Results 21 to 30 of about 25,402 (289)
Brazilian Journal of Medical and Biological Research, 2003 Cytochrome P450 (CYP) 2A enzymes are involved in the metabolism of numerous drugs and hormones and activate different carcinogens. Human CYP2A6, mouse CYP2A5 and rat CYP2A3 are orthologous enzymes that present high similarity in their amino acid sequence
A.B. Robottom-Ferreira +4 more
doaj +1 more source
NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.
International Immunology, 2001 NK1.1(+) V(alpha)14J(alpha)281(+) (NKT) cells can be induced by IL-12 therapy to mediate tumor rejection; however, methylcholanthrene (MCA)-induced fibrosarcoma is the only tumor model described where NKT cells play a natural role in controlling tumor ...
M. Smyth
semanticscholar +2 more sources
JCSM Rapid Communications, Volume 6, Issue 2, Page 122-133, July/December 2023., 2023 Abstract Background Inflammation is a hallmark of cachexia; however, effective anti‐inflammatory treatments have not yet been identified. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a key signalling node linking interleukin‐1 receptor (IL‐1R) and toll‐like receptor (TLR) activation to the production of multiple proinflammatory cytokines that ...
Shuxi Qiao +9 more
wiley +1 more source
Improvement of antitumor therapies based on vaccines and immune-checkpoint inhibitors by counteracting tumor-immunostimulationw [PDF]
, 2018 Immune-checkpoint inhibitors and antitumor vaccines may produce both tumor-inhibitory and tumor-stimulatory effects on growing tumors depending on the stage of tumor growth at which treatment is initiated.
Bustuoabad, Oscar David +8 more
core +2 more sources
BioMed Research International, 2015 The effect of crocetin (C20H24O4) on methylcholanthrene- (MCA-) induced uterine cervical cancer in mice was studied in this paper. After the mice were treated orally with crocetin, maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1β ...
Bing Chen +3 more
semanticscholar +1 more source
A perspective on the impact of radiation therapy on the immune rheostat. [PDF]
, 2017 The advent and success of immune checkpoint inhibitors (ICIs) in cancer treatment has broadened the spectrum of tumours that might be considered "immunogenic" and susceptible to immunotherapeutic (IT) intervention. Not all cancer types are sensitive, and
Ganapathy, Ekambaram +5 more
core +1 more source
The Carcinogenic Activity of Methylcholanthrene in Rats [PDF]
The American Journal of Cancer, 1940 Studies of induced Cysticercus sarcoma in rats have demonstrated (1) a direct relationship between the number of parasites in the host's liver and the duration of the latent period. An increase in the number of cysts decreased directly the average time interval before the onset of malignant disease and increased directly the probability of its ...
M. J. Eisen, M. R. Curtis, W. F. Dunning
openaire +2 more sources
Journal of Carcinogenesis, 2011 Background: The anticancer and antioxidant effects of the aqueous extract of Indigofera aspalathoides on 20-methylcholanthrene (20-MCA) induced fibrosarcoma were investigated in male albino rats.
SSelva Kumar +3 more
semanticscholar +1 more source
Enhancement of experimental metastasis by tumor necrosis factor [PDF]
, 1993 The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model.
Echtenacher, Bernd +5 more
core +2 more sources
Methylcholanthrene-Induced Sarcomas Develop Independently from NOX2-Derived ROS.
PLoS ONE, 2015 Reactive oxygen species (ROS) produced by the inducible NADPH oxidase type 2 (NOX2) complex are essential for clearing certain infectious organisms but may also have a role in regulating inflammation and immune response.
Maarten A Ligtenberg +4 more
doaj +1 more source