Mueller +7 more
doaj +1 more source
Journal of Pharmacological Sciences, 2020 The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as
Saki Shiga +5 more
doaj +1 more source
Disease activity and cognition in rheumatoid arthritis : an open label pilot study [PDF]
, 2012 Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories.
Birchall, Daniel +6 more
core +1 more source
Methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis
Pediatric Rheumatology Online Journal, 2017 Background Methotrexate is the most commonly used disease modifying antirheumatic drug in the treatment of juvenile idiopathic arthritis and can be effective in controlling disease in many patients.
Sonja Falvey +3 more
doaj +1 more source
Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy [PDF]
, 2008 Molluscum contagiosum is a common viral skin infection in children with atopic diathesis and not rare in HIV patients. We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.
Alexander Vasilevic Kuznetsov +7 more
core +1 more source