Results 211 to 220 of about 26,277 (245)
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Nature Reviews Genetics, 2018
A study in Nature Medicine reports the DNA methylome and transcriptome of an individual, and suggests that changes in the methylome and transcriptome might be associated with chronic and acute health conditions, respectively.
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A study in Nature Medicine reports the DNA methylome and transcriptome of an individual, and suggests that changes in the methylome and transcriptome might be associated with chronic and acute health conditions, respectively.
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Epigenomics: Sequencing the Methylome
2013DNA methylation patterns are increasingly surveyed through methods that utilize massively parallel sequencing. Sequence-based assays developed to detect DNA methylation can be broadly divided into those that depend on affinity enrichment, chemical conversion, or enzymatic restriction.
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Science, 2010
The patterns of DNA methylation across the genomes of 20 eukaryotes reveal conserved features and specific roles during evolution.
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The patterns of DNA methylation across the genomes of 20 eukaryotes reveal conserved features and specific roles during evolution.
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The DNA methylome: a novel biomarker
Blood, 2014In this issue of Blood, Chambwe and colleagues demonstrate the presence of promoter methylation variability in diffuse large B-cell lymphomas (DLBCLs).1 This methylation variability correlates with the expression of specific genes and is associated with distinct survival following standard therapy—a finding that has numerous implications for our ...
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Unraveling the DNA methylome of atherosclerosis
Current Opinion in Lipidology, 2014Epigenetic mechanisms of transcriptional regulation in atherosclerosis have gained an increasing interest in recent years. We focus on the relevance of DNA methylation, a well characterized epigenetic modification of the genome, as a biomarker and underlying mechanism of atherosclerosis.A growing number of loci have been identified, which are good ...
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Obesity and the breast cancer methylome
Current Opinion in Pharmacology, 2016Breast cancer is associated with risk factors such as advancing age and obesity. However, the linkages between these risk factors for breast cancer development and initiation of the disease are not yet clear. Obesity may drive breast cancer development through increases in circulating estrogens in postmenopausal women.
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Bacterial DNA Methylation and Methylomes
2016Formation of C5-methylcytosine, N4-methylcytosine, and N6-methyladenine in bacterial genomes is postreplicative and involves transfer of a methyl group from S-adenosyl-methionine to a base embedded in a specific DNA sequence context. Most bacterial DNA methyltransferases belong to restriction-modification systems; in addition, "solitary" or "orphan ...
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The Chinese pine genome and methylome unveil key features of conifer evolution
Cell, 2022Yue Li, Jiang Li, Yanjun Zan
exaly
Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise
American Journal of Physiology - Endocrinology and Metabolism, 2023José Areta +2 more
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Methylome Profiling in Fabry Disease in Clinical Practice: A Proof of Concept
International Journal of Molecular Sciences, 2022Roberta Visconti +2 more
exaly