Results 21 to 30 of about 18,817 (217)

Dual roles of methylglyoxal in cancer

Frontiers in Oncology
Cancer treatment currently includes a variety of approaches. Chemotherapy, targeted therapy, and immunotherapy are combined based on cancer characteristics to develop personalized treatment plans.
Zongao Wang, Shaojun Liu, Minghui Zhang, Min Liu   +3 more
doaj   +3 more sources

Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen‐Glucose Deprivation [PDF]

Oxidative Medicine and Cellular Longevity, 2022
Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be elevated in hyperglycemic conditions.
Wei Chen, Wenhui Huang, Yu Yang, Keshen Li   +3 more
openaire   +2 more sources

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]

, 2010
Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Rabbani, Naila, Santarius, Thomas, Larkin, Sarah J., Waris, Sahar, Fleming, Thomas, Thornalley, Paul J., Winklhofer-Roob, Brigitte M., Stratton, Michael R.   +7 more
core   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

, 2014
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

Arginine-directed glycation and decreased HDL plasma concentration and functionality [PDF]

, 2014
Background/Objectives: Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased
Rabbani, Naila, Smith, L., Godfrey, L. (Lisa), Thornalley, Paul J., Yamada-Fowler, N. (Naomi)   +4 more
core   +1 more source

Methylglyoxal Uptake Coefficients on Aqueous Aerosol Surfaces [PDF]

, 2018
In order to predict the amount of secondary organic aerosol formed by heterogeneous processing of methylglyoxal, uptake coefficients (γ) and estimates of uptake reversibility are needed.
Jean-François Doussin (2033350), David O. De Haan, Pangui, Edouard, Doussin, Jean-Francois, de Loera, Alexia, Alexia de Loera, Edouard Pangui, Natalie G. Jimenez, de Haan, David, Gratien, Aline, Cazaunau, Mathieu, Aline Gratien, Aline Gratien (2011024), Natalie G. Jimenez (4107985), Jimenez, Natalie, Jean-François Doussin, De Haan, David O., Mathieu Cazaunau, Jimenez, Natalie G., David O. De Haan (1306281), Alexia de Loera (4012562), Mathieu Cazaunau (1414612), Edouard Pangui (3482216)   +22 more
core   +2 more sources

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463)   +14 more
core   +1 more source

The role of the thiol group in protein modification with methylglyoxal [PDF]

Journal of the Serbian Chemical Society, 2009
Methylglyoxal is a highly reactive α-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction
Aćimović Jelena M., Stanimirović Bojana D., Mandić Ljuba M.   +2 more
doaj   +3 more sources

Integrated stress response of Escherichia coli to methylglyoxal : transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I [PDF]

, 2013
© 2013 The Authors.
Miller, Samantha, Booth, Ian R, de Moura, Alessandro P S, Ozyamak, Ertan, de Almeida, Camila   +4 more
core   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]

, 2011
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Ricciardi, Filomena, Mack, Sandra J., Gispert, Suzana, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Strobel, Ingmar   +5 more
core   +1 more source