Results 81 to 90 of about 18,817 (217)
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.The phenolic composition of Rhus coriaria fruits has been comprehensively characterized and linked to a variety of biological activities, including antioxidant, anti‐glycation, enzyme‐inhibitory, and cytoprotective effects. These findings highlight the functional potential of Sicilian sumac as a valuable source of health‐promoting phytochemicals ...
Katia Arena +6 more
wiley +1 more source
Volatile Organic Compounds in Rainwater: A New Frontier in Atmosphere–Biosphere Interactions
Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 9, September 2026.Abstract Rainwater is a key vector of atmospheric deposition, linking the atmosphere with terrestrial and aquatic ecosystems. While the inorganic chemistry of precipitation (dominated by sulfate, nitrate, ammonium, and trace metals) has been extensively studied, organic compounds in rainwater have received less attention, and Volatile Organic Compounds
Ana M. Yáñez‐Serrano +6 more
wiley +1 more source
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek +1 more
wiley +1 more source
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
Redox Biology, 2018 The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection.
Joel R. Frandsen +1 more
doaj +1 more source
Chebulic Acid Prevents Methylglyoxal-Induced Mitochondrial Dysfunction in INS-1 Pancreatic β-Cells
Antioxidants, 2020 To investigate the anti-diabetic properties of chebulic acid (CA) associated with the prevention of methyl glyoxal (MG)-induced mitochondrial dysfunction in INS-1 pancreatic β-cells, INS-1 cells were pre-treated with CA (0.5, 1.0, and 2.0 μM) for 48 h ...
Hyun-jung Yoo +3 more
doaj +1 more source
Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice
Physiological Reports, Volume 14, Issue 17, September 2026.Loss of glyoxalase 1 has a minimal impact on protein glycation in a murine model for metabolic syndrome. These mice have reduced hepatic steatosis despite impaired glucose handling. Abstract We demonstrate the generation and characterization of the methylglyoxal detoxifying enzyme, glyoxalase 1, knockout mice (Glo1−/−).
Emely A. Hoffman +16 more
wiley +1 more source
Methylglyoxal metabolism in trypanosomes and leishmania
Seminars in Cell & Developmental Biology, 2011 Methylglyoxal is a toxic by-product of glycolysis and other metabolic pathways. In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6).
Wyllie, Susan, Fairlamb, Alan H.
openaire +3 more sources
The dataset of methylglyoxal activating p38 and p44/42 pathway in osteoclast
Data in Brief, 2019 Diabetes mellitus (DM) is a kind of chronic metabolic disease that could be characterized by uncontrollable high blood glucose (hyperglycemia) over a prolonged period and diverse complications in various organs.
Kwan Ming Lee +4 more
doaj +1 more source
Trapping of methylglyoxal by dietary compounds in vitro
, 2007 The importance of reactive dicarbonyl speices has been raising because of its link to many health complications. Diabetes, with the high prevalence and continued investigation on its link to methylglyoxal interested us to initiate this study.
core +1 more source
Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease
, 2019 Purpose of reviewChronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments.
Schalkwijk, Casper G.; id_orcid +4 more
core +1 more source