Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells [PDF]
, 2016 Background and Objectives: Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the
González Rivas, C. +17 more
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The role of the thiol group in protein modification with methylglyoxal [PDF]
Journal of the Serbian Chemical Society, 2009 Methylglyoxal is a highly reactive α-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction
Aćimović Jelena M. +2 more
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Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]
, 2014 The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila +11 more
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Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation
Frontiers in Neuroscience, 2017 Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor ...
Ryan B. Griggs +7 more
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Rapid and Reliable HPLC Method for the Simultaneous Determination of Dihydroxyacetone, Methylglyoxal and 5-Hydroxymethylfurfural in Leptospermum Honeys. [PDF]
PLoS ONE, 2016 A reliable determination of dihydroxyacetone, methylglyoxal and 5-hydroxymethylfurfural is essential to establishing the commercial value and antimicrobial potential of honeys derived from the Leptospermum species endemic to Australia and New Zealand. We
Matthew Pappalardo +2 more
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Methylglyoxal Influences Development of Caenorhabditis Elegans via Heterochronic Pathway [PDF]
, 2017 Methylglyoxal is a highly reactive dicarbonyl compound, which is widely distributed in food products and beverages, and is particularly high in Manuka honey.
Wang, Jiaying
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npj Science of Food, 2021 This study examined the effects of oral administration of water extract of chlorella (WEC) (100 mg/kg bodyweight) and phenethylamine (10 μg/kg bodyweight) on high-fat diet (HFD)-induced liver damage in mice.
Yifeng Zheng +5 more
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Methylglyoxal Uptake Coefficients on Aqueous Aerosol Surfaces [PDF]
, 2018 In order to predict the amount of secondary organic aerosol formed by heterogeneous processing of methylglyoxal, uptake coefficients (γ) and estimates of uptake reversibility are needed.
Pangui, Edouard +6 more
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Primary emissions of glyoxal and methylglyoxal from laboratory measurements of open biomass burning [PDF]
Atmospheric Chemistry and Physics, 2018 We report the emissions of glyoxal and methylglyoxal from the open burning of biomass during the NOAA-led 2016 FIREX intensive at the Fire Sciences Laboratory in Missoula, MT.
K. J. Zarzana +26 more
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Carbenium ion-mediated oligomerization of methylglyoxal for secondary organic aerosol formation
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Secondary organic aerosol (SOA) from photochemical oxidation of volatile organic compounds represents one of the most dominant constituents of fine particulate matter in the troposphere, with profound implications for air quality and climate.
Yue-Meng Ji +14 more
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