Chemical insights, explicit chemistry, and yields of secondary organic aerosol from OH radical oxidation of methylglyoxal and glyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2013 Atmospherically abundant, volatile water-soluble organic compounds formed through gas-phase chemistry (e.g., glyoxal (C2), methylglyoxal (C3), and acetic acid) have great potential to form secondary organic aerosol (SOA) via aqueous chemistry in clouds ...
Y. B. Lim, Y. Tan, B. J. Turpin
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Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. [PDF]
PLoS ONE, 2013 The current epidemic of obesity and type 2 diabetes is attributed to a high carbohydrate diet, containing mainly high fructose corn syrup and sucrose. More than two thirds of diabetic patients have hypertension.
Indu Dhar +3 more
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Ferricytochrome (c) directly oxidizes aminoacetone to methylglyoxal, a catabolite accumulated in carbonyl stress. [PDF]
PLoS ONE, 2013 Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4 ...
Adriano Sartori +8 more
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Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]
, 2010 Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Rabbani, Naila +7 more
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Mechanisms leading to oligomers and SOA through aqueous photooxidation: insights from OH radical oxidation of acetic acid and methylglyoxal [PDF]
Atmospheric Chemistry and Physics, 2012 Previous experiments have demonstrated that the aqueous OH radical oxidation of methylglyoxal produces low volatility products including pyruvate, oxalate and oligomers.
Y. Tan +4 more
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The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
, 2014 The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
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Arginine-directed glycation and decreased HDL plasma concentration and functionality [PDF]
, 2014 Background/Objectives: Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased
Rabbani, Naila +4 more
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The role of the thiol group in protein modification with methylglyoxal [PDF]
Journal of the Serbian Chemical Society, 2009 Methylglyoxal is a highly reactive α-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction
Aćimović Jelena M. +2 more
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Integrated stress response of Escherichia coli to methylglyoxal : transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I [PDF]
, 2013 © 2013 The Authors.
Miller, Samantha +4 more
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The methylglyoxal pathway is a sink for glutathione in Salmonella experiencing oxidative stress.
PLoS Pathogens, 2023 Salmonella suffer the cytotoxicity of reactive oxygen species generated by the phagocyte NADPH oxidase in the innate host response. Periplasmic superoxide dismutases, catalases and hydroperoxidases detoxify superoxide and hydrogen peroxide (H2O2 ...
Sashi Kant +2 more
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