Some Physiological Effects of Non-Gaseous Exhaust Material from an Internal Combustion Engine [PDF]
, 1966 Author Institution: Department of Chemistry, Ashland College, Ashland, OhioExhaust materials were collected from a four-cylinder automobile engine that consumed 1 quart of lubricating oil for each 5 gal of gasoline.
Scholl, Allen W.
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Mutations in Escherichia Coli Induced by Chemical Agents [PDF]
, 1947 For over two decades geneticists have been interested in the possibility of inducing mutations with chemicals. Particularly, it has been hoped that mutagenic compounds might be discovered which, through their specificity of action, would lead to some ...
Witkin, E. M.
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MODIFICATION OF REPRODUCTIVE FUNCTION IN THE RAT BY 3-METHYLCHOLANTHRENE
Pharmacological Research, 1997 Repeated exposure of adult female Wistar rats to 3-methylcholanthrene (MC) (25 mg kg(-1) b.w., i.p., 2xwk, 1 mo) was associated with a significant increase in estrus cycle length. In addition, an increased frequency of females with constant diestrus and abnormal cycles was observed.
Konstandi, M. +5 more
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Biology Open, 2019 Recently, several promising treatments for high-grade gliomas (HGGs) failed to provide significant benefit when translated from the preclinical setting to patients. Improving the animal models is fundamental to overcoming this translational gap.
Matteo Riva +11 more
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Genomic rearrangements in mouse C3H/10T1/2 cells transformed by X-rays, UV-C, and 3-methylcholanthrene, detected by a DNA fingerprint assay[superscript 1] [PDF]
, 1992 Genomic rearrangements occurring in C3H/10T1/2 cells transformed by X-rays were examined with a DNA fingerprint assay. Four multilocus and multiallele probes were employed (M, X, H10, and H16) that detect different families of minisatellite sequences ...
Paquette, Benoit
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Journal of Pharmacy & Pharmaceutical Sciences, 2010 Purpose. This study was performed to find which types of hepatic CYP isoforms are responsible for the metabolism of mirodenafil (a new erectogenic) and one of its metabolite, SK3541, using various hepatic CYP inducers and inhibitors in rats.
Young Hee Choi +4 more
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Natural killer (NK) cells and their involvement in different types of cancer. Current status of clinical research [PDF]
, 2017 Natural killer cells are the main agents of innate immunity. Since 1970, various studies have repeatedly confirmed their involvement in decreasing local tumor growth and also decreasing the risk of metastasis, due to their cytotoxic effects and also ...
Moldovan, Adina D. +2 more
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Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine [PDF]
, 2001 Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the synthesis of S-adenosylmethionine (AdoMet), the most important biological methyl donor. Liver MAT I/III is the product of the MAT1A gene.
Avila, M.A. (Matías Antonio) +6 more
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Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons [PDF]
, 2006 This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a ...
Iwano, Shunsuke +3 more
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Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene [PDF]
, 2009 Cytochrome P4501A1 (CYP1A1), an enzyme known to metabolize polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR). The involvement of protein kinase C (PKC) in the regulation of AhR signal transduction pathway, has been ...
Bassi, A. +21 more
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