Results 61 to 70 of about 18,817 (217)
The FEBS Journal, EarlyView.In Colletotrichum acutatum species complex, conserved ring‐cleavage dioxygenases located adjacent to AA5_2 enzymes were investigated as potential redox partners. Biochemical analyses identified the dioxygenases as intradiol‐cleaving enzymes preferentially oxidizing methyl‐substituted catechols, while AA5_2 enzymes displayed weak alcohol oxidase ...
Radka Končitíková +7 more
wiley +1 more source
Alteration of subgingival microbiome in patients with type 2 diabetes induced by diabetes treatment
Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims/Introduction Diabetes and periodontal disease, a bacterial infection involving the oral microbiome, have a bidirectional relationship. However, the relationship between poor glycemic control and the oral microbiome remains unclear. The aim of this study was to assess the direct effect of intensive glycemic control on the oral microbiome ...
Moe Inoue +13 more
wiley +1 more source
Formation of methylglyoxal by bacteria isolated from human faeces
, 1989 Bacteria present in the human gut may produce methylglyoxal - a cytotoxic substance in mammals. This was investigated by studying the activity of methylglyoxal synthase, which produces methylglyoxal from dihydroxyacetone phosphate, and methylglyoxal ...
Prasanna Rajan, D. +2 more
core +1 more source
Plants, 2021 Methylglyoxal (MG) is the primary precursor of advanced glycation end products involved in the pathogenesis of inflammation and diabetes. A previous study in our laboratory found anti-inflammatory and anti-hyperglycemic effects of the polyphenol ...
Wen-Chang Chang +2 more
doaj +1 more source
Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing
The Journal of Physiology, EarlyView.Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley +1 more source
Mucosal‐Associated Invariant T Cells in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao +5 more
wiley +1 more source
Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose [PDF]
British Journal of Pharmacology, 2010 BACKGROUND AND PURPOSEEndothelial dysfunction is a feature of hypertension and diabetes. Methylglyoxal (MG) is a reactive dicarbonyl metabolite of glucose and its levels are elevated in spontaneously hypertensive rats and in diabetic patients. We investigated if MG induces endothelial dysfunction and whether MG scavengers can prevent endothelial ...
Arti, Dhar +3 more
openaire +2 more sources
Methylglyoxal and the brain microcirculation:the source matters [PDF]
The small blood vessels in the brain are crucial for maintaining healthy brain function. When these vessels are affected by disease, a condition called cerebral small vessel disease, it is common in older adults.
Berends, Eline
core +1 more source
Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu +3 more
wiley +1 more source
The formation of methylglyoxal from triose phosphates [PDF]
European Journal of Biochemistry, 1993 In Krebs‐Ringer phosphate buffer, the rate of formation of methylglyoxal from glycerone phosphate and glyceraldehyde 3‐phosphate was first order with respect to the triose phosphate with rates constant values of 1.94 ± 0.02 × 10−5 s−1 (n= 18) and 1.54 ± 0.02 × 10−4 s−1 (n= 18) at 37°C, respectively. The rate of formation of methylglyoxal from glycerone
S A, Phillips, P J, Thornalley
openaire +2 more sources