Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. [PDF]
PLoS ONE, 2013 The current epidemic of obesity and type 2 diabetes is attributed to a high carbohydrate diet, containing mainly high fructose corn syrup and sucrose. More than two thirds of diabetic patients have hypertension.
Indu Dhar +3 more
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Ferricytochrome (c) directly oxidizes aminoacetone to methylglyoxal, a catabolite accumulated in carbonyl stress. [PDF]
PLoS ONE, 2013 Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4 ...
Adriano Sartori +8 more
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International Journal of Environmental Research and Public Health, 2021 Up to 95% of the liquid volume in an e-cigarette consists of propylene glycol. Previous research has shown that propylene glycol can generate diacetyl and formaldehyde when heated. New research shows that propylene glycol can also generate methylglyoxal,
P. Azimi +6 more
semanticscholar +1 more source
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]
, 2010 Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Rabbani, Naila +7 more
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Mechanisms leading to oligomers and SOA through aqueous photooxidation: insights from OH radical oxidation of acetic acid and methylglyoxal [PDF]
Atmospheric Chemistry and Physics, 2012 Previous experiments have demonstrated that the aqueous OH radical oxidation of methylglyoxal produces low volatility products including pyruvate, oxalate and oligomers.
Y. Tan +4 more
doaj +1 more source
Arginine-directed glycation and decreased HDL plasma concentration and functionality [PDF]
, 2014 Background/Objectives: Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased
Rabbani, Naila +4 more
core +1 more source
The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
, 2014 The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
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Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation
Antioxidants, 2020 Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence of nutrient catabolism. The balance between ROS production and elimination allows to maintain cell redox homeostasis and biological functions, avoiding the occurrence
L. de Bari +5 more
semanticscholar +1 more source
Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]
, 2011 The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Ricciardi, Filomena +5 more
core +1 more source
A new source of methylglyoxal in the aqueous phase [PDF]
Atmospheric Chemistry and Physics, 2016 Carbonyl compounds are ubiquitous in atmospheric multiphase system participating in gas, particle, and aqueous-phase chemistry. One important compound is methyl ethyl ketone (MEK), as it is detected in significant amounts in the gas phase as well as ...
M. Rodigast +3 more
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