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Benefits, deleterious effects and mitigation of methylglyoxal in foods: A critical review

open access: yes, 2020
Background Methylglyoxal, a reactive carbonyl compound widely present in thermally processed foods, is produced from sugar degradation and lipid oxidation.
Jie Zheng   +11 more
semanticscholar   +2 more sources
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Methylglyoxal

Plant Signaling Molecules, 2019
Due to high reactivity of methylglyoxal (MG) with biomacromolecules, it has been previously regarded to be a cytotoxin. Recently, MG is emerging as a signaling molecule, which regulates seed germination, plant growth, development, reproduction, and ...
Zhong-Guang Li
semanticscholar   +2 more sources

Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease

open access: yesCurrent opinion in nephrology and hypertension, 2019
Purpose of review Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments.
N. Hanssen, C. Stehouwer, C. Schalkwijk
semanticscholar   +2 more sources

Mechanism of Carbon Skeleton Formation of 2,3,5-Trimethylpyrazine via a Conversion Reaction between Methylglyoxal and Glyoxal.

Journal of Agricultural and Food Chemistry, 2023
Maillard flavor compounds, such as 2,3,5-trimethylpyrazine, have been frequently identified in thermally processed food products, such as popcorn and peanuts.
Wei-Qun Jiang   +5 more
semanticscholar   +1 more source

High-Resolution Mass Spectrometry Analysis of Melanoidins and Their Precursors Formed in a Model Study of the Maillard Reaction of Methylglyoxal with l-Alanine or l-Lysine.

Journal of Agricultural and Food Chemistry, 2021
Despite more than 100 years of research, formation of food melanoidins from carbohydrates and amino acids in the course of the Maillard reaction is still not fully understood.
Clemens Kanzler, Felix Wustrack, S. Rohn
semanticscholar   +1 more source

Methylglyoxal toxicity in mammals

Toxicology Letters, 1994
Although the interest is growing towards glyoxalases and methylglyoxal, their role in metabolism is still an enigma. In this paper, the effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules (nucleic acids, proteins).
Miklós Peter Kalapos
exaly   +3 more sources

Methylglyoxal, obesity, and diabetes

Endocrine, 2012
Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose metabolism. This metabolite has been implicated in diabetic complications as it is a strong AGE precursor. Furthermore, recent studies suggested a role for MG in insulin resistance and beta-cell dysfunction. Although several drugs have been developed in the recent
Paulo, Matafome   +2 more
openaire   +2 more sources

A fluorogenic assay for methylglyoxal

Biochemical Society Transactions, 2014
MG (methylglyoxal) is a potent glycating agent and an endogenous reactive dicarbonyl metabolite formed in all live cells and organisms. It is an important precursor of AGEs (advanced glycation end-products) and is implicated in aging and disease. MG is assayed by derivatization by 1,2-diaminobenzene derivatives in cell extracts.
Fozia, Shaheen   +3 more
openaire   +2 more sources

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