Results 71 to 80 of about 37,526 (188)

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, EarlyView.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

Loss of Endometrial Plasticity in Recurrent Pregnancy Loss [PDF]

, 2015
© 2015 AlphaMed Press.Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation of stromal cells, which differentiate into specialized decidual cells prior to and during pregnancy.
Brighton, PJ, Brosens, JJ, Chan, JKY, Chan, YW, Dyer, NP, Grimaldi, G, Hou Lee, Y, Lam, EWF, Lucas, ES, Moore, JD, Murakami, K, Muter, J, Ott, S, Patel, G, Quenby, S, Takeda, S   +15 more
core   +1 more source

Large-scale and significant expression from pseudogenes in Sodalis glossinidius – a facultative bacterial endosymbiont [PDF]

, 2020
The majority of bacterial genomes have high coding efficiencies, but there are some genomes of intracellular bacteria that have low gene density. The genome of the endosymbiont Sodalis glossinidius contains almost 50 % pseudogenes containing mutations ...
Beynon, R, Blow, F, Brownridge, P, Darby, AC, Goodhead, IB, Hughes, M, Kenny, J, Krishna, R, McLean, L, Pongchaikul, P   +9 more
core   +2 more sources

Genome‐wide and gene‐specific DNA methylation across developmental stages in Pogonomyrmex californicus: A socially polymorphic ant

Insect Molecular Biology, EarlyView.
Comparison between developmental stages (larvae, pupae, worker) in Pogonomyrmex californicus revealed significant stage‐specific differences in Gene Body Methylated frequencies. Methylation sites were highly correlated between WGBS and ONT in P. californicus Genome‐wide methylation was low (~3%) and highly clustered within gene bodies (GBM), especially
Tania Chavarria‐Pizarro, Mohammed Errbii, Janina Rinke, Lukas Schrader, Jürgen Gadau   +4 more
wiley   +1 more source

Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility

Frontiers in Cellular and Infection Microbiology
ObjectiveThe study delved into the epigenetic factors associated with periodontal disease in two lineages of mice, namely C57bl/6 and Balb/c. Its primary objective was to elucidate alterations in the methylome of mice with distinct genetic backgrounds ...
Cristhiam de Jesus Hernandez Martinez, Cristhiam de Jesus Hernandez Martinez, Joseph Glessner, Joseph Glessner, Joseph Glessner, Livia Sertori Finoti, Pedro Felix Silva, Michel Messora, Ricardo Della Coletta, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson, Hakon Hakonarson, Daniela Bazan Palioto   +14 more
doaj   +1 more source

Depression and suicide risk prediction models using blood-derived multi-omics data [PDF]

, 2019
More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models
Bhak, Jong, Bhak, Youngjune, Blazyte, Asta, Cho, Juok, Cho, Yun Sung, Gim, Jeong-An, Ham, Byung-Joo, Jeon, Sungwon, Jeon, Yeonsu, Jeong, Hyoung-oh, Kang, Wooyoung, Kim, Aram, Kim, Byung Chul, Kim, Hak-Min, Kim, Yumi, Lee, Hae-Woo, Lee, Semin, Paik, Jong-Woo, Park, Seung Gu, Shin, Eun-Seok   +19 more
core   +1 more source

Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Salivary microvesicles (MVs) are nanosized extracellular vesicles from the host and microbiota whose cargo may mirror the biological state of their parent cells. This cross‐sectional study aimed to explore the diagnostic power of host methylome and microbiome profiles of MVs in various periodontal disease states. Materials and Methods This
Pingping Han, Chaminda Seneviratne, Qiongyi Zhao, Carlos Salomon, Xiang Li, Sašo Ivanovski   +5 more
wiley   +1 more source

Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]

, 2018
All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane, Callewaert, Nico, De Koker, Andries   +2 more
core   +2 more sources

Challenges in Bringing Pangenome Research Into Breeding: A Case Study in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Crop breeding has entered the pangenomics era, unlocking a far more comprehensive view of genetic diversity than a single reference genome can capture. In rice (Oryza sativa), a staple crop critical to global food security, the construction of pangenome resources has uncovered extensive structural variations (SVs), presence/absence variations (
Shuai Nie, Fangping Li, Risheng Li, Jian Wang, Yamei Ma, Chon Kit Kenneth Chan, Junliang Zhao, Haifei Hu   +7 more
wiley   +1 more source

Stability of Blood DNA Methylation Across Two Timepoints in Three Cohorts

Biomedicines
Background: DNA methylation mediates the gene–environment interactions, with implications for health and disease. Studies with sampling at more than one timepoint revealed the considerable variability of the blood methylome, but comprehensive resources ...
Mikołaj Danielewski, Jarosław Walkowiak, Karolina Wielgus, Jan Krzysztof Nowak   +3 more
doaj   +1 more source