Results 101 to 110 of about 26,277 (245)

Charting the methylome

, 2011
Epigenetics, with DNA-methylation as its most stable feature, translates the genetic background into a particular phenotype. Massively parallel sequencing technologies opened up new possibilities for genome-wide profiling of DNA-methylation. Particularly
Van Criekinge, Wim, Van Criekinge, WimLA268010009727840000-0003-2971-5539F4D5440C-F0ED-11E1-A9DE-61C894A0A6B4, De Meyer, TimLA260019991023028010018740760000-0003-2994-9693F72F2AC4-F0ED-11E1-A9DE-61C894A0A6B4, Denil, SimonUGent0020050608298020008576769760552883510BECB3FA-F0EE-11E1-A9DE-61C894A0A6B4, Denil, Simon, De Meyer, Tim, Trooskens, GeertUGent0019994599868020005745589745321606051C07D0DA-F0EE-11E1-A9DE-61C894A0A6B4, Trooskens, Geert   +7 more
core  

Charting the dynamic methylome across the human lifespan [PDF]

, 2017
In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data ...
Slieker, RC, Slieker, R.
core  

Analysis of Methylome, Transcriptome, and Lipid Metabolites to Understand the Molecular Abnormalities in Polycystic Ovary Syndrome

, 2023
Fei Zhang,1 Yicen Ding,1 Bohan Zhang,1 Mengju He,1 Zhijiang Wang,2 Chunbo Lu,3 Yani Kang1 1School of Biomedical Engineering, Bio-ID Center, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Pharmaceutical Engineering ...
Zhang F, Ding Y, He M, Lu C, Zhang B, Wang Z, Kang Y   +6 more
core  

Additional file 6 of Whole blood methylome-derived features to discriminate endocrine hypertension

, 2022
Additional file 6: Table S6.
Piotr Dobrowolski (2333500), Anne Jouinot (13503469), Maria-Christina Zennaro (550008), Aleksander Prejbisz (6094328), Scott M. MacKenzie (7951616), Anne-Paule Gimenez-Roqueplo (75862), Leah Braun (10176329), Matthias Kroiss (619591), Gian Paolo Rossi (8450145), Livia Lenzini (14057056), Guillaume Assié (608455), Laurence Amar (370380), Carla Scaroni (392961), Smarti Reel (14057041), Emily Jefferson (14057062), Roberta Armignacco (14057035), Paolo Mulatero (10773219), Amandine Septier (9740169), Casper K. Larsen (14057047), Eleanor Davies (14057053), Martin Reincke (150169), Parminder S. Reel (14057038), Tracy A. Williams (14057059), Karine Perlemoine (280567), Andrzej Januszewicz (6094331), Alessio Pecori (9622913), Lucas Bouys (14057050), Cassandra Gaspar (14057044), Fidéline Bonnet-Serrano (4782546), Filippo Ceccato (597703), Jérôme Bertherat (140471), Silvia Monticone (10773222), Felix Beuschlein (158361), Anna Riester (9103990), Anne Blanchard (480536)   +34 more
core   +1 more source

Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes

Cell Reports, 2017
Although DNA modifications play an important role in gene regulation, the underlying mechanisms remain elusive. We developed EpiSELEX-seq to probe the sensitivity of transcription factor binding to DNA modification in vitro using massively parallel ...
Judith F. Kribelbauer, Oleg Laptenko, Siying Chen, Gabriella D. Martini, William A. Freed-Pastor, Carol Prives, Richard S. Mann, Harmen J. Bussemaker   +7 more
doaj   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Comparative Methylome Analysis Reveals Perturbation of Host Epigenome in Chestnut Blight Fungus by a Hypovirus

Frontiers in Microbiology, 2018
In eukaryotic genomes, DNA methylation is an important type of epigenetic modification that plays crucial roles in many biological processes. To investigate the impact of a hypovirus infection on the methylome of Cryphonectria parasitica, the chestnut ...
Ru Li, Ru Li, Sisi Zhou, Yongbing Li, Xiaorui Shen, Zhiqiang Wang, Baoshan Chen, Baoshan Chen   +7 more
doaj   +1 more source

Childhood internalising symptoms at ages 3 and 6: a meta‐analysis of epigenome‐wide associations from cord and peripheral blood

Journal of Child Psychology and Psychiatry, EarlyView.
Background Pre‐ and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems.
Laura Schellhas, Mannan Luo, Janine F. Felix, Christian M. Page, Mona Bekkhus, Marcus R. Munafò, Luisa Zuccolo, Alexandra Havdahl, Charlotte A.M. Cecil, Gemma C. Sharp   +9 more
wiley   +1 more source

Comparative transcriptome and methylome of polar bears, giant and red pandas reveal diet‐driven adaptive evolution

Evolutionary Applications
Epigenetic regulation plays an important role in the evolution of species adaptations, yet little information is available on the epigenetic mechanisms underlying the adaptive evolution of bamboo‐eating in both giant pandas (Ailuropoda melanoleuca) and ...
Lei Chen, Jinnan Ma, Wencai Xu, Fujun Shen, Zhisong Yang, Christian Sonne, Rune Dietz, Linzhu Li, Xiaodie Jie, Lu Li, Guoqiang Yan, Xiuyue Zhang   +11 more
doaj   +1 more source

DNA methylome responses to biotic and abiotic stress in Arabidopsis thaliana: A multi‐study analysis

Plant Biology, EarlyView.
Sixteen Arabidopsis thaliana Whole‐Genome Bisulfite Sequencing datasets have been analysed to reveal common and stress‐specific DNA methylation responses. Although global methylation levels remained stable, specific DMRs varied according to the type of stress and genomics context.
R. Behl, J. J. Gallo‐Franco, R. R. Hazarika, Z. Zhang, F. Wilming, J. P. Schnitzler, C. Lindermayr, F. Johannes   +7 more
wiley   +1 more source