Results 201 to 210 of about 28,399 (260)
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The effect of methylglyoxal on actin
Biochemical and Biophysical Research Communications, 1981Abstract Studying the gelation of Ehrlich ascites tumor cell extracts at various methyglyoxal concentrations, an increase of the gelled protein fraction, composed mainly of actin, was found at 10 −7 M to 10 −5 M. When methylglyoxal was added to intact tumor cells, the filamentous portion of cytoplasmic actin was increased at 10 −7 M to 10 −6 M ...
Fesus, L, Muszbek, L, Laki, K
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Trapping Methylglyoxal by Myricetin and its Metabolites in Mice.
Journal of Agricultural and Food Chemistry, 2020Trapping of methylglyoxal (MGO) has been determined to be one of the potential mechanisms for dietary polyphenols to prevent chronic diseases. In this study, myricetin was demonstrated to efficiently trap MGO to generate mono- and di-MGO adducts under in
Shu-Wei Zhang +3 more
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Journal of Hazardous Materials, 2020
We investigated the mechanistic consequences of selenium (Se)-toxicity, and its possible mitigation using salicylic acid (SA) in rice. In comparison with control, sodium selenate-exposed 'Se1' (0.5 mM) and 'Se2' (1.0 mM) plants showed accumulation of Se ...
M. G. Mostofa +4 more
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We investigated the mechanistic consequences of selenium (Se)-toxicity, and its possible mitigation using salicylic acid (SA) in rice. In comparison with control, sodium selenate-exposed 'Se1' (0.5 mM) and 'Se2' (1.0 mM) plants showed accumulation of Se ...
M. G. Mostofa +4 more
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Methylglyoxal and cell viability
International Journal of Biochemistry, 1994Methylglyoxal by depleting glutathione stores increased Trypan-blue uptake by the cells incubated in glucose, pyruvate and amino acids free medium. Only a transient fall of glutathione concentration without any effect on cell viability was caused by methylglyoxal when the medium was supplemented with above-mentioned compounds.
L, Braun +4 more
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Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation.
Trends in endocrinology and metabolism, 2019Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes.
Rasmus Kold-Christensen, M. Johannsen
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Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.
Diabetes Research and Clinical Practice, 2019Diabetes is one of the most frequent diseases throughout the world and its incidence is predicted to exponentially progress in the future. This metabolic disorder is associated with major complications such as neuropathy, retinopathy, atherosclerosis ...
J. Bellier +6 more
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Archives of Biochemistry and Biophysics, 1977
Abstract [ 14 C]Dihydroxyacetone phosphate labeled in either the C-1 or C-3 position was enzymatically synthesized, isolated, and utilized as a substrate for crystalline methylglyoxal synthase purified from Proteus vulgaris . After reaction with the enzyme, the methyl carbon of methylglyoxal 3 was identified as CHI 3 by the iodoform reaction ...
P M, Yuan, R W, Gracy
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Abstract [ 14 C]Dihydroxyacetone phosphate labeled in either the C-1 or C-3 position was enzymatically synthesized, isolated, and utilized as a substrate for crystalline methylglyoxal synthase purified from Proteus vulgaris . After reaction with the enzyme, the methyl carbon of methylglyoxal 3 was identified as CHI 3 by the iodoform reaction ...
P M, Yuan, R W, Gracy
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METABOLISM OF METHYLGLYOXAL IN MICROORGANISMS
Annual Review of Microbiology, 1984INTRODUCTION 49 A METHYl.GLYOXAL BYPASS OF THE EMBDEN·MEYERHOF PATHWAy...... 51 CYTOTOXIC NATURE OF METHYLGLYOXAL ........ 54 ENZYMA TJ[C FORMATION OF METHYLGLYOXAL 54 Studies on Methylglyoxal Synthase 54 Glyceraldehyde 3.Phosphate and Glyceraldehyde as Possible Precursors of Methylglyoxal 57 Acetol Dehydrogenase 57 Methylglyoxal from ...
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Glycerol and Methylglyoxal Metabolism
EcoSal Plus, 2005The metabolic connection between glycerol and methylglyoxal (MG) is principally that DHAP, which is an intermediate in the aerobic breakdown of glycerol, is also the major precursor of MG, being the substrate for methylglyoxal synthase (MGS).
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Methylglyoxal Bis(guanylhydrazone) Analogs VI. Methylglyoxal Bis(guanylhydrazone) Pamoate
Journal of Pharmaceutical Sciences, 1968The pamoate of methylglyoxal bis(guanylhydrazone) was prepared. This compound, on a molar basis, is more active and less toxic than the corresponding dihydrochloride salt against leukemia L-1210.
E G, Podrebarac, C C, Cheng
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