Results 71 to 80 of about 17,936 (269)

Lack of WDFY4 leads to impaired immune response and poor cancer prognosis

The FASEB Journal, Volume 38, Issue 22, 30 November 2024.
This study used R language and multiple databases to jointly analyze the role of WDFY4 in cancer. Our analysis found that the WDFY4 gene and protein are differentially expressed in human tumors. WDFY4 causes prognostic differences in different directions in certain cancers.
Hanxuan Bao, Chen Zhang, Xue Peng, Jingnan Jia, Yi Yang   +4 more
wiley   +1 more source

Antibody formation for malignant tumor. II. Antigenicity of Ehrlich ascites tumor lipoprotein [PDF]

, 1970
A unique low density lipoprotein was obtained from the tumor transplanted with a cultured cell line of Ehrlich ascites tumor, JTC-ll cell. The tumor low density lipoprotein electrophoretically migrated as a single band, and the mobility was different ...
Okamura, Shinsuke, Tadatomo, Yasuo, Yamamoto, Yasuhisa   +2 more
core   +1 more source

Imaging‐Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids

Advanced Healthcare Materials, Volume 13, Issue 27, October 28, 2024.
The imaging‐based cancer immunotherapy evaluation platform facilitates systematic assessment of treatments through suitable in vitro models that closely mimic the human immune system. These evaluation methods enable a more precise and personalized approach in the development of cancer immunotherapy. Abstract Cancer immunotherapy is used to treat tumors
Seong‐Eun Kim, Suji Yun, Junsang Doh, Hong Nam Kim   +3 more
wiley   +1 more source

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

, 2018
An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver ...
Eo, Jinsu, Kang, Young Bok (Abraham), Mert, Safak, Usta, O. Berk, Yarmush, Martin L.   +4 more
core   +1 more source

Enhancement of drug oxidation and conjugation by carcinogens in different rat tissues [PDF]

, 1972
OBJECTIVE After endoscopic third ventriculostomy (ETV), some patients develop recurrent symptoms of hydrocephalus. The optimal treatment for these patients is not clear: repeat ETV (re-ETV) or CSF shunting.
Breimer, Gerben E., Brusse-Keizer, Marjolein, Buis, Dennis R., Dammers, Ruben, Delye, Hans, Hoving, Eelco W., Woerdeman, Peter A.   +6 more
core   +2 more sources

MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity

Journal of Extracellular Vesicles, Volume 13, Issue 10, October 2024.
Abstract Extracellular vesicles (EVs) mediate intercellular communication in many physiologic processes and can modulate immune responses in individuals with cancer. Most studies of EVs in cancer have focused on their tumour promoting properties.
Stephen C. Searles, Wei‐Shan Chen, Jarrod D. Yee, Preston Lee, Calvin K. Lee, Christine Caron, Felippe Mousovich‐Neto, Irina Matei, David Lyden, Jack D. Bui   +9 more
wiley   +1 more source

Cancer immunotherapy with surgery [PDF]

, 1977
With the recent advances in the immunological surveillance system, an understanding of the role of host immunity has become essential to the management of carcinogenesis, tumor proliferation, recurrence and metastasis.
Fukuda, Hanzo, Hayashi, Shigeo, Konaga, Eiji, Mannami, Tetsuya, Miwa, Hiroaki, Nakahara, Harutsugu, Orita, Kunzo, Uchida, Yoshio, Yumura, Masahito   +8 more
core   +1 more source

Preclinical evaluation of ELP‐004 in mice

Pharmacology Research &Perspectives, Volume 12, Issue 4, August 2024.
In vitro metabolic pathways of ELP‐004. Abstract This study provides a detailed understanding of the preclinical pharmacokinetics and metabolism of ELP‐004, an osteoclast inhibitor in development for the treatment of bone erosion. Current treatments for arthritis, including biological disease‐modifying antirheumatic drugs, are not well‐tolerated in a ...
Jamie L. McCall, Werner J. Geldenhuys, Lisa J. Robinson, Michelle R. Witt, Peter M. Gannett, Björn C. G. Söderberg, Harry C. Blair, Jonathan Soboloff, John B. Barnett   +8 more
wiley   +1 more source

The role of neutrophil myeloperoxidase in models of lung tumor development [PDF]

, 2014
Chronic inflammation plays a key tumor-promoting role in lung cancer. Our previous studies in mice demonstrated that neutrophils are critical mediators of tumor promotion in methylcholanthrene (MCA)-initiated, butylated hydroxytoluene (BHT)-promoted lung
Amy Rymaszewski, Andrew Gelman, Bellocq, Collins, Corp, Coussens, Di Stefano, Eheman, Everett Tate, Gungor, Guthrie, Hao Zhang, Haris Vikis, Houghton, Hoy, Jamieson, Jason Jarzembowski, Joannes Yimbesalu, Johansson, Kirkwood Pritchard Jr., Knaapen, Larsson, Lefkowitz, Lefkowitz, Malkinson, Malle, Melkamu, Meyer, Mika, Saed, Sethi, Vaguliene, Van Schooten, Witschi, Yang, Zhang   +35 more
core   +3 more sources

The components of the AhR‐molecular chaperone complex differ depending on whether the ligands are toxic or non‐toxic

FEBS Letters, Volume 598, Issue 12, Page 1478-1490, June 2024.
When bound to toxic or non‐toxic ligands, aryl hydrocarbon receptors (AhRs) are activated and nuclear translocation occurs; AhRs are bound to molecular chaperone complexes, AhR‐HSP90‐XAP2‐p23 for toxic ligands, whereas for non‐toxic ligands AhR‐HSP90‐ XAP2 for non‐toxic ligands. Toxic and non‐toxic ligand selectivity of AhR depends on the components of
Yukihiko Narita, Arisa Tamura, Shiori Hatakeyama, Seiya Uemura, Atsuko Miura, Asami Haga, Noriko Tsuji, Nozomi Fujie, Yukina Izumi, Taku Sugawara, Michiro Otaka, Ken Okamoto, Peng Lu, Suguru Okuda, Michio Suzuki, Koji Nagata, Hiroaki Shimizu, Hideaki Itoh   +17 more
wiley   +1 more source