Results 151 to 160 of about 1,735 (188)
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Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases
Archives of Toxicology, 2015Methyleugenol is a substituted alkenylbenzene found in several herbs and spices. It is classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed the biological mechanism of the genotoxic properties of methyleugenol and its oxidative metabolites.
Doris Marko +2 more
exaly +3 more sources
Chemical Interaction of Protein Cysteine Residues with Reactive Metabolites of Methyleugenol
Chemical Research in Toxicology, 2017 Methyleugenol (ME), an alkenylbenzene compound, is a natural ingredient of several herbs and is used as flavoring agent in foodstuffs and fragrance in cosmetics. The hepatotoxicity, cytotoxicity, and carcinogenesis of ME have been well documented, and metabolic activation has been suggested to involve in ME-induced toxicities.
Yukun Feng +5 more
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Methyleugenol reduces cerebral ischemic injury by suppression of oxidative injury and inflammation
Free Radical Research, 2010The present study tested the cytoprotective effect of methyleugenol in an in vivo ischemia model (i.e. middle cerebral artery occlusion (MCAO) for 1.5 h and subsequent reperfusion for 24 h) and further investigated its mechanism of action in in vitro cerebral ischemic models.
Geum-Sil Cho +2 more
exaly +3 more sources
In vitro synergy of eugenol and methyleugenol with fluconazole against clinical Candida isolates
Journal of Medical Microbiology, 2010 The speciesCandidais a group of opportunistic pathogenic commensals in immune-compromised patients. Treatment ofCandidainfections is becoming increasingly difficult due to antifungal drug resistance, especially with fluconazole (FLC), which is a commonly used azole. In the present study thein vitroantifungal activity of eugenol (EUG) and methyleugenol (
Aijaz, Ahmad +3 more
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Food and Chemical Toxicology, 2019 The presence and accompanying risks of methyleugenol and eugenol in herbal beverages available on the Indonesian market were evaluated. Methyleugenol was detected in 49 out of 114 samples, at levels amounting to 2.6–443.7 μg/g, while 4 samples contained ...
Suparmi Suparmi, Ivonne M C M Rietjens
exaly +2 more sources
Toxicology and Applied Pharmacology, 2015 The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into account ...
Wasma Alhusainy +2 more
exaly +2 more sources
Journal of Agricultural and Food Chemistry, 2018
Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
openaire +2 more sources
Methyleugenol (ME), a natural ingredient of several herbs and spices used in the human diet, is hepatocarcinogenic in rodents. Following metabolic activation to the reactive carbocation intermediate, ME can bind covalently to DNA, which is directly associated with its carcinogenicity.
Yukun Feng +4 more
openaire +2 more sources
Food & Function, 2012
Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
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Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 cells.
Isabel Anna Maria, Groh +6 more
openaire +2 more sources
Anesthetic Action of Methyleugenol and Other Eugenol Derivatives
Pharmacology, 2008A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica pagans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be the most active and the less toxic ...
A B, Sell, E A, Carlini
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