Results 51 to 60 of about 28,399 (260)

The effect of dicarbonyl stress on the development of kidney dysfunction in metabolic syndrome – a transcriptomic and proteomic approach

Nutrition & Metabolism, 2019
Background and aims Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfunction. In renal cells, toxic
Irena Markova, Martina Hüttl, Olena Oliyarnyk, Tereza Kacerova, Martin Haluzik, Petr Kacer, Ondrej Seda, Hana Malinska   +7 more
doaj   +1 more source

Quantification of Methylglyoxal Levels in Cowpea Leaves in Response to Cowpea Aphid Infestation

Bio-Protocol, 2020
Aphids are a serious pest of crops across the world. Aphids feed by inserting their flexible hypodermal needlelike mouthparts, or stylets, into their host plant tissues.
Jacob MacWilliams, Monika Ostaszewska-Bugajska, Klaudia Borysiuk, Bożena Szal, Isgouhi Kaloshian   +4 more
doaj   +1 more source

Methylglyoxal Formation—Metabolic Routes and Consequences

Antioxidants
Methylglyoxal (MGO), a by-product of glycolysis, plays a significant role in cellular metabolism, particularly under stress conditions. However, MGO is a potent glycotoxin, and its accumulation has been linked to the development of several pathological ...
J. Vašková, Gabriela Kováčová, Jakub Pudelský, Drahomír Palenčár, Helena Mičková   +4 more
semanticscholar   +1 more source

Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity [PDF]

, 2015
Glycation, an endogenous process that leads to the production of advanced glycation end products (AGEs), plays a role in the etiopathogenesis of different neurodegenerative diseases, such as Alzheimer's disease (AD).
ANGELONI, Cristina, Malaguti, Marco, Barbalace, Maria Cristina, Hrelia, Silvana, Rizzo, Benedetta, Fabbri, Daniele   +5 more
core   +1 more source

Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?

Biomedicines
Methylglyoxal (MGO) is a highly reactive α-dicarbonyl compound formed endogenously from 3-carbon glycolytic intermediates. Methylglyoxal accumulated in plasma and urine of hyperglycemic and diabetic individuals acts as a potent peptide glycation molecule,
A. L. Oliveira, M. G. de Oliveira, F. Mónica, Edson Antunes   +3 more
semanticscholar   +1 more source

Markers of kidney injury, lipid metabolism, and carbonyl stress in patients with type 1 diabetes and different levels of albuminuria

Бюллетень сибирской медицины, 2022
The aim of this work was to study the levels of podocalyxin and β-2-microglobulin and parameters of lipid metabolism and carbonyl stress in type 1 diabetes mellitus (T1DM) patients with different levels of albuminuria.Materials and methods.
M. A. Darenskaya, E. V. Chugunova, S. I. Kolesnikov, L. A. Grebenkina, N. V. Semyonova, O. A. Nikitina, L. I. Kolesnikova   +6 more
doaj   +1 more source

Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension

Frontiers in Cardiovascular Medicine, 2022
BackgroundHeightened glycolytic flux is associated with right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH). Methylglyoxal, a glycolysis byproduct, is a highly reactive dicarbonyl that has toxic effects via non-enzymatic post ...
Sasha Z. Prisco, Lynn Hartweck, Jennifer L. Keen, Neal Vogel, Felipe Kazmirczak, Megan Eklund, Anna R. Hemnes, Evan L. Brittain, Kurt W. Prins   +8 more
doaj   +1 more source

Methylglyoxal interaction with superoxide dismutase 1

Redox Biology, 2020
Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-product of glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced glycation end-products (AGEs). MG binds to
P. Polykretis, E. Luchinat, F. Boscaro, L. Banci   +3 more
semanticscholar   +1 more source

Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chromatin comprises the approximately 3 billion bases in the human genome and histone proteins. Histone posttranslational modifications (PTMs) regulate chromatin dynamics and protein transcription to expand the genetic code.
J. Galligan, James A. Wepy, Matthew D. Streeter, Philip J. Kingsley, M. M. Mitchener, Orrette R Wauchope, William N. Beavers, Kristie L. Rose, Tina Wang, D. Spiegel, L. Marnett   +10 more
semanticscholar   +1 more source

Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Nature Communications, 2020
Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain.
D. C. Rodrigues, Emily M. Harvey, Rejitha Suraj, Sarah L. Erickson, Lamees Mohammad, Meng-Li Ren, Hongrui Liu, G. He, D. Kaplan, J. Ellis, Guang Yang   +10 more
semanticscholar   +1 more source