Results 51 to 60 of about 12,428 (180)

Non‐Enzymatic Browning Under Emerging Cooking Technologies: Matrix‐Dependent Pathways, Neoformed Compounds, and Nutritional–Toxicological Trade‐Offs

eFood, Volume 7, Issue 4, August 2026.
Non‐enzymatic browning in foods is a dynamic reaction network integrating Maillard chemistry, caramelization, lipid oxidation, and ascorbic acid degradation. Processing technologies and matrix factors govern pathways, balancing desirable sensory attributes with harmful compounds.
Djilali Benabdelmoumene, Said Dahmouni, Muhammad Waqar, Zineb Bengharbi, Mustapha Kamel Fodil, Noureddine Benguennouna, Wasim S. M. Qadi, Ahmed Mediani   +7 more
wiley   +1 more source

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSEEndothelial dysfunction is a feature of hypertension and diabetes. Methylglyoxal (MG) is a reactive dicarbonyl metabolite of glucose and its levels are elevated in spontaneously hypertensive rats and in diabetic patients. We investigated if MG induces endothelial dysfunction and whether MG scavengers can prevent endothelial ...
Arti, Dhar, Indu, Dhar, Kaushik M, Desai, Lingyun, Wu   +3 more
openaire   +2 more sources

Antiglycation of Insulin by Selected Six Bioactive Peanut Sprout Stilbenoids and Demonstration of Methylglyoxal‐Mediated Biphasic Insulin Glycation by O‐Phenylenediamine Derivatization

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Graphical abstract demonstrates 6 peanut sprout containing stilbenoids exhibiting varied structure‐activity potency in protection of insulin integrity from glycation mediated by methylglyoxal (MG), glucose and fructose. Meanwhile, MG‐mediated biphasic insulin glycation was evidenced in Tricine SDS‐PAGE analysis and supported by O‐phenylenediamine (OPD)
Po‐Chang Chiu, Shu‐Mei Lin, Yu‐Jang Li, Chih‐Yu Lo, Robin Y.‐Y. Chiou   +4 more
wiley   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Methylglyoxal Binding to Bovine Liver Catalase Results in Loss of Activity and Heme Dislocation

Trends in Peptide and Protein Sciences, 2019
Glycation, the non-enzymatic attachment of glucose to protein, is one of the important events in the pathophysiology of diabetes mellitus, Alzheimer’s, Parkinson’s and other diseases.
Subramanian Sivakami, Sejal A Shah, George Suji, Vikrant M Bhor, Ahmad Ali   +4 more
doaj   +1 more source

4‐1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions

Immunology &Cell Biology, Volume 104, Issue 7, Page 686-699, August 2026.
4‐1BB is a highly expressed TNFRSF co‐stimulatory receptor on MAIT cells upon activation. Expression and signaling via 4‐1BB enhance activation and provide co‐stimulation, boosting MAIT cell effector responses to TCR‐mediated activation. ABSTRACT Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that recognize microbe ...
Lamichhane R, Williams J, Tirand C, Fouillé R, Wedlock LE, Poudel A, Webley MC, Hannaway RF, Ussher JE   +8 more
wiley   +1 more source

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

Optimizing enzyme properties to enhance dihydroxyacetone production via methylglyoxal biosensor development

Microbial Cell Factories
Background Dihydroxyacetone (DHA) stands as a crucial chemical material extensively utilized in the cosmetics industry. DHA production through the dephosphorylation of dihydroxyacetone phosphate, an intermediate product of the glycolysis pathway in ...
Kaibo Zhang, Mengying Li, Jinsheng Wang, Guozhong Huang, Kang Ma, Jiani Peng, Haoyue Lin, Chunjie Zhang, Honglei Wang, Tao Zhan, Zhe Sun, Xueli Zhang   +11 more
doaj   +1 more source