Results 91 to 100 of about 16,994 (228)

Trapping of methylglyoxal by dietary compounds in vitro

, 2007
The importance of reactive dicarbonyl speices has been raising because of its link to many health complications. Diabetes, with the high prevalence and continued investigation on its link to methylglyoxal interested us to initiate this study.

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Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease

, 2019
Purpose of reviewChronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments.
Schalkwijk, Casper G.; id_orcid, Hanssen, Nordin M. J., Schalkwijk, Casper G., Stehouwer, Coen D. A.; id_orcid, Stehouwer, Coen D. A.   +4 more
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Methylglyoxal metabolism in trypanosomes and leishmania

Seminars in Cell & Developmental Biology, 2011
Methylglyoxal is a toxic by-product of glycolysis and other metabolic pathways. In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6).
Wyllie, Susan, Fairlamb, Alan H.
openaire   +3 more sources

Association Between the Cholesterol–HDL–Glucose (CHG) Index and 90‐Day Functional Outcomes in Patients with Acute Ischemic Stroke

Brain and Behavior, Volume 16, Issue 6, June 2026.
The CHG index, derived from total cholesterol, high‐density lipoprotein, and fasting blood glucose, was associated with 90‐day functional outcomes after acute ischemic stroke. ABSTRACT Background: Acute ischemic stroke (AIS) is a major cause of global disability and mortality.
Xinyue Yuan, Xiangqi Kong, Mina Zhao, Penghong Li, Haobo Wang, Wei Jing   +5 more
wiley   +1 more source

Determination of toxic α-dicarbonyl compounds in sesame oils using dispersive liquid–liquid microextraction coupled with gas chromatography–mass spectrometry

Food Chemistry: X
Glyoxal, methylglyoxal, and diacetyl are toxic α-dicarbonyl compounds found in heat-processed foods, including edible oils. Dispersive liquid–liquid microextraction was combined with gas chromatography mass spectrometry to determine the glyoxal ...
Jangho Lee, Tae Gyu Nam, Hyo-Kyoung Choi, Hae Won Jang   +3 more
doaj   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Assay of methylglyoxal and glyoxal and control of peroxidase interference

, 2014
Methylglyoxal and glyoxal are endogenous α-oxoaldehyde metabolites and substrates of the glyoxalase system. These and related α-oxoaldehydes are often determined in cell, tissue and body fluid samples by derivatization with 1,2-diaminobenzene and similar
Rabbani, Naila, Thornalley, Paul J.
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Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

Molecules, 2014
The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to
Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz   +2 more
doaj   +1 more source

Morphological and Biochemical Insights Into the Renoprotective Effects of Combined N‐Acetylcysteine and Glycine Treatment in Experimental Diabetic Nephropathy

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus and the leading cause of end‐stage renal disease. Oxidative stress and inflammation are central drivers of DN progression, yet no effective therapies exist to prevent or delay renal injury. This study investigated the renoprotective effects of glycine (GLY), N‐
Malik Ejubović, Andrej Belančić, Yun Wah Lam, Farideh Javid, Dina Kapić, Esad Ćosović, Rijad Jahić, Orhan Lepara, Amira Jagodić Ejubović, Lejla Alić, Amil Topuz, Zurifa Ajanović, Almir Fajkić   +12 more
wiley   +1 more source

Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents [PDF]

Methylglyoxal is a highly reactive metabolite that is formed spontaneously in the glycolytic pathway. The side chains of various amino acid residues react with methylglyoxal to form advanced-glycation end products (AGEs).
Hermans, Jos H, Horvatovich, Peter L; id_orcid, Witte, Martin D; id_orcid, Witte, Martin D, Sardaru, I Raluca, Sokoliova, Saskia, Warguła, Franciszek P, Permentier, Hjalmar P; id_orcid   +7 more
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