Results 111 to 120 of about 28,399 (260)

Determination of toxic α-dicarbonyl compounds in sesame oils using dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry

Food Chemistry: X
Glyoxal, methylglyoxal, and diacetyl are toxic α-dicarbonyl compounds found in heat-processed foods, including edible oils. Dispersive liquid–liquid microextraction was combined with gas chromatography mass spectrometry to determine the glyoxal ...
Jangho Lee, Tae Gyu Nam, Hyo-Kyoung Choi, Hae Won Jang   +3 more
doaj   +1 more source

Brain Senescence Caused by Elevated Levels of Reactive Metabolite Methylglyoxal on D-Galactose-Induced Aging Mice

Frontiers in Neuroscience, 2019
Aging is a complex natural phenomenon that is manifested by degenerative changes in the structure and function of cells and tissues. D-Galactose-induced aging mice are an artificial accelerated aging model that causes memory and learning impairment ...
Hong Li, Ling-bing Zheng, Chao Chen, Xiao-Li Liu, Wen-Shen Zhang   +4 more
semanticscholar   +1 more source

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

, 2017
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are two important leading causes of acquired blindness in developed countries. As accumulation of advanced glycation end products (AGEs) in retinal pigment epithelial (RPE) cells plays ...
林琬琬, Chan, Chi-Ming;Huang, Duen-Yi;Huang, Yi-Pin;Hsu, Shu-Hao;Kang, Lan-Ya;Shen, Chung-Min;Lin, Wan-Wan   +1 more
core   +1 more source

Investigation of Methylglyoxal, soluble Receptor for Advanced Glycation End-products, and Malondialdehyde in Type 2 Diabetes Mellitus with and Without Cardiovascular Risk Factors

Diyala Journal of Medicine
Background: Type 2 diabetes mellitus is a chronic metabolic illness that significantly increases the probability of cardiovascular disorders among individuals with type 2 diabetes.
Weaam F. Hussien, Estabraq A. R. Al-Wasiti, Mahood. Sh. Khudair, Hayder A. AL-Aubaidy   +3 more
doaj   +1 more source

Morphofunctional mitochondrial response to methylglyoxal toxicity in Bufo bufo embryos.

, 2001
Methylglyoxal (2-oxopropanal) is a reactive alpha-oxoaldehyde that can be formed endogenously mainly as a by-product of glycolytic pathway. It is a cytotoxic compound with significant antiproliferative properties as it can bind, under physiological ...
COLAFARINA S, CESARE, Patrizia, AMICARELLI F, AIMOLA P, DI ILIO C, MIRANDA M, RAGNELLI AM   +6 more
core   +1 more source

Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

Molecules, 2014
The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to
Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz   +2 more
doaj   +1 more source

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

International Journal of Molecular Sciences, 2017
The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation. Nonetheless, MGO levels are also increased as consequence of the ineffective action
C. Nigro, A. Leone, G. A. Raciti, M. Longo, P. Mirra, P. Formisano, F. Beguinot, C. Miele   +7 more
semanticscholar   +1 more source

Enhanced Formation of Methylglyoxal-Derived Advanced Glycation End Products in Arabidopsis Under Ammonium Nutrition

Frontiers in Plant Science, 2018
Nitrate (NO3–) and ammonium (NH4+) are prevalent nitrogen (N) sources for plants. Although NH4+ should be the preferred form of N from the energetic point of view, ammonium nutrition often exhibits adverse effects on plant physiological functions and ...
Klaudia Borysiuk, Monika Ostaszewska-Bugajska, Marie-Noëlle Vaultier, Marie-Paule Hasenfratz-Sauder, Bożena Szal   +4 more
doaj   +1 more source

Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models

Frontiers in Toxicology
BackgroundAcetaldehyde and methylglyoxal are structurally related aldehydes produced by thermal degradation of the electronic cigarette (EC) solvents, propylene glycol and glycerin.
Man Wong, Teresa Martinez, Nathan Hendricks, Prue Talbot   +3 more
doaj   +1 more source

Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats

Molecules, 2019
Advanced glycation end products (AGEs) is a causative factor of various chronic diseases, including chronic kidney disease and atherosclerosis. AGE inhibitors, such as aminoguanidine and pyridoxamine, have the therapeutic activities for reversing the ...
Eunsoo Jung, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, Junghyun Kim   +4 more
doaj   +1 more source