Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms [PDF]
Genes and Environment, 2023 Understanding of metabolic processes is a key factor to evaluate biological effects of carcinogen and mutagens. Applicability of fused-grid Template* systems of CYP enzymes (Drug Metab Pharmacokinet 2019, 2020, 2021, and 2022) was tested for three ...
Yasushi Yamazoe +3 more
doaj +2 more sources
Inhibition activity of Artemisia vulgaris L. on Bhas 42 cell transformation [PDF]
Scientific ReportsSeveral factors can contribute to cancer development. Various methods are in use for cancer treatment, although their complications can be a cause of concern. Artemisia vulgaris L.
Paweena Pitimontol +8 more
doaj +2 more sources
Exploring Paediatric Jaw Osteosarcoma: A Detailed Case Report of a 12‐Year‐Old Girl and Review of the Literature [PDF]
Case Reports in Dentistry, Volume 2025, Issue 1, 2025.Osteosarcoma, the most common primary bone malignancy, rarely affects the jaw, representing only 6%–10% of cases. Jaw osteosarcoma typically occurs in individuals between the ages of 30 and 50 years and is uncommon in children. It often involves the mandible, especially in males, presenting with swelling, tooth mobility, and paraesthesia rather than ...
Jessica Simpson +3 more
wiley +2 more sources
Investigating the Use of Diagnostic Genes in Integrated Monitoring with a Laboratory and Field Study on Flounder (Platichthys flesus) [PDF]
ToxicsFor many years, there has been increasing concern about the effects of the presence of hazardous substances in the environment. The chemical and biological effect (BE) monitoring of these pollutants has proven difficult due to low environmental ...
Michelle C. Giltrap +8 more
doaj +2 more sources
Role of biotransformation in the diazinon-induced toxicity in HepG2 cells and antioxidant protection by tetrahydrocurcumin [PDF]
Toxicology Reports, 2023 Diazinon (DZN) is an insecticide extensively used to control pests in crops and animals. However, its indicriminated use may lead to liver damage in animals and humans. This study aimed to evaluate the toxicity of DZN (25–150 µM) on human hepatoblastoma (
Camila Araújo Miranda +9 more
doaj +2 more sources
Characterization of a novel cell line established from mice gastrointestinal stromal model by chemical induction [PDF]
Translational OncologyBackground: Gastrointestinal stromal tumors (GISTs) are a type of tumor that originates from gastrointestinal mesenchymal tissue. Although several somatic or germline mutation GIST mice were established, however, there is still a lack of an authentic ...
Zhan Zhao +17 more
doaj +2 more sources
Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing [PDF]
Particle and Fibre ToxicologyBackground Inhalation of respirable crystalline silica particles, including quartz, is associated with an increased risk of developing pathologies, including persistent lung inflammation, fibrosis, cancer, and systemic autoimmunity.
Cristina Pavan +8 more
doaj +2 more sources
Effects of cysteamine on 3-methylcholanthrene - induced fibrosarcoma in mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013 Understanding the biology, developing methods for prevention and treatment of tumors is of great importance. The present study was investigated protective effects of the cysteamine on 3-methylcholantrene-induced fibrosarcoma in mice.
DOGAN A +5 more
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Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. [PDF]
PLoS ONE, 2014 Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has suggested
Yoko Nagumo +6 more
doaj +1 more source
The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]
PLoS ONE, 2011 Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo +7 more
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