Results 41 to 50 of about 16,994 (228)

Markers of kidney injury, lipid metabolism, and carbonyl stress in patients with type 1 diabetes and different levels of albuminuria

Бюллетень сибирской медицины, 2022
The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods.
M. A. Darenskaya, E. V. Chugunova, S. I. Kolesnikov, L. A. Grebenkina, N. V. Semyonova, O. A. Nikitina, L. I. Kolesnikova   +6 more
doaj   +1 more source

Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension

Frontiers in Cardiovascular Medicine, 2022
BackgroundHeightened glycolytic flux is associated with right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH). Methylglyoxal, a glycolysis byproduct, is a highly reactive dicarbonyl that has toxic effects via non-enzymatic post ...
Sasha Z. Prisco, Lynn Hartweck, Jennifer L. Keen, Neal Vogel, Felipe Kazmirczak, Megan Eklund, Anna R. Hemnes, Evan L. Brittain, Kurt W. Prins   +8 more
doaj   +1 more source

The effect of methylglyoxal on the glycolytic enzymes [PDF]

FEBS Letters, 1980
with free arginine and have found that the reaction rate, much faster with methylglyoxal than with phenylglyoxal, depends on the buffer type and increases by increasing the pH. Data on the inactivation mechanism of aldolase and glyceraldehyde-3-phosphate dehydrogenase by methyl- glyoxal have shown that one arginine residue is involved in the ...
Leoncini, Giuliana, Maresca, Mitzi, Bonsignore, Arturo   +2 more
openaire   +2 more sources

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463)   +14 more
core   +1 more source

Engineered AuNPs/fMWCNT Nanocomposite Electrodes for High‐Sensitivity Methylglyoxal Sensing in Saliva and Sweat for Non‐Invasive Diabetes Monitoring

Advanced Healthcare Materials, EarlyView.
An AuNPs/fMWCNT nanocomposite‐modified screen‐printed carbon electrode was engineered via sequential electrodeposition and integrated into a 3D‐printed microfluidic platform for ultrasensitive methylglyoxal detection. The non‐invasive sensing platform enables rapid analysis in saliva and sweat, highlighting strong potential for wearable point‐of‐care ...
Ahadul Amin Soshi, Md Younus Ali, Dadbeh Pazuki, Matiar M.R. Howlader   +3 more
wiley   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan

, 2011
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Ricciardi, Filomena, Mack, Sandra J., Gispert, Suzana, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Strobel, Ingmar   +5 more
core   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

The Glyoxalase System—New Insights into an Ancient Metabolism

Antioxidants, 2020
The glyoxalase system was discovered over a hundred years ago and since then it has been claimed to provide the role of an indispensable enzyme system in order to protect cells from a toxic byproduct of glycolysis.
Jakob Morgenstern, Marta Campos Campos, Peter Nawroth, Thomas Fleming   +3 more
doaj   +1 more source

Investigation of Advanced Glycation End-Products, α-Dicarbonyl Compounds, and Their Correlations with Chemical Composition and Salt Levels in Commercial Fish Products

Foods, 2023
The contents of free and protein-bound advanced glycation end-products (AGEs) including Nε-carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL), along with glyoxal (GO), methylglyoxal (MGO), chemical components, and salt in commercially prepared and
Lihong Niu, Shanshan Kong, Fuyu Chu, Yiqun Huang, Keqiang Lai   +4 more
doaj   +1 more source

Role of methylglyoxal in essential hypertension [PDF]

International Journal of Angiology, 2010
Altered glucose metabolism due to insulin resistance is a common feature of essential hypertension in humans and in animal models. Elevated endogenous aldehydes in genetic (spontaneously hypertensive rats) and acquired (fructose-induced hypertensive rats) models of essential hypertension may be due to increased production of the reactive aldehyde ...
Sudesh, Vasdev, Jennifer, Stuckless
openaire   +2 more sources