Results 131 to 140 of about 26,277 (245)

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, Volume 13, Issue 51, 14 September 2026.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

DNA Methylation and Transcriptome Profiling Reveal the Role of the Antioxidant Pathway and Lipid Metabolism in Plectropomus leopardus Skin Color Formation

Antioxidants
Leopard coral grouper (Plectropomus leopardus), possessing a distinct red body color, is an important species in commercial markets; however, the high ratio of black individuals under intensive cultivation has limited the commercial value of the species.
Yang Liu, Linna Wang, Zhentong Li, Linlin Li, Tangtang Ding, Shuai Chen, Pengfei Duan, Xinyi Wang, Yishu Qiu, Xiaoyu Ding, Yongsheng Tian   +10 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

Groundnut Improvement for Aflatoxin Resistance: Progress and Opportunities

Food and Energy Security, Volume 15, Issue 5, September/October 2026.
ABSTRACT Groundnut, or peanut, is an industrial oilseed crop that serves the food and feed industries and provides income along the value chain. Pre‐ and post‐harvest aflatoxin contamination, caused by Aspergillus spp., hinders the food and feed value and market opportunities of groundnut products. Developing and deploying aflatoxin‐resistant varieties
Tullu Tadessa Asefa, Hussein Shimelis, Janila Pasupuleti, Seltene Abady Tesfamariam   +3 more
wiley   +1 more source

Modification of the RNA methylome in neurodevelopmental disorders [PDF]

RNA metabolism is fundamental to protein synthesis, degradation and transport of molecules. Methylation of RNA influences the processing of mRNA, noncoding RNA, tRNA and rRNA.
Orji, Oliver C., PerezGrovas-Saltijeral, Adriana, Shaker, Hala, Knight, Helen M., Stones, Joseph   +4 more
core   +1 more source

Molecular Mechanisms and Regulation of Anthocyanin Biosynthesis in Rosaceae Fruits: A Review

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Five‐tiered regulatory network governing anthocyanin biosynthesis in Rosaceae fruits, integrating environmental signals, epigenetic/transcriptional control, flavonoid metabolism, pigment trafficking and breeding translation. This review elaborates layered regulatory networks underlying anthocyanin production in core Rosaceae crops (Malus, Pyrus ...
Menghua Luo, Wanjia Tang, Xiaoqing Yuan, Can Hu   +3 more
wiley   +1 more source

Chromosome‐level genome and methylome of vine tea suggest roles for tandem duplication and CHH hypomethylation in high dihydromyricetin accumulation

iMetaOmics, Volume 3, Issue 3, September 2026.
A chromosome‐level genome assembly and single‐base resolution methylome of vine tea (Nekemias grossedentata) reveal that lineage‐specific tandem duplications of dihydromyricetin (DHM) biosynthetic genes (NgCHS and NgF3′5′ H) have expanded their copy numbers, providing the genetic basis for high DHM flux.
Yingmei Wu, Hanrui Hu, Qing Ye, Xueqing Chen, Miyuan Tian, Jing Li, Li Lu, Yifei Liu, Yi Shang, Yanling Li, Xingyao Xiong, Junbo Gou   +11 more
wiley   +1 more source

Nitrogen‐Starved Wheat: A Multi‐Omics Perspective From Epigenome Regulation to Grain Quality

Journal of Sustainable Agriculture and Environment, Volume 5, Issue 3, September 2026.
This review establishes epigenetic regulation, specifically H3K27ac and H3K27me3 dynamics at nitrogen transporter, assimilation, and storage protein loci, as a principal determinant of cultivar‐specific nitrogen use efficiency in hexaploid wheat, independent of DNA sequence variation, and identifies the rhizosphere microbiome as an integral but ...
Baber Ali, Zeeshan Khan, Nijat Imin
wiley   +1 more source

HMDP and RG108 Supplementary Cardiac Methylome Data

Supplemental Files, Figures, and Tables for a methylome study of the heart in the HMDP under normal and Isoproterenol-stimulated conditions as well as the results of RG108 suppression of methyltransferase activity plus ISO stimulation in B6 and BTRBT ...
Rau, Christoph
core   +1 more source