Results 91 to 100 of about 37,526 (188)

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties [PDF]

, 2019
Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are among the most frequently tested cellular therapeutics for treating degenerative and immune disorders, which occur predominantly in the aging population.
Andrzejewska, Anastazja, Beez, Christien, Blankenstein, Antje, Catar, Rusan, Duda, Georg, Geissler, Sven, Jacobi, Dorit, Jürchott, Karsten, Kamhieh-Milz, Julian, Krüger, David, Krüger, Ulrike, Moll, Guido, Qazi, Taimoor Hasan, Reinke, Petra, Reinke, Simon, Richter, Sarina, Sass, Frauke Andrea, Schlickeiser, Stephan, Schoon, Janosch, Souidi, Naima, Streitz, Mathias, Strunk, Dirk, Zemojtel, Tomasz   +22 more
core   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Post‐surgery level of circulating DNA in stage III colon cancer patients: Impact on the reliability of minimal residual disease detection

International Journal of Cancer, Volume 158, Issue 10, Page 2771-2783, 15 May 2026.
What's New? Circulating nuclear DNA (cir‐nDNA)‐based assessment of minimal residual disease (MRD) offers powerful post‐surgery prognostic insight for stage III colon cancer (CC). Sparse knowledge of post‐surgical variations and origins in cir‐nDNA, however, has limited its clinical application.
Andrei Kudriavtsev, Saidi Daoud, Catalina Isabel Cofre Muñoz, Alexia Mirandola, Ekaterina Pisareva, Javier Gonzalo Ruiz, Marco Macagno, Nadia Saoudi Gonzalez, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, Alain R. Thierry   +17 more
wiley   +1 more source

The Genome and Methylome of a Subsocial Small Carpenter Bee, Ceratina calcarata [PDF]

, 2016
Understanding the evolution of animal societies, considered to be a major transition in evolution, is a key topic in evolutionary biology. Recently, new gateways for understanding social evolution have opened up due to advances in genomics, allowing for ...
Glastad, Karl M., Hunt, Brendan G., Lawson, Sarah P., Rehan, Sandra M.   +3 more
core   +2 more sources

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source

Comparative transcriptome and methylome of polar bears, giant and red pandas reveal diet‐driven adaptive evolution

Evolutionary Applications
Epigenetic regulation plays an important role in the evolution of species adaptations, yet little information is available on the epigenetic mechanisms underlying the adaptive evolution of bamboo‐eating in both giant pandas (Ailuropoda melanoleuca) and ...
Lei Chen, Jinnan Ma, Wencai Xu, Fujun Shen, Zhisong Yang, Christian Sonne, Rune Dietz, Linzhu Li, Xiaodie Jie, Lu Li, Guoqiang Yan, Xiuyue Zhang   +11 more
doaj   +1 more source

Structural basis for DNMT3A-mediated de novo DNA methylation. [PDF]

, 2018
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at cytosines is essential for genome regulation and development. Dysregulation of this process is implicated in various diseases, notably cancer.
Chen, Dongliang, Gao, Linfeng, Ji, Debin, Liu, Shuo, Lu, Rui, Rothbart, Scott B, Song, Jikui, Wang, Gang Greg, Wang, Pengcheng, Wang, Yinsheng, Yu, Yang, Zhang, Zhi-Min   +11 more
core   +2 more sources

At the Right Time: Temporal Precision in Personalised Medicine

Sociology of Health &Illness, Volume 48, Issue 4, May 2026.
ABSTRACT Personalised medicine was initially heralded as delivering ‘the right drug to the right patient at the right time’. Although molecular precision has dominated recent developments, the temporal dimension has remained underexplored. This paper examines how temporal precision is emerging as a defining feature of next‐generation precision medicine,
Dominik Hofmann, Elena Esposito
wiley   +1 more source

Profiling genome‐wide methylation in two maples: Fine‐scale approaches to detection with nanopore technology

Evolutionary Applications
DNA methylation is critical to the regulation of transposable elements and gene expression and can play an important role in the adaptation of stress response mechanisms in plants.
Susan L. McEvoy, Patrick G. S. Grady, Nicole Pauloski, Rachel J. O'Neill, Jill L. Wegrzyn   +4 more
doaj   +1 more source

Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]

, 2014
peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core   +2 more sources