Results 71 to 80 of about 725,318 (280)

Evidence for distinct biological perturbations in PTSD with severe child abuse: implications for PTSD biomarkers

European Journal of Psychotraumatology, 2012
Rationale/statement of the problem : Evidence for distinct biological perturbations in posttraumatic stress disorder (PTSD) with severe child abuse versus no child abuse: consequences for robust biomarkers for PTSD.
Divya Mehta
doaj   +1 more source

Identification of Genes with Altered Methylation and Its Role in Early Diagnosis of Sepsis-Induced Acute Respiratory Distress Syndrome

International Journal of General Medicine, 2021
Jihua Feng,* Jielong Pang,* Dan He,* Zimeng Wu, Qian Li, Pan Ji, Cuiying He, Zhimei Zhong, Hongyuan Li, Jianfeng Zhang Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, People’s Republic
Feng J, Pang J, He D, Wu Z, Li Q, Ji P, He C, Zhong Z, Li H, Zhang J   +9 more
doaj  

Crystallographic and Computational Characterization of Methyl Tetrel Bonding in S-Adenosylmethionine-Dependent Methyltransferases

Molecules, 2018
Tetrel bonds represent a category of non-bonding interaction wherein an electronegative atom donates a lone pair of electrons into the sigma antibonding orbital of an atom in the carbon group of the periodic table.
Raymond C. Trievel, Steve Scheiner
doaj   +1 more source

Identification of Methylation Immune Subtypes and Establishment of a Prognostic Signature for Gliomas Using Immune-Related Genes

Frontiers in Immunology, 2021
DNA methylation patterns are essential in understanding carcinogenesis. However, the relationship between DNA methylation and the immune process has not been clearly established—this study aimed at elucidating the interaction between glioma and DNA ...
Zhengang Hu, Hao Zhang, Fan Fan, Zeyu Wang, Jiahao Xu, Yunying Huang, Ziyu Dai, Hui Cao, Xun Zhang, Zhixiong Liu, Zhixiong Liu, Quan Cheng, Quan Cheng, Quan Cheng   +13 more
doaj   +1 more source

DOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemia

Cancer Medicine, 2019
Background Downstream of tyrosine kinase 6 (DOK6), which is specifically expressed in the nervous system, was previously recognized as an adapter only in neurite outgrowth.
Guo‐Kang Sun, Li‐Juan Tang, Jing‐Dong Zhou, Zi‐Jun Xu, Lan Yang, Qian Yuan, Ji‐Chun Ma, Xing‐Hui Liu, Jiang Lin, Jun Qian, Dong‐Ming Yao   +10 more
doaj   +1 more source

Sulforaphane Suppressed Stemness Characters of Lung Adenocarcinoma Stem Cells by Down-regulating Methylation of miR-200c Promoter

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the effect of sulforaphane (SFN) on the proliferation and self-renewal of lung cancer stem cells and its regulatory mechanism.
LIANG Guangxia, QIN Xituan, XIE Wei, XIE Youke   +3 more
doaj   +1 more source

The Role of Cytosine Methylation on Charge Transport through a DNA Strand [PDF]

J Chem Phys. 2015 Sep 7;143(9):094306, 2017
Cytosine methylation has been found to play a crucial role in various biological processes, including a number of human diseases. The detection of this small modification remains challenging. In this work, we computationally explore the possibility of detecting methylated DNA strands through direct electrical conductance measurements.
arxiv   +1 more source

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research [PDF]

, 2011
Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not include the DNA sequence itself.
A Hellman, A Zemach, AK Maunakea, AP Bird, C Tufarelli, D Aran, D Takai, D Zilberman, E Hodges, E Segal, EN Gal-Yam, H Cedar, H Han, HH Ng, J M Flanagan, JA Yoder, JD Lieb, JF Smith, JK Choi, JK Choi, JM Flanagan, JM Flanagan, JT Huff, K Appleton, K Flower, KR Blahnik, L Nanty, L Wild, M Lorincz, M Weber, MA Hahn, MA Hahn, MG Guenther, MJ Carrozza, MM Suzuki, MP Ball, N Shenker, PA Jones, R Appanah, RD Hawkins, S Feng, S Fu, TA Rauch, TE Fandy, V Rishi, VM Komashko, VM Komashko, WA Schulz, X Zhang, Y Li, YJ Shann   +50 more
core   +1 more source

Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers

Neoplasia: An International Journal for Oncology Research, 2005
The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert, Suzanne H. Mooney, Lori Tonnes-Priddy, Joe Lograsso, Juliane Hoffmann, Jie Chent, Christoph Rocken, Hans-Ulrich Schulz, Peter Malfertheiner, Catherine Lofton-Day   +9 more
doaj   +1 more source

UV photodissociation of methyl bromide and methyl bromide cation studied by velocity map imaging [PDF]

Journal of Chemical Physics 130 (2009) 034304, 2009
We employ the velocity map imaging technique to measure kinetic energy and angular distributions of state selected CH3 (v2=0,1,2,3) and Br (2P3/2,2P1/2) photofragments produced by methyl bromide photolysis at 215.9 nm. These results show unambiguously that the Br and Br* forming channels result in different vibrational excitation of the umbrella mode ...
arxiv   +1 more source