Dual roles of methylglyoxal in cancer
Frontiers in OncologyCancer treatment currently includes a variety of approaches. Chemotherapy, targeted therapy, and immunotherapy are combined based on cancer characteristics to develop personalized treatment plans.
Zongao Wang +3 more
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Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen‐Glucose Deprivation [PDF]
Oxidative Medicine and Cellular Longevity, 2022 Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be elevated in hyperglycemic conditions.
Wei Chen +3 more
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Chemical insights, explicit chemistry, and yields of secondary organic aerosol from OH radical oxidation of methylglyoxal and glyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2013 Atmospherically abundant, volatile water-soluble organic compounds formed through gas-phase chemistry (e.g., glyoxal (C2), methylglyoxal (C3), and acetic acid) have great potential to form secondary organic aerosol (SOA) via aqueous chemistry in clouds ...
Y. B. Lim, Y. Tan, B. J. Turpin
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Methylglyoxal Comes of AGE [PDF]
Cell, 2006 The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene ...
Ramasamy, Ravichandran +2 more
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Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. [PDF]
PLoS ONE, 2013 The current epidemic of obesity and type 2 diabetes is attributed to a high carbohydrate diet, containing mainly high fructose corn syrup and sucrose. More than two thirds of diabetic patients have hypertension.
Indu Dhar +3 more
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Ferricytochrome (c) directly oxidizes aminoacetone to methylglyoxal, a catabolite accumulated in carbonyl stress. [PDF]
PLoS ONE, 2013 Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4 ...
Adriano Sartori +8 more
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Role of Methylglyoxal in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer’s disease are extracellular aggregation of amyloidβpeptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein.
ANGELONI, CRISTINA +2 more
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Mechanisms leading to oligomers and SOA through aqueous photooxidation: insights from OH radical oxidation of acetic acid and methylglyoxal [PDF]
Atmospheric Chemistry and Physics, 2012 Previous experiments have demonstrated that the aqueous OH radical oxidation of methylglyoxal produces low volatility products including pyruvate, oxalate and oligomers.
Y. Tan +4 more
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Metilglioxal: uma toxina endógena? Is methylglyoxal an endogenous toxin?
Química Nova, 2010 Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation.
Adriano Sartori +1 more
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The role of the thiol group in protein modification with methylglyoxal [PDF]
Journal of the Serbian Chemical Society, 2009 Methylglyoxal is a highly reactive α-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction
Aćimović Jelena M. +2 more
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