Results 61 to 70 of about 16,994 (228)

Vescalagin from Pink Wax Apple (Syzygium samarangense (Blume) Merrill and Perry) Protects Pancreatic β-Cells against Methylglyoxal-Induced Inflammation in Rats

Plants, 2021
Methylglyoxal (MG) is the primary precursor of advanced glycation end products involved in the pathogenesis of inflammation and diabetes. A previous study in our laboratory found anti-inflammatory and anti-hyperglycemic effects of the polyphenol ...
Wen-Chang Chang, James Swi-Bea Wu, Szu-Chuan Shen   +2 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Formation of methylglyoxal by bacteria isolated from human faeces

, 1989
Bacteria present in the human gut may produce methylglyoxal - a cytotoxic substance in mammals. This was investigated by studying the activity of methylglyoxal synthase, which produces methylglyoxal from dihydroxyacetone phosphate, and methylglyoxal ...
Prasanna Rajan, D., Baskaran, S., Balasubramanian, K. A.   +2 more
core   +1 more source

Prebiotic aqueous reactions catalyzed by native nickel without hydrogen

The FEBS Journal, EarlyView.
Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia, Max Brabender, William F. Martin   +2 more
wiley   +1 more source

Methylglyoxal and the brain microcirculation:the source matters [PDF]

The small blood vessels in the brain are crucial for maintaining healthy brain function. When these vessels are affected by disease, a condition called cerebral small vessel disease, it is common in older adults.
Berends, Eline
core   +1 more source

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEEndothelial dysfunction is a feature of hypertension and diabetes. Methylglyoxal (MG) is a reactive dicarbonyl metabolite of glucose and its levels are elevated in spontaneously hypertensive rats and in diabetic patients. We investigated if MG induces endothelial dysfunction and whether MG scavengers can prevent endothelial ...
Arti, Dhar, Indu, Dhar, Kaushik M, Desai, Lingyun, Wu   +3 more
openaire   +2 more sources

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

Methylglyoxal Uptake Coefficients on Aqueous Aerosol Surfaces

, 2018
In order to predict the amount of secondary organic aerosol formed by heterogeneous processing of methylglyoxal, uptake coefficients (γ) and estimates of uptake reversibility are needed.
Jean-François Doussin (2033350), David O. De Haan, Pangui, Edouard, Doussin, Jean-Francois, de Loera, Alexia, Alexia de Loera, Edouard Pangui, Natalie G. Jimenez, de Haan, David, Gratien, Aline, Cazaunau, Mathieu, Aline Gratien, Aline Gratien (2011024), Natalie G. Jimenez (4107985), Jimenez, Natalie, Jean-François Doussin, De Haan, David O., Mathieu Cazaunau, Jimenez, Natalie G., David O. De Haan (1306281), Alexia de Loera (4012562), Mathieu Cazaunau (1414612), Edouard Pangui (3482216)   +22 more
core   +1 more source

4‐1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions

Immunology &Cell Biology, EarlyView.
4‐1BB is a highly expressed TNFRSF co‐stimulatory receptor on MAIT cells upon activation. Expression and signaling via 4‐1BB enhance activation and provide co‐stimulation, boosting MAIT cell effector responses to TCR‐mediated activation. ABSTRACT Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that recognize microbe ...
Lamichhane R, Williams J, Tirand C, Fouillé R, Wedlock LE, Poudel A, Webley MC, Hannaway RF, Ussher JE   +8 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources