Results 121 to 130 of about 37,526 (188)
Physical Fitness Is Negatively Associated With DNA Methylation‐Based Risk of Aging‐Related Diseases
Aging Cell, Volume 25, Issue 4, April 2026.We found 33 significant associations between DNA methylation–based protein level estimates (EpiScores) and fitness traits in older adults. Then we found 51 associations between fitness traits and chronic age‐related diseases, enabling a workflow for evaluating patient‐level disease risk by using DNA methylation and fitness measurements.
Samiha Nasser +7 more
wiley +1 more source
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]
, 2020 A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D +14 more
core +1 more source
Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 2, Page 260-269, April 2026.We selected breast cancer‐specific DNA methylation markers using The Cancer Genome Atlas (TCGA). We analyzed the methylation and expression patterns of candidate genes in breast cancer cell lines, ctDNA, and tissue samples. The relationship between ctDNA methylation markers and the clinicopathological features of breast cancer patients was investigated.
Young Ju Jeong +6 more
wiley +1 more source
The use of different types of networks, alone and in combination, for drug target identification
British Journal of Pharmacology, Volume 183, Issue 8, Page 1653-1662, April 2026.Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley +1 more source
Transcriptomic analysis of the interaction geminivirus-tomato [PDF]
, 2019 Geminiviridae family is one of the main families of plant pathogenic viruses with large relevance as they cause great losses worldwide in commercial crops and crops destined to food production.
Castillo-Garriga, Araceli +7 more
core
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Integration of epigenetics into ecotoxicology: insights and fundamental research needs
Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto +3 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundChronic stress is a critical challenge in fish aquaculture, adversely affecting growth, health, and overall productivity. Among the most significant chronic stressors in intensive farming is crowding, which triggers the release of cortisol, the
Daniela Aravena-Canales +11 more
doaj +1 more source
Molecular Ecology, Volume 35, Issue 7, April 2026.ABSTRACT Epigenomic changes are a hallmark of aging, and DNA methylation (DNAm) has emerged as the most reliable molecular marker of an individual's age. Genome‐wide patterns of age‐associated hypo‐ and hypermethylation have been applied to generate predictive models (i.e., “epigenetic clocks”) capable of estimating chronological age in an increasingly
Samantha L. Bock +25 more
wiley +1 more source
Plant Biology, Volume 28, Issue 3, Page 722-731, April 2026.Our factorial experimental design investigates the relationships between DNA methylation, plant development and individual fitness under stress in Erodium cicutarium. We found that epigenetic modifications associated to 5‐azacytidine seed treatment desynchronized plant growth and delayed flowering.
C. Alonso, M. Medrano, C. M. Herrera
wiley +1 more source