3-Methylcholanthrene, an AhR Agonist, Caused Cell-Cycle Arrest by Histone Deacetylation through a RhoA-Dependent Recruitment of HDAC1 and pRb2 to E2F1 Complex [PDF]
PLoS ONE, 2014 We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase ...
Yi-Hsuan Lee, Shu-Hui Juan
exaly +2 more sources
Correction: Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts [PDF]
Cancer Cell International, 2010 Ni Hong +4 more
doaj +2 more sources
Inhibitory Effects of 3-Methylcholanthrene Exposure on Porcine Oocyte Maturation. [PDF]
Int J Mol Sci, 2023 Zhang M +11 more
europepmc +2 more sources
Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes. [PDF]
MedComm (2020)Significance: Immune‐controlled dormant metastases exhibit a unique phenotype, primarily promoted by the Ch25h gene, that can be exploited to discover new biomarkers, as well as the development of therapies to eradicate dormant metastases or control overt metastases.
Chamorro V +10 more
europepmc +2 more sources
Effects of cysteamine on 3-methylcholanthrene - induced fibrosarcoma in mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2013 Understanding the biology, developing methods for prevention and treatment of tumors is of great importance. The present study was investigated protective effects of the cysteamine on 3-methylcholantrene-induced fibrosarcoma in mice.
DOGAN A +5 more
doaj +1 more source
Real-Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis. [PDF]
Adv Sci (Weinh)Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Luo B +16 more
europepmc +2 more sources
Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. [PDF]
PLoS ONE, 2014 Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has suggested
Yoko Nagumo +6 more
doaj +1 more source
The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]
PLoS ONE, 2011 Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo +7 more
doaj +1 more source
The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function
Current Research in Toxicology, 2022 Polycyclic aromatic compounds (PACs) are a broad class of contaminants ubiquitously present in the environment due to natural and anthropogenic activities. With increasing industrialization and reliance on petroleum worldwide, PACs are increasingly being
Genevieve A Perono +3 more
doaj +1 more source
A method for measurement of nanogram quantities of 3-methylcholanthrene in stool samples.
Journal of Lipid Research, 1984 The carcinogen 3-methylcholanthrene can be produced from deoxycholic acid and is postulated by some investigators to play a role in the pathogenesis of colon carcinoma. The small quantities of this compound which could be carcinogenic have been difficult
W C Duane +3 more
doaj +1 more source