Results 201 to 210 of about 26,277 (245)
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Advent of the Cancer Methylome
Combinatorial Chemistry & High Throughput Screening, 2012DNA hypermethylation of CpG islands plays an important role in gene regulation during cancer development. Many techniques have been developed to detect global DNA methylation in cancer cells compared to normal tissues. This knowledge helps us to better understand cancer progression and also aids in the development of new biomarker for early cancer ...
Huey Shan, Nai, Quek Choon, Lau
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Making sense of the ageing methylome
Nature Reviews Genetics, 2022Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases, including cardiovascular disease and cancer. Various age-related DNA methylation changes have been described, including at the level of individual CpGs, such as differential and variable methylation, and at ...
Kirsten Seale +4 more
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Blood, 2010
In this issue of Blood, Schafer and colleagues report their findings on MLL-r infant ALL. 1 They examined global promoter methylation in infants and found hypermethylation in cases with MLL-r ALL compared with both the normal and non-MLL-r ALL cases. When treating MLL-r cell lines with decitabine, they observed a reexpression of silenced genes and a ...
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In this issue of Blood, Schafer and colleagues report their findings on MLL-r infant ALL. 1 They examined global promoter methylation in infants and found hypermethylation in cases with MLL-r ALL compared with both the normal and non-MLL-r ALL cases. When treating MLL-r cell lines with decitabine, they observed a reexpression of silenced genes and a ...
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Locking in on the human methylome
Nature Biotechnology, 2009Two groups have combined padlock probes and massively parallel sequencing to characterize cytosine methylation in targeted regions of the human genome.
Benjamin P, Berman +2 more
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Guardians of the oocyte methylome
Nature Reviews Molecular Cell Biology, 2018STELLA protects the genome of mouse oocytes from de novo DNA methylation by the E3 ubiquitin ligase UHRF1 and the DNA methyltransferase DNMT1.
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Sequencing the Cancer Methylome
2014DNA methylation is the most studied epigenetic event in cancer, with focus being placed on studying the entire DNA methylation landscape in specific cancers. Due to the recent advances of next-generation sequencing technology, several effective methods have been developed for high-throughput analysis of DNA methylation, enabling DNA methylation markers
Austin Y, Shull +4 more
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Methylome Imputation by Methylation Patterns
2023DNA methylation is studied extensively for its relations with several biological processes such as transcriptional regulation. While methylation levels are usually estimated per cytosine or genomic region, additional information on methylation heterogeneity can be obtained when considering stretches of successive cytosines on the same reads; however ...
Ya-Ting Sabrina, Chang +2 more
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Taking the measure of the methylome
Nature Biotechnology, 2010Two comparative studies from the International Human Epigenome Project find high concordance between different methods for measuring genomic methylation.
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Tracking the evolution of cancer methylomes
Nature Genetics, 2012Cellular transformation in cancer has long been associated with aberrant DNA methylation, most notably, hypermethylation of promoter sequences. A new study uses a clever approach of selective high-resolution profiling to follow DNA methylation over a time course of cellular transformation and challenges the notion that hypermethylation in cancer arises
Arnaud R Krebs, Dirk Schübeler
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Exposing the DNA methylome iceberg
Trends in Biochemical Sciences, 2011DNA methylation was the first epigenetic modification discovered. Until recently, comprehensive coverage of the composition and distribution of methylated cytosines across the genome was lacking. Technological advances, however, are providing methylation maps that can reveal the genomic distribution of DNA methylation in different cell states or ...
Ndlovu, Matladi N. +2 more
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