Results 31 to 40 of about 16,994 (228)

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]

, 2014
The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila, Brownlee, M., Geoffrion, M., Courville, K., Du, X., Irshad, Zehra, Vanderhyden, B. C., Ott-Braschi, S., Sui, G., Thornalley, Paul J., Milne, R. W., D'Agati, V. D.   +11 more
core   +1 more source

Rapid and Reliable HPLC Method for the Simultaneous Determination of Dihydroxyacetone, Methylglyoxal and 5-Hydroxymethylfurfural in Leptospermum Honeys. [PDF]

PLoS ONE, 2016
A reliable determination of dihydroxyacetone, methylglyoxal and 5-hydroxymethylfurfural is essential to establishing the commercial value and antimicrobial potential of honeys derived from the Leptospermum species endemic to Australia and New Zealand. We
Matthew Pappalardo, Linda Pappalardo, Peter Brooks   +2 more
doaj   +1 more source

Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells [PDF]

, 2016
Background and Objectives: Methylglyoxal is a toxic product derived from glucose metabolism that plays a role in inflammation, diabetes and aging. In addition, the periodontal pathogen Tannerella forsythensis may also generate this compound. However, the
González Rivas, C., Arancibia, R., Arancibia, M., Smith, P. C., Cáceres, M., Martínez, Jessica, Hernández, R., Romero, A., Martínez, J., Retamal, I., Romero, Antonia, Retamal, I. N., Cáceres Lluch, Mónica, González-Rivas, C., Tobar, N., Martínez, Constanza, Martínez, C., Tobar, Nicolás   +17 more
core   +1 more source

Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation

Frontiers in Neuroscience, 2017
Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor ...
Ryan B. Griggs, Don E. Laird, Renee R. Donahue, Renee R. Donahue, Weisi Fu, Bradley K. Taylor, Bradley K. Taylor, Bradley K. Taylor   +7 more
doaj   +1 more source

Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal

npj Science of Food, 2021
This study examined the effects of oral administration of water extract of chlorella (WEC) (100 mg/kg bodyweight) and phenethylamine (10 μg/kg bodyweight) on high-fat diet (HFD)-induced liver damage in mice.
Yifeng Zheng, Agustin Martin-Morales, Jing Wang, Masaki Fujishima, Eri Okumura, Kenji Sato   +5 more
doaj   +1 more source

Primary emissions of glyoxal and methylglyoxal from laboratory measurements of open biomass burning [PDF]

Atmospheric Chemistry and Physics, 2018
We report the emissions of glyoxal and methylglyoxal from the open burning of biomass during the NOAA-led 2016 FIREX intensive at the Fire Sciences Laboratory in Missoula, MT.
K. J. Zarzana, K. J. Zarzana, K. J. Zarzana, V. Selimovic, A. R. Koss, A. R. Koss, A. R. Koss, A. R. Koss, K. Sekimoto, K. Sekimoto, K. Sekimoto, M. M. Coggon, M. M. Coggon, B. Yuan, B. Yuan, B. Yuan, W. P. Dubé, W. P. Dubé, R. J. Yokelson, C. Warneke, C. Warneke, J. A. de Gouw, J. A. de Gouw, J. A. de Gouw, J. M. Roberts, S. S. Brown, S. S. Brown   +26 more
doaj   +1 more source

The effect of dicarbonyl stress on the development of kidney dysfunction in metabolic syndrome – a transcriptomic and proteomic approach

Nutrition & Metabolism, 2019
Background and aims Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfunction. In renal cells, toxic
Irena Markova, Martina Hüttl, Olena Oliyarnyk, Tereza Kacerova, Martin Haluzik, Petr Kacer, Ondrej Seda, Hana Malinska   +7 more
doaj   +1 more source

Quantification of Methylglyoxal Levels in Cowpea Leaves in Response to Cowpea Aphid Infestation

Bio-Protocol, 2020
Aphids are a serious pest of crops across the world. Aphids feed by inserting their flexible hypodermal needlelike mouthparts, or stylets, into their host plant tissues.
Jacob MacWilliams, Monika Ostaszewska-Bugajska, Klaudia Borysiuk, Bożena Szal, Isgouhi Kaloshian   +4 more
doaj   +1 more source

The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic β Cells by Regulating MafA Expression

Frontiers in Endocrinology, 2022
Methylglyoxal, a major precursor of advanced glycation end products, is elevated in the plasma of patients with type 2 diabetes mellitus. Islet β-cell function was recently shown to be regulated by N6-methyladenosine (m6A), an RNA modification consisting
Yi Cheng, Xin-Ming Yao, Si-Min Zhou, Yue Sun, Xiang-Jian Meng, Yong Wang, Yu-Jie Xing, Yu-Jie Xing, Shu-Jun Wan, Shu-Jun Wan, Shu-Jun Wan, Qiang Hua, Qiang Hua   +12 more
doaj   +1 more source

Anserine reduces mortality in experimental sepsis by preventing methylglyoxal-induced capillary leakageResearch in context

EBioMedicine
Summary: Background: We previously identified methylglyoxal as a biomarker for early identification and outcome prediction in human sepsis. We hypothesised that methylglyoxal causally impacts disease severity, and the methylglyoxal-scavenging dipeptide ...
Thomas Schmoch, Nadia Gallenstein, Verena Peters, Maria Bartosova, Florian Uhle, Laura Kummer, Anian Mair, Ute Krauser, Manuel Feisst, Peter P. Nawroth, Markus A. Weigand, Claus Peter Schmitt, Thorsten Brenner   +12 more
doaj   +1 more source