Results 101 to 110 of about 18,817 (217)
Characterization of the Deoxyguanosine–Lysine Cross-Link of Methylglyoxal
, 2015 Methylglyoxal is a mutagenic bis-electrophile that is produced endogenously from carbohydrate precursors. Methylglyoxal has been reported to induce DNA–protein cross-links (DPCs) in vitro and in cultured cells.
Donald F. Stec (1265898) +3 more
core +1 more source
Utilization of Methylglyoxal in Animal Tissues
Experimental Biology and Medicine, 1957 SummaryMethylglyoxal has been incubated with rat liver extracts in the presence of kidney antiglyoxalase. During incubation, methylglyoxal and inorganic P decrease, whereas total hydrolyzable P increases. The hydrolysis curve of the Ba insoluble fraction of liver incubated with methylglyoxal resembles that obtained from hexose phosphate.
openaire +2 more sources
Adaptive response of human melanoma cells to methylglyoxal injury.
, 1998 -The effects of methylglyoxal on the growth of a line of human melanoma cells are investigated. Methylglyoxal inhibits cell growth in a dose-dependent manner and causes an increase in glyceraldehyde 3-phosphate dehydrogenase, and glyoxalase 1 and ...
POMA AMMA +6 more
core
Cancerostatic Action of Methylglyoxal [PDF]
Science, 1968 L G, Együd, A, Szent-Györgyi
openaire +2 more sources
Cytotoxic action of methylglyoxal on insulin-secreting cells
, 2001 Methylglyoxal is a spontaneous product of glucose metabolism which is known to have cytotoxic actions and to be present in raised concentrations in hyperglycaemia. It could therefore play an important role in glucose toxicity.
Elizabeth A. Sheader +5 more
core +1 more source
Frontiers in NanotechnologyThe nonenzymatic glycation process initiates a harmful cycle that generates various intermediate compounds, leading to carbonyl and oxidative stress, and ultimately resulting in the formation of advanced glycation end products (AGEs).
Saheem Ahmad +10 more
doaj +1 more source
, 2014 Endothelial dysfunction such as hyper permeability is one of the char acteristics in an earlystage of diabetic complicatio ns. Curcumin has been sho wn to inhibit the formation ofadv anced glycation end products (AGEs)and to trap meth yglyo xal (MGO) in ...
Te-Y u Hu +3 more
core +1 more source
Toxicity of methylglyoxal towards rat enterocytes and colonocytes
, 1990 Effect of methylglyoxal, a bacterial metabolic product, on protein, DNA, and RNA synthesis in rat enterocytes and colonocytes was investigated. Results showed that 1 mM methylglyoxal inhibited protein, DNA, and RNA synthesis to the extent of 65-85, 65-80,
Baskaran, S., Balasubramanian, K. A.
core +2 more sources
, 2015 Aparajita Pal,1,* Dipa Talukdar,1,* Anirban Roy,1 Subhankar Ray,2 Asish Mallick,3 Chitra Mandal,3 Manju Ray1 1Department of Biophysics, Bose Institute, Kolkata, India; 2Department of Biochemistry, University of Calcutta, Kolkata, India; 3Cancer Biology ...
Talukdar D +6 more
core
Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications
HypertensionBACKGROUND: Preeclampsia is a multifaceted syndrome that includes maternal vascular dysfunction. We hypothesize that increased placental glycolysis and hypoxia in preeclampsia lead to increased levels of methylglyoxal (MGO), consequently causing vascular dysfunction. METHODS:
Philippe Vangrieken +8 more
openaire +2 more sources