Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms [PDF]
Genes and Environment, 2023 Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020, 2021, and 2022) was tested for three ...
Yasushi Yamazoe +3 more
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Osteotoxicity of 3-methylcholanthrene in fish [PDF]
Ecotoxicology and Environmental Safety, 2018 Many chemicals produced by human activities end up in the aquatic ecosystem causing adverse developmental and reproductive effects in aquatic organisms. There is evidence that some anthropogenic chemicals disturb bone formation and skeletal development but the lack of suitable in vitro and in vivo systems for testing has hindered the identification of ...
Vincent Laizé +2 more
exaly +3 more sources
Inhibition activity of Artemisia vulgaris L. on Bhas 42 cell transformation [PDF]
Scientific ReportsSeveral factors can contribute to cancer development. Various methods are in use for cancer treatment, although their complications can be a cause of concern. Artemisia vulgaris L.
Paweena Pitimontol +8 more
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Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and ß-ionone in rat tissues [PDF]
Brazilian Journal of Medical and Biological Research, 2003 Cytochrome P450 (CYP) 2A enzymes are involved in the metabolism of numerous drugs and hormones and activate different carcinogens. Human CYP2A6, mouse CYP2A5 and rat CYP2A3 are orthologous enzymes that present high similarity in their amino acid sequence
A.B. Robottom-Ferreira +4 more
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Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin [PDF]
Toxicology Reports, 2023 Diazinon (DZN) is an insecticide extensively used to control pests in crops and animals. However, its indicriminated use may lead to liver damage in animals and humans. This study aimed to evaluate the toxicity of DZN (25–150 µM) on human hepatoblastoma (
Camila Araújo Miranda +9 more
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Identification and editing of stem-like cells in methylcholanthrene-induced sarcomas [PDF]
OncoImmunology, 2019 The cancer stem cell (CSC) paradigm posits that specific cells within a tumor, so-called CSC-like cells, have differing levels of tumorigenicity and chemoresistance.
Emilie T. E. Gross +6 more
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Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.
PLoS ONE, 2015 Reactive oxygen species (ROS) produced by the inducible NADPH oxidase type 2 (NOX2) complex are essential for clearing certain infectious organisms but may also have a role in regulating inflammation and immune response.
Maarten A Ligtenberg +4 more
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Investigating the Use of Diagnostic Genes in Integrated Monitoring with a Laboratory and Field Study on Flounder (Platichthys flesus) [PDF]
ToxicsFor many years, there has been increasing concern about the effects of the presence of hazardous substances in the environment. The chemical and biological effect (BE) monitoring of these pollutants has proven difficult due to low environmental ...
Michelle C. Giltrap +8 more
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Exploring the association between air pollutants and non-small cell lung cancer using network toxicology and machine learning [PDF]
Discover OncologyBackground Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. The urgent need to understand its risk factors and develop effective treatment strategies drives ongoing research in this field.
Qiang Zhao, Zhiqiang Zhao, Kunpeng Du
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Characterization of a novel cell line established from mice gastrointestinal stromal model by chemical induction [PDF]
Translational OncologyBackground: Gastrointestinal stromal tumors (GISTs) are a type of tumor that originates from gastrointestinal mesenchymal tissue. Although several somatic or germline mutation GIST mice were established, however, there is still a lack of an authentic ...
Zhan Zhao +17 more
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