Results 41 to 50 of about 18,817 (217)
EBioMedicineSummary: Background: We previously identified methylglyoxal as a biomarker for early identification and outcome prediction in human sepsis. We hypothesised that methylglyoxal causally impacts disease severity, and the methylglyoxal-scavenging dipeptide ...
Thomas Schmoch +12 more
doaj +1 more source
Бюллетень сибирской медицины, 2022 The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods.
M. A. Darenskaya +6 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundHeightened glycolytic flux is associated with right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH). Methylglyoxal, a glycolysis byproduct, is a highly reactive dicarbonyl that has toxic effects via non-enzymatic post ...
Sasha Z. Prisco +8 more
doaj +1 more source
The Impact of Glycation on Protein Digestibility
ChemFoodChem, EarlyView.Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann +2 more
wiley +1 more source
Role of methylglyoxal in essential hypertension [PDF]
International Journal of Angiology, 2010 Altered glucose metabolism due to insulin resistance is a common feature of essential hypertension in humans and in animal models. Elevated endogenous aldehydes in genetic (spontaneously hypertensive rats) and acquired (fructose-induced hypertensive rats) models of essential hypertension may be due to increased production of the reactive aldehyde ...
Sudesh, Vasdev, Jennifer, Stuckless
openaire +2 more sources
Seasonal in situ observations of glyoxal and methylglyoxal over the temperate oceans of the Southern Hemisphere [PDF]
Atmospheric Chemistry and Physics, 2015 The dicarbonyls glyoxal and methylglyoxal have been measured with 2,4-dinitrophenylhydrazine (2,4-DNPH) cartridges and high-performance liquid chromatography (HPLC), optimised for dicarbonyl detection, in clean marine air over the temperate Southern ...
S. J. Lawson +7 more
doaj +1 more source
Smart Molecules, EarlyView.BH‐PDN is a red‐emissive fluorescent probe that enables methylglyoxal (MGO) detection via a ring‐closure‐triggered turn‐on response. Probe‐based imaging uncovered prominent MGO buildup in Arabidopsis thaliana roots exposed to salinity, extreme temperatures and drought.
Yu‐Long Li +6 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.This work focuses on how to improve the selectivity and activity of electrocatalytic CO2 reduction to C3+ products, by the integration of electrocatalyst and electrolyte co‐design. We summarize key C3+ formation mechanisms and provide a comprehensive reaction network through thermodynamic analysis.
Ling Chen, Damien Voiry, Yan Jiao
wiley +2 more sources
The Glyoxalase System—New Insights into an Ancient Metabolism
Antioxidants, 2020 The glyoxalase system was discovered over a hundred years ago and since then it has been claimed to provide the role of an indispensable enzyme system in order to protect cells from a toxic byproduct of glycolysis.
Jakob Morgenstern +3 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source