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Dual roles of methylglyoxal in cancer
Frontiers in OncologyCancer treatment currently includes a variety of approaches. Chemotherapy, targeted therapy, and immunotherapy are combined based on cancer characteristics to develop personalized treatment plans.
Zongao Wang +3 more
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Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease
Chemical Research in Toxicology, 2022 Metabolism is an essential part of life that provides energy for cell growth. During metabolic flux, reactive electrophiles are produced that covalently modify macromolecules, leading to detrimental cellular effects.
S. Lai +4 more
semanticscholar +1 more source
A quantification method for heat-decomposable methylglyoxal oligomers and its application on 1,3,5-trimethylbenzene SOA [PDF]
Atmospheric Chemistry and Physics, 2017 Methylglyoxal forms oligomeric compounds in the atmospheric aqueous particle phase, which could establish a significant contribution to the formation of aqueous secondary organic aerosol (aqSOA).
M. Rodigast, A. Mutzel, H. Herrmann
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Cell Death and Disease, 2022 Methylglyoxal (MGO) is an active metabolite of glucose and plays a prominent role in the pathogenesis of diabetic vascular complications, including endothelial cell apoptosis induced by oxidative stress.
G. Wang +8 more
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Trends in endocrinology and metabolism, 2022 Diabetes is associated with vascular injury and the onset of macrovascular complications. Advanced glycation endproducts (AGEs) and the AGE precursor methylglyoxal (MGO) have been identified as key players in establishing the relationship between ...
C. Schalkwijk, L. Micali, K. Wouters
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Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule
Molecules, 2022 Highlights● MGO may be essential for glycometabolism and bioenergetics in homeostasis and neural development;● MGO may be an essential molecule in the regulation of neural homeostasis (redox homeostasis, lipid metabolism homeostasis, energy homeostasis ...
Ze-Yong Yang +3 more
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Methylglyoxal Comes of AGE [PDF]
Cell, 2006 The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene ...
Ramasamy, Ravichandran +2 more
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Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen‐Glucose Deprivation [PDF]
Oxidative Medicine and Cellular Longevity, 2022 Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be elevated in hyperglycemic conditions.
Wei Chen +3 more
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Physiological Reviews, 2020 The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has been implicated in the pathogenesis of type 2 diabetes, vascular complications of diabetes, and several other age-related chronic inflammatory diseases such
C. Schalkwijk, C. Stehouwer
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Chemical insights, explicit chemistry, and yields of secondary organic aerosol from OH radical oxidation of methylglyoxal and glyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2013 Atmospherically abundant, volatile water-soluble organic compounds formed through gas-phase chemistry (e.g., glyoxal (C2), methylglyoxal (C3), and acetic acid) have great potential to form secondary organic aerosol (SOA) via aqueous chemistry in clouds ...
Y. B. Lim, Y. Tan, B. J. Turpin
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