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Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure [PDF]
EpigeneticsHistone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood.
Samuel Hickenlooper +12 more
doaj +2 more sources
Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
Biomolecules, 2021 The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines.
Sebastián Miranda-Rojas +4 more
doaj +1 more source
Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers
Biology, 2021 The KMT2 (MLL) family of proteins, including the major histone H3K4 methyltransferase found in mammals, exists as large complexes with common subunit proteins and exhibits enzymatic activity.
Liu Yang, Mingli Jin, Kwang Won Jeong
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A comprehensive review of m6A/m6Am RNA methyltransferase structures
Nucleic Acids Research, 2021 Gene expression is regulated at many levels including co- or post-transcriptionally, where chemical modifications are added to RNA on riboses and bases.
S. Oerum +3 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed.
Kyung Taek Heo +6 more
doaj +1 more source
Frontiers in Microbiology, 2022 Dichloromethane (DCM; CH2Cl2) is a widespread pollutant with anthropogenic and natural sources. Anaerobic DCM-dechlorinating bacteria use the Wood–Ljungdahl pathway, yet dechlorination reaction mechanisms remain unclear and the enzyme(s) responsible for ...
Sophie I. Holland +7 more
doaj +1 more source
Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury
Frontiers in Cell and Developmental Biology, 2022 Histone H3 lysine 4 (H3K4) methyltransferase 2D (KMT2D) plays an important role in cell development in early life. However, the function of KMT2D in adult cells such as cardiomyocytes or neurons has not been reported.
Shu-Bao Liu +6 more
doaj +1 more source
A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
Biomolecules, 2021 Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and
Iredia D. Iyamu +2 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
doaj +1 more source
Recent progress in DNA methyltransferase inhibitors as anticancer agents
Frontiers in Pharmacology, 2022 DNA methylation mediated by DNA methyltransferase is an important epigenetic process that regulates gene expression in mammals, which plays a key role in silencing certain genes, such as tumor suppressor genes, in cancer, and it has become a promising ...
Zhixiong Zhang +7 more
semanticscholar +1 more source