Results 41 to 50 of about 881,260 (340)

Global Methylation and Protamine Deficiency in Ram Spermatozoa Correlate with Sperm Production and Quality but Are Not Influenced by Melatonin or Season

Animals, 2020
This study assessed whether the seasonal effects of melatonin that upregulate ram reproductive function alter sperm global methylation or protamine deficiency and whether these parameters corresponded to ram endocrinology, semen production and quality ...
Kelsey R. Pool, Jessica P. Rickard, Simon P. de Graaf   +2 more
doaj   +1 more source

Omics-informed CNV calls reduce false-positive rates and improve power for CNV-trait associations

HGG Advances, 2022
Summary: Copy-number variations (CNV) are believed to play an important role in a wide range of complex traits, but discovering such associations remains challenging.
Maarja Lepamets, Chiara Auwerx, Margit Nõukas, Annique Claringbould, Eleonora Porcu, Mart Kals, Tuuli Jürgenson, Andrew Paul Morris, Urmo Võsa, Murielle Bochud, Silvia Stringhini, Cisca Wijmenga, Lude Franke, Hedi Peterson, Jaak Vilo, Kaido Lepik, Reedik Mägi, Zoltán Kutalik   +17 more
doaj   +1 more source

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]

, 2018
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh, Baccarelli, Andrea A, Cardenas, Andres, Coull, Brent A, de Kluizenaar, Yvonne, DeMeo, Dawn L, den Dekker, Martijn, Duijts, Liesbeth, Felix, Janine F, Gibson, Heike, Gilman, Matthew W, Gold, Diane R, Harris, Maria H, Hivert, Marie-France, Jaddoe, Vincent W, Litonjua, Augusto A, Oken, Emily, Peng, Cheng, Rifas-Shiman, Sheryl L, Sagiv, Sharon K, Schwartz, Joel   +20 more
core   +1 more source

Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma

Gut and Liver, 2008
Background/Aims: RUNX3 (PEBP2ՁC/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association between RUNX3 methylation and the ...
doaj   +1 more source

Aberrant DNA methylation of PTPRG as one possible mechanism of its under‐expression in CML patients in the State of Qatar

Molecular Genetics & Genomic Medicine, 2020
Background Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated in chronic myeloid ...
Mohamed A. Ismail, Muthanna Samara, Ali Al Sayab, Mohamed Alsharshani, Mohamed A. Yassin, Govindarajulu Varadharaj, Marzia Vezzalini, Luisa Tomasello, Maria Monne, Hisham Morsi, M. Walid Qoronfleh, Hatem Zayed, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al‐Dewik   +15 more
doaj   +1 more source

Changes in Higher-Order Chromosomal Structure of Klebsiella pneumoniae Under Simulated Microgravity

Frontiers in Microbiology, 2022
Our previous work have shown that certain subpopulations of Klebsiella pneumoniae exhibit significant phenotypic changes under simulated microgravity (SMG), including enhanced biofilm formation and cellulose synthesis, which may be evoked by changes in ...
Yahao Wang, Wenlong Shen, Man Yin, Wenhua Huang, Bingyu Ye, Ping Li, Shu Shi, Ge Bai, Xinjie Guo, Yifei Jin, Kailin Lin, Yan Zhang, Yongqiang Jiang, Junfeng Wang, Yanping Han, Zhihu Zhao   +15 more
doaj   +1 more source

Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]

, 2019
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep, García Pastor, Lucía, Jakomin, Marcello, Puerta Fernández, Elena, Sánchez Romero, María Antonia   +4 more
core   +1 more source

Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation

Current Issues in Molecular Biology
Tissue regeneration therapy based on human dental pulp cells (hDPCs) faces the distinct challenge of cellular senescence during massive expansion in vitro.
Shuhan Zhou, Jingyao Cui, Yu Shi
doaj   +1 more source

Placental DNA Methylation Abnormalities in Prenatal Conotruncal Heart Defects

Frontiers in Genetics, 2022
Objective: This study aims to characterize the abnormal changes in placental DNA methylation associated with conotruncal heart defects (CTDs) and the level of methylation as epigenetic biomarkers for CTDs detection.Methods: This was a prospective study ...
Jingjing Liu, Jingjing Liu, Yuduo Wu, Yuduo Wu, Hairui Sun, Hairui Sun, Xiaowei Liu, Xiaowei Liu, Xiaoyan Gu, Xiaoyan Gu, Ying Zhao, Ying Zhao, Ye Zhang, Ye Zhang, Jiancheng Han, Jiancheng Han, Yihua He, Yihua He   +17 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell, Adam G. West, AG West, AG West, AG West, Alan Hair, CD Lewis, CL Li, D Macleod, F Antequera, F Recillas-Targa, Gary Felsenfeld, H Gowher, Humaira Gowher, IG Lin, J Aitsebaomo, J Stalder, JA Wallace, Jacqueline Dickson, JH Chung, JH Chung, JP Issa, KS Wendt, L Valenzuela, Lisa Stubbs, M Brandeis, M Gaszner, M Marin, M Oki, MC Barton, Miklos Gaszner, MJ Pikaart, MM Suzuki, MN Prioleau, MN Prioleau, MS Turker, N Koyano-Nakagawa, PA Jones, PB Talbert, PD Jackson, PE Szabo, R Buckle, R Jaenisch, R Kellum, R Straussman, Ruslan Strogantsev, S Fan, S Huang, S Huang, S Yao, SP Clark, T Hashimshony, V Mutskov, VJ Mutskov, VK Rakyan   +54 more
core   +5 more sources