Results 71 to 80 of about 1,069,555 (390)
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the effect of sulforaphane (SFN) on the proliferation and self-renewal of lung cancer stem cells and its regulatory mechanism.
LIANG Guangxia +3 more
doaj +1 more source
Nature Communications, 2018 Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent cell death events in the body. Here, we present an approach for unbiased determination of the tissue origins of cfDNA, using a reference methylation atlas of ...
J. Moss +22 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Methylation status of Vitamin D receptor gene promoter in benign and malignant adrenal tumors [PDF]
, 2015 We previously showed a decreased expression of vitamin D receptor (VDR) mRNA/protein in a small group of adrenocortical carcinoma (ACC) tissues, suggesting the loss of a protective role of VDR against malignant cell growth in this cancer type ...
Cappellesso, Rocco +7 more
core +4 more sources
Shedding light upon the complex net of genome size, genome composition and environment in chordates
The European Zoological Journal, 2020 The nucleotype theory has been advanced on the basis of studies regarding genome size and composition in various plant and animal species, i.e. the influence that genome can have on the phenotype independently of the informational content of DNA.
A. Canapa +5 more
doaj +1 more source
Frontiers in Immunology, 2021 DNA methylation patterns are essential in understanding carcinogenesis. However, the relationship between DNA methylation and the immune process has not been clearly established—this study aimed at elucidating the interaction between glioma and DNA ...
Zhengang Hu +13 more
doaj +1 more source
Magic methylation with methyl-containing peroxides
Chemical ScienceMethyl groups are abundant in pharmaceuticals, and their installation has garnered significant attention. This review summarises advancements in the use of methyl-containing peroxides as reagents for a variety of methylation reactions.
Daliah Farajat, Yuhua Zhang, Chao-Jun Li
openaire +2 more sources
EcoSal Plus, 2009 The DNA of Escherichia coli contains 19,120 6-methyladenines and 12,045 5-methylcytosines in addition to the four regular bases, and these are formed by the postreplicative action of three DNA methyltransferases. The majority of the methylated bases are formed by the Dam and Dcmmethyltransferases encoded by the
Marinus, Martin G. +1 more
openaire +4 more sources
The role of m6A RNA methylation in human cancer
Molecular Cancer, 2019 N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs).
Xiaoyu Chen, Jing Zhang, Jinshui Zhu
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source