Results 41 to 50 of about 17,936 (269)

Aryl hydrocarbon receptors in osteoclast lineage cells are a negative regulator of bone mass. [PDF]

PLoS ONE, 2015
Aryl hydrocarbon receptors (AhRs) play a critical role in various pathological and physiological processes. Although recent research has identified AhRs as a key contributor to bone metabolism following studies in systemic AhR knockout (KO) or transgenic
Tai-yong Yu, Wei-jun Pang, Gong-she Yang
doaj   +1 more source

EMAP II Expression Is Increased on Peripheral Blood Cells from Non-Hodgkin Lymphoma

Journal of Immunology Research, 2022
Tumor immune evasion is a lineament of cancer. Endothelial monocyte activating polypeptide-II (EMAP II) has been assumed to impact tumor immune escape significantly.
Manal Mohamed Saber
doaj   +1 more source

Phenethylisothiocyanate Potentiates Platinum Therapy by Reversing Cisplatin Resistance in Cervical Cancer

Frontiers in Pharmacology, 2022
Acquired cisplatin resistance in cervical cancer therapy is principally caused by reduction in intracellular drug accumulation, which is exerted by hyperactivation of the oncogenic PI3K/Akt signaling axis and overexpression of cisplatin-exporter MRP2 ...
Elizabeth Mahapatra, Debomita Sengupta, Ravindra Kumar, Budheswar Dehury, Salini Das, Madhumita Roy, Sutapa Mukherjee   +6 more
doaj   +1 more source

Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. [PDF]

PLoS ONE, 2009
The Forkhead Box m1 (Foxm1) protein is induced in a majority of human non-small cell lung cancers and its expression is associated with poor prognosis.
I-Ching Wang, Lucille Meliton, Xiaomeng Ren, Yufang Zhang, David Balli, Jonathan Snyder, Jeffrey A Whitsett, Vladimir V Kalinichenko, Tanya V Kalin   +8 more
doaj   +1 more source

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts

Cancer Cell International, 2010
Background Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice.
Easton Marilyn J, Yoon Lawrence W, George Michael, Moore Tanya M, Crosby Lynn M, Ni Hong, Morgan Kevin T, DeAngelo Anthony B   +7 more
doaj   +1 more source

In vitro studies on tumor-specific immunity by using C3H mammary cancer-A cells. I. Inhibitory effect of lymph-node cells from the tumor bearing isologous C3H mouse on the proliferation of the tumor cells [PDF]

, 1966
As a link in the series of studies on tumor-specific immunity, in vitro inhibitory effect of sensitized isologous lymph-node cells on the proliferation of C3H mammary cancer was studied.
Satoh, Katuaki
core   +1 more source

Avenanthramide C From Oats Possibly Exerts Anti‐Inflammatory Effects in Human Umbilical Vein Endothelial Cells

Journal of Food Science, Volume 91, Issue 1, January 2026.
ABSTRACT Chronic kidney disease (CKD) is associated with inflammation and cardiovascular complications and is partly exacerbated by the uremic toxin indoxyl sulfate (IS). IS is known to activate the aryl hydrocarbon receptor (AhR) to promote vascular inflammation.
Hiroyuki Sasaki, Hirofumi Masutomi, Hajime Nagasawa, Yuma Matsumoto, Teruyuki Okuma, Tomoyuki Otsuka, Katsuyuki Ishihara, Yusuke Suzuki, Seiji Ueda   +8 more
wiley   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
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