Results 51 to 60 of about 154,899 (297)

A necroptosis‐related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma

Cancer Medicine, Volume 11, Issue 24, Page 5079-5096, December 2022., 2022
Necroptosis is a newly discovered form of cell necrosis that plays a vital role in cancer development. We identified a necroptosis‐related gene signature based on the TCGA cohort, which was validated externally in the ICGC‐LIRI‐JP and GSE14520 cohorts.
Junliang Chen, Huaitao Wang, Lei Zhou, Zhihao Liu, Hui Chen, Xiaodong Tan   +5 more
wiley   +1 more source

Management of Caesarean scar pregnancy with or without methotrexate before curettage: human chorionic gonadotropin trends and patient outcomes

BMC Pregnancy and Childbirth, 2018
Background To evaluate the effects of systemic methotrexate in cesarean scar pregnancy (CSP) patients treated with ultrasound-guided suction curettage. Methods A retrospective review of all women presenting with CSP treated with ultrasound-guided suction
Sheng Wang, Rajluxmee Beejadhursing, Xiangyi Ma, Ya Li   +3 more
doaj   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up

Cancer Medicine, Volume 11, Issue 24, Page 4743-4755, December 2022., 2022
This paper provides an overview of the extramedullary plasmacytoma cases reported between 1999 and 2021. The global patients’ cohort and the current therapy options are compared to our previous report from 1999. Abstract Background Extramedullary plasmacytoma (EMP) is a solitary tumor consisting of neoplastic plasma cells, with very little to no bone ...
Adrian Holler, Iwona Cicha, Markus Eckstein, Marlen Haderlein, Marina Pöttler, Anja Rappl, Heinrich Iro, Christoph Alexiou   +7 more
wiley   +1 more source

National trends in treatments for ectopic pregnancy in Japan from 2010 to 2020: a retrospective observational study

Journal of Obstetrics and Gynaecology
Background Ectopic pregnancy (EP) can be treated surgically or nonsurgically. In many countries, methotrexate is frequently used as a first-line medical treatment, and its effect is similar to that of surgery in selected patients. We aimed to investigate
Risa Ishida, Hiroyuki Ohbe, Gentaro Izumi, Daisuke Shigemi, Hiroki Matsui, Kaori Koga, Hideo Yasunaga, Yutaka Osuga   +7 more
doaj   +1 more source

Synthesis of Methotrexate loaded Cerium fluoride nanoparticles with pH sensitive extended release coupled with Hyaluronic acid receptor with plausible theranostic capabilities for preclinical safety studies [PDF]

arXiv, 2016
A key challenge in drug delivery systems is the real time monitoring of delivered drug and subsequent response. Recent advancement in nanotechnology has enabled the design and preclinical implementation of novel drug delivery systems (DDS) with theranostic abilities.
arxiv  

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

Phase 2 results of lisocabtagene maraleucel in Japanese patients with relapsed/refractory aggressive B‐cell non‐Hodgkin lymphoma

Cancer Medicine, Volume 11, Issue 24, Page 4889-4899, December 2022., 2022
This analysis assessed safety and efficacy of lisocabtagene maraleucel (liso‐cel), an autologous CD‐19‐directed CAR T‐cell product, in Japanese patients with R/R aggressive LBCL in Cohort 3 of TRANSCEND WORLD (NCT03484702). Liso‐cel demonstrated meaningful efficacy and a manageable safety profile in Japanese patients with R/R LBCL.
Shinichi Makita, Go Yamamoto, Dai Maruyama, Yuki Asano‐Mori, Daisuke Kaji, Revathi Ananthakrishnan, Ken Ogasawara, Lara Stepan, Claudia Schusterbauer, Nils Rettby, Jens Hasskarl, Koji Izutsu   +11 more
wiley   +1 more source

Assessing usability, label comprehension, pen robustness and pharmacokinetics of a self-administered prefilled autoinjector pen of methotrexate in patients with rheumatoid arthritis

SAGE Open Medicine, 2014
Objective: To assess usability, bioavailability, and safety of subcutaneous self-administration of 0.3 mL of methotrexate 50 mg/mL solution via a prefilled autoinjector pen (methotrexate pen) in patients with rheumatoid arthritis.
Jaime A Pachon, Alan J Kivitz, Kay-Uwe Heuer, Uwe Pichlmeier   +3 more
doaj   +1 more source

Evaluation of the efficacy and safety of combined treatment with methotrexate and a broadband medium-wave phototherapy for psoriasis patients

Vestnik Dermatologii i Venerologii, 2017
Goal. To evaluate the efficacy and safety of combined treatment with methotrexate and a broadband medium-wave phototherapy for psoriasis patients. Materials and methods. As many as 365 psoriasis patients underwent examination and treatment.
D. V. Grigoriyev, V. V. Vladimirov
doaj   +1 more source