Results 121 to 130 of about 28,399 (260)
Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]
, 2013 Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy +19 more
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Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Molecular Metabolism, 2018 Objectives The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications.
D. Schumacher +8 more
semanticscholar +1 more source
The Journal of biological chemistry, 1999 Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products. In the present study, we identify a novel MG-arginine adduct and also characterize the structure of a major fluorescent adduct.
T, Oya +6 more
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Inhibitory effect of vanillic acid on methylglyoxal-mediated glycation in apoptotic Neuro-2A cells
, 2014 Methylglyoxal is a reactive dicarbonyl compound generated as an intermediate of glycolysis during the physical glycation in the diabetic condition.
Shih, P.H. +6 more
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Metabolism of Methylglyoxal by Scenedesmus Quadricauda [PDF]
, 1970 The purpose of this study was to investigate the metabolic pathways of methylglyoxal in S ...
Rounsavall, Terry Yale
core
, 2015 Methylglyoxal is a dicarbonyl compound that acts as a toxic electrophile in biological systems. Methylglyoxal is produced in certain bacteria as a byproduct of glycolysis through methylglyoxal synthase.
Zhang, May M. +3 more
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Utilization of Methylglyoxal in Animal Tissues
Experimental Biology and Medicine, 1957 SummaryMethylglyoxal has been incubated with rat liver extracts in the presence of kidney antiglyoxalase. During incubation, methylglyoxal and inorganic P decrease, whereas total hydrolyzable P increases. The hydrolysis curve of the Ba insoluble fraction of liver incubated with methylglyoxal resembles that obtained from hexose phosphate.
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Cancerostatic Action of Methylglyoxal [PDF]
Science, 1968 L G, Együd, A, Szent-Györgyi
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Adaptive response of human melanoma cells to methylglyoxal injury.
, 1998 -The effects of methylglyoxal on the growth of a line of human melanoma cells are investigated. Methylglyoxal inhibits cell growth in a dose-dependent manner and causes an increase in glyceraldehyde 3-phosphate dehydrogenase, and glyoxalase 1 and ...
POMA AMMA +6 more
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Effect of methylglyoxal and edaravone on reactive oxygen species production.
, 2014 Time-dependent effect of methylglyoxal (MG; 600 µM) on ROS production of human brain endothelial cells (hCMEC/D3) (A). Effect of co-treament with 600 µM methylglyoxal and 3 mM edaravone (MG + E) or 2 mM aminoguanidine (MG + AG) after 4 hours (B ...
Fruzsina R. Walter (599801) +11 more
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