Results 71 to 80 of about 16,994 (228)
Journal of Diabetes Investigation, EarlyView.Ultrasound‐measured plantar fascia thickness is associated with microvascular complications and glycemic control in individuals with type 1 diabetes, suggesting PFT as a potential non‐invasive tool for clinical assessment. In addition, improved thickness values were observed in patients using automated insulin delivery systems.
Giulia Casadei +9 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Glutathione, including reduced glutathione (GSH) and oxidized glutathione (GSSG), is the major non‐protein thiol‐based redox buffer. There are diurnal rhythms in total glutathione level and in this work, we investigate whether these oscillations might be indicative of circadian regulation of total glutathione homeostasis.
Desiré Cano‐Yelo +5 more
wiley +1 more source
Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective
VIEW Medicine, Volume 1, Issue 1, August 2026.Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng +3 more
wiley +1 more source
Cells Producing Their Own Nemesis: Understanding Methylglyoxal Metabolism
, 2014 Methylglyoxal, which is technically known as 2-oxopropanal or pyruvaldehyde, shows typical reactions of carbonyl compounds as it has both an aldehyde and a ketone functional group. It is an extremely cytotoxic physiological metabolite, which is generated
Chakravortty, Dipshikha +5 more
core +1 more source
Methylglyoxal Binding to Bovine Liver Catalase Results in Loss of Activity and Heme Dislocation
Trends in Peptide and Protein Sciences, 2019 Glycation, the non-enzymatic attachment of glucose to protein, is one of the important events in the pathophysiology of diabetes mellitus, Alzheimer’s, Parkinson’s and other diseases.
Subramanian Sivakami +4 more
doaj +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.Tendon injuries in diabetes heal poorly, with unclear drivers of extracellular matrix disruption and altered mechanics. This narrative review synthesizes in vitro, animal, and human studies, highlighting serum advanced glycation end products as potential systemic contributors.
Eric J. Gutierrez +3 more
wiley +1 more source
A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells
, 2013 Methylglyoxal is one of the most powerful glycating agents of proteins and other important cellular components and has been shown to be toxic to cultured cells.
ANTOGNELLI, Cinzia +3 more
core +1 more source
Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms
British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl +3 more
wiley +1 more source
Effect of protein glycation by methylglyoxal on pancreatic beta cell function [PDF]
Methylglyoxal is a physiological dicarbonyl metabolite and potent argininedirected glycating agent. It often modifies proteins at functional sites producing loss of positive charge, structural distortion and inactivation.
Tym, Amy
core
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes [PDF]
, 2018 Monocyte activation and polarization play essential roles in many chronic inflammatory diseases. An imbalance of M1 and M2 macrophage activation (pro-inflammatory and alternatively activated, respectively) is believed to be a key aspect in the etiology ...
Michael S. McGrath +9 more
core +1 more source