Results 131 to 140 of about 37,526 (188)

Aplastic anaemia: From genetic susceptibility to epigenetic dysregulation

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Junchen Lai, Xinan Wang
wiley   +1 more source

Using ngTALEN to improve genome editing efficiency on targets containing 5‐methylcytosines

The Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY We recently discovered distinct methylation patterns between the mitochondrial genome and the nuclear‐encoded mitochondrial DNA sequences (NUMTs), with the mitochondrial genome being hypomethylated and NUMTs being hypermethylated. Given that genome editing using mitochondrial targeted transcription activator‐like effector nucleases (TALEN) is ...
Zhicai Wang, Yoshiko Tamura, Masaru Hashimoto, Issei Nakazato, Asuka Yamaguchi‐Nishimura, Shin‐ichi Arimura   +5 more
wiley   +1 more source

How epigenetic evolution can guide genetic evolution (abstract)

, 2008
The expression level of a gene in future generations can be modified both by genetic mutations and by the attachment of methyl groups to the DNA. Since the DNA methylation pattern along a genome is inherited, methylation patterns constitute a significant
Groom, Graeme, Mills, Rob, Watson, Richard A.   +2 more
core  

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

Mepylome: A Point‐of‐Care Tumor Diagnostic Toolkit for Tumor DNA Methylation and Copy Number Analysis

Advanced Intelligent Systems
DNA methylation and copy number variation (CNV) profiling are essential for diagnostic tumor classification. Current methods are complex and require considerable bioinformatics expertise, limiting clinical implementation.
Jon Brugger, Claus Hultschig, Daniel Baumhoer, Baptiste Ameline, Benjamin Maciej Freyter, Stephan Frank, Jürgen Hench   +6 more
doaj   +1 more source

A systematic review of methylome-wide associations with anxiety disorders. [PDF]

Transl Psychiatry
Ingram SJ, Zillich L, Schiele MA, Psychiatric Genomics Consortium Anxiety Epigenetics Workgroup, Domschke K, Hettema JM, Clark SL.   +6 more
europepmc   +1 more source

Layering Methylome and Transcriptome in the Same Tissue Slice. [PDF]

Genomics Proteomics Bioinformatics
Xiao Y, Ma S.
europepmc   +1 more source

Erratum: Expanded methylome and quantitative trait loci detection by long-read profiling of personal DNA. [PDF]

Genome Res
Groza C, Ge B, Cheung WA, Pastinen T, Bourque G.   +4 more
europepmc   +1 more source

Parental kinship influences global methylation and epigenetic age estimation in Peromyscus. [PDF]

Genetics
Huynh-Dam KT, Jaeger C, Chatzistamou I, Horvath S, Kiaris H.   +4 more
europepmc   +1 more source

Ultra-mild bisulphite sequencing for DNA methylation analysis from low-input clinical specimens. [PDF]

Clin Epigenetics
Zaki RA, Khurana I, El-Osta A.
europepmc   +1 more source