Results 11 to 20 of about 28,399 (260)
Methylglyoxal, the dark side of glycolysis [PDF]
Frontiers in Neuroscience, 2015 Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity for glycolytic ...
Igor eAllaman +4 more
doaj +9 more sources
Resveratrol protects mouse oocytes from methylglyoxal-induced oxidative damage. [PDF]
PLoS ONE, 2013 Methylglyoxal, a reactive dicarbonyl compound, is mainly formed from glycolysis. Methylglyoxal can lead to the dysfunction of mitochondria, the depletion of cellular anti-oxidation enzymes and the formation of advanced glycation ends.
Yu Liu +10 more
doaj +2 more sources
A ketogenic diet prevents methylglyoxal-evoked nociception by scavenging methylglyoxal
Pain, 2022 Methylglyoxal is a reactive dicarbonyl byproduct of glycolysis implicated in a growing number of neuropathic pain conditions, including chemotherapy-induced peripheral neuropathy, diabetic peripheral neuropathy, and radiculopathy with lumbar disc ...
J. Enders +4 more
semanticscholar +3 more sources
Metilglioxal: uma toxina endógena? Is methylglyoxal an endogenous toxin? [PDF]
Química Nova, 2010 Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation.
Adriano Sartori +1 more
doaj +2 more sources
Role of Methylglyoxal in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease is the most common and lethal neurodegenerative disorder. The major hallmarks of Alzheimer’s disease are extracellular aggregation of amyloidβpeptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein.
ANGELONI, CRISTINA +2 more
core +6 more sources
Effect of methylglyoxal on multidrug-resistant Pseudomonas aeruginosa [PDF]
Frontiers in Microbiology, 2014 Honey has a complex chemistry, and its broad-spectrum antimicrobial activity varies with floral source, climate, and harvesting conditions. Methylglyoxal was identified as the dominant antibacterial component of manuka honey.
Katsuhiko eHayashi +3 more
doaj +2 more sources
Methylglyoxal induces systemic symptoms of irritable bowel syndrome. [PDF]
PLoS ONE, 2014 Patients with irritable bowel syndrome (IBS) show a wide range of symptoms including diarrhea, abdominal pain, changes in bowel habits, nausea, vomiting, headache, anxiety, depression and cognitive impairment.
Shuang Zhang +5 more
doaj +2 more sources
EBioMedicineSummary: Background: We previously identified methylglyoxal as a biomarker for early identification and outcome prediction in human sepsis. We hypothesised that methylglyoxal causally impacts disease severity, and the methylglyoxal-scavenging dipeptide ...
Thomas Schmoch +12 more
doaj +2 more sources
Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
ASN Neuro, 2018 Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive carbonyl species
Ryan B. Griggs +4 more
doaj +2 more sources
Unveiling the interplay between methylglyoxal and plant growth under abiotic adversity via a red-emissive probe operated by a ring-closure mechanism. [PDF]
Smart MolBH‐PDN is a red‐emissive fluorescent probe that enables methylglyoxal (MGO) detection via a ring‐closure‐triggered turn‐on response. Probe‐based imaging uncovered prominent MGO buildup in Arabidopsis thaliana roots exposed to salinity, extreme temperatures and drought.
Li YL +6 more
europepmc +2 more sources