Results 151 to 160 of about 1,912 (187)
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Journal of Agricultural and Food Chemistry, 2018
Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
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Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
openaire +2 more sources
Food & Function, 2012
Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
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Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
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Anesthetic Action of Methyleugenol and Other Eugenol Derivatives
Pharmacology, 2008A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica pagans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be the most active and the less toxic ...
A B, Sell, E A, Carlini
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Methyleugenol hepatocellular cancer initiating effects in rat liver
Food and Chemical Toxicology, 2013Methyleugenol (MEG), a constituent of plants used in the human diet, is hepatocarcinogenic in rodents. In an experiment to elucidate its mode of action in rat liver, male F344 rats were administered MEG intragastrically at 3 doses per week for up to 16 weeks in an initiation phase, after which half the rats were fed 500 ppm phenobarbital (PB) in the ...
Gary M, Williams +3 more
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Methyleugenol in Ocimum basilicum L. Cv. Genovese Gigante
Journal of Agricultural and Food Chemistry, 2000Ocimum basilicum cv. Genovese Gigante is the basil cultivar used the most in the production of a typical Italian sauce called pesto. The aromatic composition of plants at different growth stages was determined. Plants from different areas of northwestern Italy were analyzed at 4 and 6 weeks after sowing and showed methyleugenol and eugenol as the main ...
MIELE M. +3 more
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Suppression ofl-Histidine Decarboxylase mRNA Expression by Methyleugenol
Biochemical and Biophysical Research Communications, 1997We investigated the effect of methyleugenol on anaphylaxis. Methyleugenol completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. Methyleugenol also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, methyleugenol dose-dependently inhibited histamine release in mast cells activated by compound 48/80 or
B K, Shin, E H, Lee, H M, Kim
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Electrophysiological Characterization of Methyleugenol: A Novel Agonist of GABA(A) Receptors
ACS Chemical Neuroscience, 2014Methyleugenol (ME) is a natural constituent isolated from many plant essential oils having multiple biological effects including anticonvulsant and anesthetic activities, although the underlying mechanisms remain unclear. Here, we identify ME as a novel agonist of ionotropic γ-aminobutyric acid (GABA) receptors.
Jing, Ding +9 more
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Toxicology and Applied Pharmacology, 2015 The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into account ...
Ans Punt +2 more
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Mechanistic Insight into Difference in Hepatotoxicity of Methyleugenol and Safrole
Journal of Agricultural and Food ChemistryMethyleugenol (MTL) and safrole (SFL) are hepatotoxic flavorants with distinct IARC classifications (Group 2A versus 2B), and yet the structural reason for this differential toxicity is unclear. Results showed that MTL was more hepatotoxic than SFL, owing to its more efficient metabolic activation.
Hui Yang +7 more
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Chemical Interaction of Protein Cysteine Residues with Reactive Metabolites of Methyleugenol
Chemical Research in Toxicology, 2017Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced toxicities.
Yukun Feng +5 more
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