Results 61 to 70 of about 37,526 (188)

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

Journal of Fungi
Gerronema lapidescens (Lei Wan), a valued medicinal basidiomycete traditionally employed for antiparasitic and digestive ailments, faces severe conservation threats due to unsustainable wild harvesting and the absence of reliable cultivation protocols ...
Yanming Qiao, Zhiyuan Jia, Yuying Liu, Na Zhang, Chun Luo, Lina Meng, Yajie Cheng, Minglei Li, Xiuchao Xie, Jianzhao Qi   +9 more
doaj   +1 more source

Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis

Frontiers in Genetics, 2020
Rheumatoid arthritis (RA) is a common autoimmune disorder influenced by both genetic and environmental factors. To investigate possible contributions of DNA methylation to the etiology of RA with minimum confounding genetic heterogeneity, we investigated
Xin Feng, Xin Feng, Xin Feng, Xubing Hao, Ruoyao Shi, Zhiqiang Xia, Lan Huang, Qiong Yu, Fengfeng Zhou   +8 more
doaj   +1 more source

Infection with a Virulent Strain of Wolbachia Disrupts Genome Wide-Patterns of Cytosine Methylation in the Mosquito Aedes aegypti [PDF]

, 2015
BACKGROUND Cytosine methylation is one of several reversible epigenetic modifications of DNA that allow a greater flexibility in the relationship between genotype and phenotype.
Caragata, Eric P., Huttley, Gavin A., McGraw, Elizabeth A., O'Neill, Scott L., Popovici, Jean, Rancès, Edwige, Woolfit, Megan, Ye, Yixin H.   +7 more
core   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing

Frontiers in Epigenetics and Epigenomics
IntroductionPreterm birth (PTB), a leading cause of neonatal morbidity and mortality, arises from complex maternal-fetal interactions with multifactorial origins.
BalaSubramani Gattu Linga, BalaSubramani Gattu Linga, Faisal E. Ibrahim, Faisal E. Ibrahim, Faisal E. Ibrahim, Aleem Razzaq, Aleem Razzaq, Muthanna Samara, Jameela Roshanuddin, Jameela Roshanuddin, Hind H. Adi, Hind H. Adi, Aseel Al-Dewik, Aseel Al-Dewik, Aseel Al-Dewik, Ayla J. Ahmedoglu, Ayla J. Ahmedoglu, Rand Hamdan, Rand Hamdan, Amal E. I. Ahmed, Amal E. I. Ahmed, Amal E. I. Ahmed, M. Walid Qoronfleh, Hatem Zayed, Duaa Elshiekh, Mona Ellaithi, Mohamed Alsharshani, Palli Valapila Abdulrouf, Palli Valapila Abdulrouf, Thomas Farrell, Thomas Farrell, Thomas Farrell, Bader Kurdi, Ghassan Abdoh, Hilal Al Rifai, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik, Nader Al-Dewik   +41 more
doaj   +1 more source

Networking and Specificity-Changing DNA Methyltransferases in Helicobacter pylori

Frontiers in Microbiology, 2020
Epigenetic DNA base methylation plays important roles in gene expression regulation. We here describe a gene expression regulation network consisting of many DNA methyltransferases each frequently changing its target sequence-specificity.
Hirokazu Yano, Hirokazu Yano, Md. Zobaidul Alam, Emiko Rimbara, Tomoko F. Shibata, Masaki Fukuyo, Yoshikazu Furuta, Yoshikazu Furuta, Tomoaki Nishiyama, Shuji Shigenobu, Mitsuyasu Hasebe, Mitsuyasu Hasebe, Atsushi Toyoda, Yutaka Suzuki, Sumio Sugano, Sumio Sugano, Keigo Shibayama, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi, Ichizo Kobayashi   +21 more
doaj   +1 more source

A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis

Brain Pathology, EarlyView.
circRMST (hsa_circ_0099634) is by far the most abundant isoform from the RMST locus. It is highly expressed in cancer cells throughout ependymoma patient samples and is located in the cytoplasm. circRMST knockdown causes cell cycle arrest and induces differentiation, and it is a marker for poor prognosis. The figure is made using BioRender.
Ulvi Ahmadov, Charlotte W. Udengaard, Stine M. Vissing, Silke D. Nielsen, Kim‐Gwendolyn Dietrich, Benedicte Parm Ulhøi, Lasse S. Kristensen   +6 more
wiley   +1 more source

Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm

Epigenetics
A global priority for ameliorating male factor infertility includes identification of environmental factors and mechanisms that impact sperm function. Detection of endocrine disrupting chemicals (EDC) in seminal plasma and within the female reproductive ...
Muhammad S. Siddique, Santosh Anand, Marie-Pierre L. Gauthier, Jason O. Brant, Michael P. Kladde, Ramji K. Bhandari, Bradford W. Daigneault   +6 more
doaj   +1 more source

DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. [PDF]

, 2018
An algorithm assessing the methylation levels of 353 informative CpG sites in the human genome permits accurate prediction of the chronologic age of a subject.
Bedard, Jenna, Landis, Jessica, Marin, Diego, Morin, Scott J., Scott, Richard T., Seli, Emre, Tao, Xin, Zhan, Yiping   +7 more
core   +1 more source