Results 41 to 50 of about 1,050,423 (388)
Research Progress on Epigenetics of Diabetic Cardiomyopathy in Type 2 Diabetes
Frontiers in Cell and Developmental Biology, 2021 Diabetic cardiomyopathy (DCM) is characterized by diastolic relaxation abnormalities in its initial stages and by clinical heart failure (HF) without dyslipidemia, hypertension, and coronary artery disease in its last stages.
Jianxin Deng +4 more
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Uniformity of Peptide Release Is Maintained by Methylation of Release Factors
Cell Reports, 2016 Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif.
William E. Pierson +5 more
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DNA methylation GrimAge strongly predicts lifespan and healthspan
Aging, 2019 It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan.
A. Lu +13 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2019 Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. IDH exists in three different isoforms, whose mutation can cause many solid tumors, especially gliomas in ...
XiaoYong Pan +11 more
doaj +1 more source
SETD3 is an actin histidine methyltransferase that prevents primary dystocia. [PDF]
, 2019 For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur1. Despite the pervasiveness of His73 methylation, which we find is conserved in several model animals and plants, its function remains unclear and the ...
Carette, Jan E +21 more
core +1 more source
ChemInform Abstract: Alkyl Methyl Carbonates as Methylating Agents. The O‐Methylation of Phenols. [PDF]
ChemInform, 2000 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PEROSA, Alvise +3 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 This study aimed to investigate the role of methylation of MALAT1 and miR-146a in the pathogenesis of chronic obstructive pulmonary disease (COPD). COPD patients were grouped according to their methylation status of MALAT1 and miR-146a promoters, and we ...
Li Sun +9 more
doaj +1 more source
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]
, 2018 DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola +3 more
core +1 more source
DNA methylation patterns and epigenetic memory.
Genes & Development, 2002 The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional ...
A. Bird
semanticscholar +1 more source
DNA methylation and DNA methyltransferases [PDF]
, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
core +3 more sources