Results 11 to 20 of about 16,994 (228)
Methylglyoxal Comes of AGE [PDF]
Cell, 2006 The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene ...
Ramasamy, Ravichandran +2 more
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Metilglioxal: uma toxina endógena? Is methylglyoxal an endogenous toxin? [PDF]
Química Nova, 2010 Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation.
Adriano Sartori +1 more
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A new source of methylglyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2016 Carbonyl compounds are ubiquitous in atmospheric multiphase system participating in gas, particle, and aqueous-phase chemistry. One important compound is methyl ethyl ketone (MEK), as it is detected in significant amounts in the gas phase as well as ...
M. Rodigast +3 more
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Effect of methylglyoxal on multidrug-resistant Pseudomonas aeruginosa
Frontiers in Microbiology, 2014 Honey has a complex chemistry, and its broad-spectrum antimicrobial activity varies with floral source, climate, and harvesting conditions. Methylglyoxal was identified as the dominant antibacterial component of manuka honey.
Katsuhiko eHayashi +3 more
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Role of Methylglyoxal in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer’s disease are extracellular aggregation of amyloidβpeptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein.
ANGELONI, CRISTINA +2 more
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, 2014 Methylglyoxal (MG) is a reactive α-dicarbonyl, and may be the most important reactive aldehyde that is primarily generated endogenously in cells and exogenously due to autoxidation process. Interestingly, diabetes was the first disease in which evidence emerged for the increased formation of MG in the body.
Parmar, Mayur S, M.S. Parmar
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Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
ASN Neuro, 2018 Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species
Ryan B. Griggs +4 more
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Seasonal in situ observations of glyoxal and methylglyoxal over the temperate oceans of the Southern Hemisphere [PDF]
Atmospheric Chemistry and Physics, 2015 The dicarbonyls glyoxal and methylglyoxal have been measured with 2,4-dinitrophenylhydrazine (2,4-DNPH) cartridges and high-performance liquid chromatography (HPLC), optimised for dicarbonyl detection, in clean marine air over the temperate Southern ...
S. J. Lawson +7 more
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Dual roles of methylglyoxal in cancer
Frontiers in OncologyCancer treatment currently includes a variety of approaches. Chemotherapy, targeted therapy, and immunotherapy are combined based on cancer characteristics to develop personalized treatment plans.
Zongao Wang +3 more
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Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen‐Glucose Deprivation [PDF]
Oxidative Medicine and Cellular Longevity, 2022 Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be elevated in hyperglycemic conditions.
Wei Chen +3 more
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