Results 91 to 100 of about 26,277 (245)

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

The DNA Methylome of Human Peripheral Blood Mononuclear Cells [PDF]

, 2010
DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells.
Yu, Jian, Zhang, XQ, Xin Li, Cao, Hongzhi, Chen, MF, Sun, Jinfeng, Li, Xin, Shicheng Guo, Jinfeng Sun, Bolund, Lars, Zheng, Hancheng, Chen, Minfeng, Minfeng Chen, Li, Qibin, Yang, Huanming, Yang, HM, Zhang, Xiuqing, Li, YR, Beck, S, Li, QB, Jun Wang, Chang Yu, Wu, Honglong, Zheng, Huisong, Huisong Zheng, Yu, Chang, Li, Ruiqiang, Jin, Xin, Xiuqing Zhang, Cao, HZ, Huang, YB, He, Yinghua, Wang, J, Jian Yu, Jin, X, Quan Chen, Ruiqiang Li, Li, RQ, Wang, W, Li, Ning, Wang, Jian, Zhang, HY, Qibin Li, Zhang, QH, Hu, XD, Xueda Hu, Li, Yingrui, Hancheng Zheng, Yebo Huang, Zhu, Jingde, Hongyu Zhang, Jihua Sun, Wang, JA, Jiujin Xu, Chen, QA, Mingzhi Ye, Yu, JA, Yingrui Li, Zhou, XY, Wu, HL, Huang, Yebo, Kristiansen, K, Yu, C, Zhou, Xiaoyu, Chen, Quan, Zheng, HS, He, YH, Xin Jin, Guo, Shicheng, Bolund, L, Geng Tian, Ruibang Luo, Guangyu Zhou, Zhang, Qinghui, Huanming Yang, Xu, Jiujin, Sun, JH, Sun, JF, Lars Bolund, Luo, RB, Zhou, GY, Hu, Xueda, Li, N, Tian, Geng, Ye, Mingzhi, Wang, Wen, Karsten Kristiansen, Ye, MZ, Beck, Stephan, Tian, G, Stephan Beck, Jingde Zhu, Guo, SC, Kristiansen, Karsten, Luo, Ruibang, Sun, Jihua, Hongzhi Cao, Zhang, Hongyu, Qinghui Zhang, Yinghua He, Xiaoyu Zhou, Zhou, Guangyu, Zheng, HC, Wang, Jun, Honglong Wu, Jian Wang, Li, X, Ning Li, Zhu, JD, Xu, JJ, Wen Wang   +110 more
core   +1 more source

Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting

Brain Pathology, EarlyView.
Using the Infinium MethylationEPIC v2.0 array and Heidelberg Brain Tumor Classifier v12.8, 24 international laboratories achieved highly reproducible CNS tumor classification (97.9% correct; median β‐correlation r = 0.99), while copy number variation interpretation showed substantial interlaboratory variability, highlighting the need for harmonized CNV
Katrin Mauch‐Mücke, Christin Siewert, Lora Dimitrova, Sandra Pohl, Brendan Osberg, Annika K. Wefers, Julia Lorenz, Tanja Rothhammer‐Hampl, Till Acker, Alonso Barrantes‐Freer, Jean Boutonnat, Bérengère Dadone‐Montaudié, Claire Delbridge, Wolfgang Dietmaier, Sebastian Dintner, Hildegard Dohmen, Matthias Dottermusch, Daniel Erny, Katrin B. M. Frauenknecht, Tobias Goschzik, Patrick N. Harter, Daniela Hirsch, Yanghao Hou, Theo F. J. Kraus, Maggie Lee, Friederike Liesche‐Starnecker, Anne Mc Leer, Linea Melchior, Michael Mittelbronn, Wolf C. Müller, Shalima S. Nair, Julia E. Neumann, Pitt Niehusmann, Nicole Pfarr, Torsten Pietsch, Marco Prinz, Markus Rechsteiner, Regina Reimann, Laveniya Satgunaseelan, Veronica Skarpeteig, Anne J. Skjulsvik, Karl Sotlar, Isabelle Vanden Bempt, Erik Vassella, Katharina J. Weber, Gabriel Wasinger, Andreas Waha, Karen Zwaenepoel, Felix Sahm, Markus J. Riemenschneider, David Capper   +50 more
wiley   +1 more source

Single Base-Resolution Methylome of the Dizygotic Sheep. [PDF]

, 2015
Sheep is an important livestock in the world for meat, dairy and wool production. The third version of sheep reference genome has been recently assembled, but sheep DNA methylome has not been profiled yet. In this study, we report the comprehensive sheep
Yang Dong (234336), Wang, Yangzi, Jianghong Wu, Jianghong Wu (605442), Wang, Wen, Dong, Yang, Xiao Ma, Wu, Jianghong, Bin Liu (5899), Liu, Bin, Rui Su, Yangzi Wang (822124), Yang Dong, Xiao Ma (411875), Yangzi Wang, Yu Jiang (234328), Yu Jiang, Rui Su (822125), Su, Rui, Bin Liu, Wen Wang (6570), Wen Wang, Ma, Xiao, Jiang, Yu   +23 more
core   +1 more source

Mapping the minutiae of the human methylome

Nature Reviews Genetics, 2023
A study in Nature reports comprehensive, genome-wide mapping of the human methylome that provides mechanistic insights into gene regulation and offers great potential for analysis of cell-free DNA.
openaire   +2 more sources

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, EarlyView.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

Additional file 3: of DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer

, 2019
DNA methylome-wide results in biphenol-treated MCF-7 cells and in TCGA breast cancer patients. DNA methylome-wide results (DMPs and DMRs) of MCF-7 cells treated with BPA, BPF and BPS ± ERI for 48 hrs and DNA methylome-wide results (DMPs) of ER ...
M. Zhivagui (7487516), R. Akika (7487510), V. Cahais (7487513), Z. Herceg (6548078), A. Ghantous (6548000), N. Zgheib (7487519), C. Cuenin (6548003), R. Nasr (7487507), Z. Awada (7487504)   +8 more
core   +1 more source

The DNA methylome of glioblastoma multiforme

Neurobiology of Disease, 2010
Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults. This lethal cancer is a challenge in neuro-oncology since patients almost invariably succumb to the disease. Intensive molecular studies have revealed a variety of deregulated genetic pathways involved in DNA repair, apoptosis, cell migration, angiogenesis and cell cycle.
Ramon Martinez, Manel Esteller
openaire   +3 more sources

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source