Enhancement of Bio-Protective Functions by Low Dose/Dose-Rate Radiation
Dose-Response, 2006 Effects of low-dose-rate gamma-irradiation on the process of tumorigenesis were investigated in mice treated with a carcinogenic agent or irradiated with high dose X-rays at a high dose rate.
Kazuo Sakai +2 more
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Aristolochic Acid Affects Upper Tract Urothelial Cancer Behavior through the MAPK Pathway
Molecules, 2019 The prevalence of upper tract urothelial carcinoma (UTUC) in Taiwan is relatively higher than thatin Western countries. Aristolochic acid (AA), which is widely used in traditional Chinese herbology, is now recognized to be one of the carcinogens for UTUC.
I-Hsuan Chen +8 more
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3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex. [PDF]
PLoS ONE, 2014 We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase ...
Chih-Cheng Chang +4 more
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In vitro studies on the inhibitory effect of lymphoid cells. II. Antitumor activity of lymphoid cells from spontaneous mammary tumor-bearing mice on the autochthonous primary culture tumor cells [PDF]
, 1971 As a step in the elucidation of human cancer immunity we studied antitumor activity of lymphoid cells by conducting a series of cultures using the primary culture of cells from spontaneous mammary cancers from C3H and RIll mice mixed with autochthonous ...
Ohsugi, Masaki
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Acceleration of the development of leukemia and induction of tumors in AKR mice by neo-natal injection of 20-methy-Icholanthrene [PDF]
, 1963 A single subcutaneous injection of 20-methylcholanthrene into newborn AKR mice less than 24 hours old resulted in the acceleration of the development of lymphocytic leukemia, and induction of subcutaneous sarcomas and multiple-lung adenomas ...
Miyoshi, Isao
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OncoImmunology, 2018 Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma.
Vassilis Genoud +7 more
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Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass. [PDF]
PLoS ONE, 2015 Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj +1 more source
Frontiers in Pharmacology, 2022 Acquired cisplatin resistance in cervical cancer therapy is principally caused by reduction in intracellular drug accumulation, which is exerted by hyperactivation of the oncogenic PI3K/Akt signaling axis and overexpression of cisplatin-exporter MRP2 ...
Elizabeth Mahapatra +6 more
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Macrophage migration inhibition-activity after implantation of methylcholanthrene-induced sarcoma, Ehrlich ascites cancer or mouse ascites hepatoma-134 cancer cells in mice [PDF]
, 1976 Cells from methylcholanthrene-induced tumor (MC-tumor), Ehrlich ascites cancer or mouse ascites hepatoma (MH-134) were subcutaneously implanted in dorsal area of mice to examine the specific cell mediated immunity following implantation.
Yumura, Masahito
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In vitro studies on the inhibitory effect of lymph-node cells. I. Antitumor activity of regional lymph-node cells from methylcholanthrene-induced sarcoma bearing mice on the same primary culture sarcoma cells [PDF]
, 1970 As a step in the elucidation of immunity of human cancer from the standpoint of homotransplantation immunity, we conducted mixed cultures of regional lymph node cells from C3H mouse isotransplanted with methylcholanthrene-induced sarcoma (MC-tumor ...
Ohsugi, Masaki
core +1 more source