Results 141 to 150 of about 1,912 (187)

Cytotoxicity and genotoxicity of methyleugenol and related congeners — a mechanism of activation for methyleugenol

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
Methyleugenol is a substituted alkenylbenzene found in a variety of foods, products, and essential oils. In a 2-year bioassay conducted by the National Toxicology Program, methyleugenol caused neoplastic lesions in the livers of Fischer 344 rats and B6C3F(1) mice. We were interested in the cytotoxicity and genotoxicity caused by methyleugenol and other
John-Michael Sauer, Charlène A McQueen, C A McQueen   +2 more
exaly   +3 more sources

Constituents of aromatic plants: I. Methyleugenol

Fìtoterapìâ, 2000
Methyleugenol (ME) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents. Its occurrence, routes of intake, and available information on toxicity, kinetics and metabolism are reviewed. In view of the carcinogenic potential of ME, the need to check its presence in food products with effective
Beatrice Scazzocchio, Marco Silano
exaly   +3 more sources

Methyleugenol as a surgical anesthetic in rodents

Experientia, 1981
The in vivo administration of 59Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.
Elisaldo Carlini
exaly   +4 more sources

Reduction of Safrole and Methyleugenol in Asari radix et rhizoma by Decoction

Forschende Komplementärmedizin / Research in Complementary Medicine, 2009
Asari radix et rhizoma (Xixin, Manchurian Wildginger, Asarum spp) is a herbal drug commonly used as an ingredient in traditional Chinese medicine (TCM). Many species of Asarum contain safrole and methyleugenol as the main components of their volatile oils.
Chen C, Spriano D, Lehmann T, Meier B
openaire   +4 more sources

Synthesis, structure and properties of two series of platinum(II) complexes containing methyleugenol or chelating methyleugenol and amine

Polyhedron, 2015
Two series of platinum(II) complexes of the formula [PtCl2(Meug)(Amine)] (1–6, Meug: methyleugenol) and [PtCl(Meug-1H)(Amine)] (7–13, Meug-1H: deprotonated methyleugenol) were synthesized and characterized by elemental analyses, IR,
Peter Mangwala Kimpende, Nguyen Huu Dinh, Nguyen Thi Thanh Chi   +2 more
exaly   +2 more sources

Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice

European Journal of Pharmacology, 2006
The effects of methyleugenol, an essential oil isolated from Asiasari radix, on antinociception were examined using the formalin test in mice. Oral administration of 10 mg/kg methyleugenol significantly decreased the duration of licking and biting behavior in the second phase without affecting that of the first phase, as did diclofenac, a non-steroidal
Ken-Ichi Miyamoto, Masaki Aburada, Yoshio Kase   +2 more
exaly   +3 more sources

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat

Toxicology in Vitro, 2011
The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene methyleugenol in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature. The model was based on the model previously developed
Al-Subeihi, A.A., Spenkelink, A., Rachmawati, N., Boersma, M.G., Punt, A., Vervoort, J.J.M., van Bladeren, P.J., Rietjens, I.M.C.M.   +7 more
openaire   +3 more sources

Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast

Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental Or Occupational Exposure, 1989
Deletion of an integrated plasmid, a specific type of intrachromosomal recombination, was evaluated for inducibility with the phenylpropenes safrole, eugenol and methyleugenol in the yeast Saccharomyces cerevisiae. These phenylpropenes are found in food products, spices, pharmaceuticals and clove cigarettes. Safrole and eugenol are known carcinogens in
R Daniel Gietz, Robert Schiestl, P J Hastings   +2 more
exaly   +3 more sources

Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases

Archives of Toxicology, 2015
Methyleugenol is a substituted alkenylbenzene found in several herbs and spices. It is classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed the biological mechanism of the genotoxic properties of methyleugenol and its oxidative metabolites.
Doris Marko, Melanie Esselen
exaly   +3 more sources

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Food and Chemical Toxicology, 2019
The presence and accompanying risks of methyleugenol and eugenol in herbal beverages available on the Indonesian market were evaluated. Methyleugenol was detected in 49 out of 114 samples, at levels amounting to 2.6–443.7 μg/g, while 4 samples contained ...
Suparmi Suparmi, Sebastiaan Wesseling, Ivonne M. C. M. Rietjens   +2 more
exaly   +2 more sources