Results 101 to 110 of about 28,399 (260)
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10195-10209, November 2026.ABSTRACT Aims Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus (T2DM), driven in part by oxidative stress and the accumulation of advanced glycation end products (AGEs). Oleanolic acid (OA), a natural triterpene present in olive‐derived matrices, may modulate AGE metabolism.
Aída García‐González +14 more
wiley +1 more source
Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
bioRxiv, 2019 Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with general chromatin ...
Qing-Fei Zheng +2 more
semanticscholar +1 more source
Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen +8 more
wiley +1 more source
Thermodynamics and Kinetics of Methylglyoxal Dimer Formation: A Computational Study
, 2009 Density functional theory (B3LYP//6-311+G*) calculations, including Poisson−Boltzmann implicit solvent and free energy corrections, are applied to study the hydration of methylglyoxal and the subsequent formation of dimeric species in solution.
Kua, Jeremy +8 more
core +2 more sources
Methylglyoxal metabolism in trypanosomes and leishmania
Seminars in Cell & Developmental Biology, 2011 Methylglyoxal is a toxic by-product of glycolysis and other metabolic pathways. In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6).
Wyllie, Susan, Fairlamb, Alan H.
openaire +3 more sources
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
Redox Biology, 2018 The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection.
Joel R. Frandsen +1 more
doaj +1 more source
The dataset of methylglyoxal activating p38 and p44/42 pathway in osteoclast
Data in Brief, 2019 Diabetes mellitus (DM) is a kind of chronic metabolic disease that could be characterized by uncontrollable high blood glucose (hyperglycemia) over a prolonged period and diverse complications in various organs.
Kwan Ming Lee +4 more
doaj +1 more source
Characterization of the Deoxyguanosine–Lysine Cross-Link of Methylglyoxal
, 2015 Methylglyoxal is a mutagenic bis-electrophile that is produced endogenously from carbohydrate precursors. Methylglyoxal has been reported to induce DNA–protein cross-links (DPCs) in vitro and in cultured cells.
Donald F. Stec (1265898) +3 more
core +1 more source
Cytotoxic action of methylglyoxal on insulin-secreting cells
, 2001 Methylglyoxal is a spontaneous product of glucose metabolism which is known to have cytotoxic actions and to be present in raised concentrations in hyperglycaemia. It could therefore play an important role in glucose toxicity.
Elizabeth A. Sheader +5 more
core +1 more source
Enhanced calcium entry via activation of NOX/PKC underlies increased vasoconstriction induced by methylglyoxal [PDF]
, 2018 Advanced glycation end-products (AGEs) play a pivotal role in macro- and micro-vascular diabetic complications. We investigated the mechanism by which methylglyoxal (an endogenous generator of AGEs) affects vascular contractility using the isolated ...
Sharib, Alaa Abu +4 more
core +1 more source