Results 11 to 20 of about 18,817 (217)
Methylglyoxal, the dark side of glycolysis [PDF]
Frontiers in Neuroscience, 2015 Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic ...
Igor eAllaman +4 more
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Methylglyoxal Comes of AGE [PDF]
Cell, 2006 The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene ...
Ramasamy, Ravichandran +2 more
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Metilglioxal: uma toxina endógena? Is methylglyoxal an endogenous toxin? [PDF]
Química Nova, 2010 Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation.
Adriano Sartori +1 more
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Methylglyoxal alters C-fibre activity-dependent slowing and induces heat hyperalgesia in a sex-dependent manner, in rats [PDF]
PAIN Reports. Introduction:. Raised plasma levels of the glycolytic metabolite methylglyoxal are associated with pain symptoms in patients with diabetic neuropathy.
Atanaska N. Velichkova +3 more
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A new source of methylglyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2016 Carbonyl compounds are ubiquitous in atmospheric multiphase system participating in gas, particle, and aqueous-phase chemistry. One important compound is methyl ethyl ketone (MEK), as it is detected in significant amounts in the gas phase as well as ...
M. Rodigast +3 more
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Metformin-like Methylglyoxal Scavengers from Macroalgae Chondrus crispus and Gracilaria vermiculophyla Preserve Cell Viability [PDF]
Marine DrugsA quantitative NMR assay was utilized to identify methylglyoxal-scavenging natural products from Rhodophytes, Chondrus crispus and Gracilaria vermiculophylla.
George S. Hanna +5 more
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Role of Methylglyoxal in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer’s disease are extracellular aggregation of amyloidβpeptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein.
ANGELONI, CRISTINA +2 more
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Effect of methylglyoxal on multidrug-resistant Pseudomonas aeruginosa [PDF]
Frontiers in Microbiology, 2014 Honey has a complex chemistry, and its broad-spectrum antimicrobial activity varies with floral source, climate, and harvesting conditions. Methylglyoxal was identified as the dominant antibacterial component of manuka honey.
Katsuhiko eHayashi +3 more
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, 2014 Methylglyoxal (MG) is a reactive α-dicarbonyl, and may be the most important reactive aldehyde that is primarily generated endogenously in cells and exogenously due to autoxidation process. Interestingly, diabetes was the first disease in which evidence emerged for the increased formation of MG in the body.
Parmar, Mayur S, M.S. Parmar
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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
ASN Neuro, 2018 Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species
Ryan B. Griggs +4 more
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