Results 71 to 80 of about 25,402 (289)

MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity

Journal of Extracellular Vesicles, Volume 13, Issue 10, October 2024.
Abstract Extracellular vesicles (EVs) mediate intercellular communication in many physiologic processes and can modulate immune responses in individuals with cancer. Most studies of EVs in cancer have focused on their tumour promoting properties.
Stephen C. Searles, Wei‐Shan Chen, Jarrod D. Yee, Preston Lee, Calvin K. Lee, Christine Caron, Felippe Mousovich‐Neto, Irina Matei, David Lyden, Jack D. Bui   +9 more
wiley   +1 more source

Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide

Journal for ImmunoTherapy of Cancer, 2021
Background NY-ESO-1 is a tumor-specific, highly immunogenic, human germ cell antigen of the MAGE-1 family that is a promising vaccine and cell therapy candidate in clinical trial development.
Vincenzo Cerundolo, Eugene Shenderov, Matheswaran Kandasamy, Uzi Gileadi, Jili Chen, Dawn Shepherd, James Gibbs, Gennaro Prota, Jonathan D Silk, Jonathan W Yewdell   +9 more
doaj   +1 more source

Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene

Journal of Experimental Medicine, 1979
The cellular origin of tumors induced by the chemical carcinogen 3- methylcholanthrene (MCA) was studied in mice with X-chromosome inactivation mosaicism.
L. Reddy, P. Fialkow
semanticscholar   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Preclinical evaluation of ELP‐004 in mice

Pharmacology Research &Perspectives, Volume 12, Issue 4, August 2024.
In vitro metabolic pathways of ELP‐004. Abstract This study provides a detailed understanding of the preclinical pharmacokinetics and metabolism of ELP‐004, an osteoclast inhibitor in development for the treatment of bone erosion. Current treatments for arthritis, including biological disease‐modifying antirheumatic drugs, are not well‐tolerated in a ...
Jamie L. McCall, Werner J. Geldenhuys, Lisa J. Robinson, Michelle R. Witt, Peter M. Gannett, Björn C. G. Söderberg, Harry C. Blair, Jonathan Soboloff, John B. Barnett   +8 more
wiley   +1 more source

Author Correction: Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Chih-Cheng Chang, Kuo-How Huang, Sung-Po Hsu, Yuan-Chii G. Lee, Yuh-Mou Sue, Shu-Hui Juan   +5 more
doaj   +1 more source

Catalytic activity of the membrane-bound methylcholanthrene-inducible cytochrome P-450 [PDF]

, 1985
The benzopyrene hydroxylase activity of the methylcholanthrene-inducible form of cytochrome P-450 (P-448) has been studied in native and reconstituted liver microsomal membranes.
Ammatuna, Emanuele, Bremer, Edwin, He, Yuan, Helfrich, Wijnand, Hendriks, Mark A. J. M., Huls, Gerwin, Samplonius, Douwe F., Schepel, Ilona, van Bommel, Peter E., van Ginkel, Robert J., van Meerten, Tom, Wiersma, Valerie R.   +11 more
core   +3 more sources

The components of the AhR‐molecular chaperone complex differ depending on whether the ligands are toxic or non‐toxic

FEBS Letters, Volume 598, Issue 12, Page 1478-1490, June 2024.
When bound to toxic or non‐toxic ligands, aryl hydrocarbon receptors (AhRs) are activated and nuclear translocation occurs; AhRs are bound to molecular chaperone complexes, AhR‐HSP90‐XAP2‐p23 for toxic ligands, whereas for non‐toxic ligands AhR‐HSP90‐ XAP2 for non‐toxic ligands. Toxic and non‐toxic ligand selectivity of AhR depends on the components of
Yukihiko Narita, Arisa Tamura, Shiori Hatakeyama, Seiya Uemura, Atsuko Miura, Asami Haga, Noriko Tsuji, Nozomi Fujie, Yukina Izumi, Taku Sugawara, Michiro Otaka, Ken Okamoto, Peng Lu, Suguru Okuda, Michio Suzuki, Koji Nagata, Hiroaki Shimizu, Hideaki Itoh   +17 more
wiley   +1 more source

Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents [PDF]

, 1981
Abelson murine leukemia virus (A-MuLV)-transformed cells, simian virus 40 (SV40)-transformed cells, and chemically transformed cells all have increased levels of a 50,000-molecular-weight host cell protein.
Baltimore, David, Boss, Michael A., Rotter, Varda   +2 more
core   +1 more source

Renal cortical drug and xenobiotic metabolism following urinary tract obstruction [PDF]

, 1984
Renal cortical drug and xenobiotic metabolism following urinary tract obstruction. Renal cortical metabolism of drugs and xenobiotics was assessed with microsomes prepared from normal, contralateral and 4-day postobstructive hydronephrotic kidneys ...
Davis, Bernard B., Mattammal, Michael B., Rapp, Neville S., Zenser, Terry V.   +3 more
core   +1 more source