Results 1 to 10 of about 339,003 (291)

Methyltransferases of Riboviria

Biomolecules, 2022
Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
doaj   +3 more sources

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2022
The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang, Runjiao Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Fangzhen Guo, Fangzhen Guo, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +12 more
doaj   +1 more source

Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential

Biomolecules, 2022
Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as RNA splicing, cell proliferation, cell cycle, and embryonic development.
Yongfei Fan, Xinwei Li, Huihui Sun, Zhaojia Gao, Zheng Zhu, Kai Yuan   +5 more
doaj   +1 more source

Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study

Biomolecules, 2021
The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines.
Sebastián Miranda-Rojas, Kevin Blanco-Esperguez, Iñaki Tuñón, Johannes Kästner, Fernando Mendizábal   +4 more
doaj   +1 more source

Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers

Biology, 2021
The KMT2 (MLL) family of proteins, including the major histone H3K4 methyltransferase found in mammals, exists as large complexes with common subunit proteins and exhibits enzymatic activity.
Liu Yang, Mingli Jin, Kwang Won Jeong
doaj   +1 more source

Elucidation of the di-c-glycosylation steps during biosynthesis of the antitumor antibiotic, kidamycin

Frontiers in Bioengineering and Biotechnology, 2022
Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed.
Kyung Taek Heo, Kyung Taek Heo, Byeongsan Lee, Jae-Hyuk Jang, Jae-Hyuk Jang, Young-Soo Hong, Young-Soo Hong   +6 more
doaj   +1 more source

Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury

Frontiers in Cell and Developmental Biology, 2022
Histone H3 lysine 4 (H3K4) methyltransferase 2D (KMT2D) plays an important role in cell development in early life. However, the function of KMT2D in adult cells such as cardiomyocytes or neurons has not been reported.
Shu-Bao Liu, Xiang-Min Meng, Yu-Meng Li, Jun-Meng Wang, Hui-Hui Guo, Chaochen Wang, Bing-Mei Zhu   +6 more
doaj   +1 more source

Metaproteomics reveals methyltransferases implicated in dichloromethane and glycine betaine fermentation by ‘Candidatus Formimonas warabiya’ strain DCMF

Frontiers in Microbiology, 2022
Dichloromethane (DCM; CH2Cl2) is a widespread pollutant with anthropogenic and natural sources. Anaerobic DCM-dechlorinating bacteria use the Wood–Ljungdahl pathway, yet dechlorination reaction mechanisms remain unclear and the enzyme(s) responsible for ...
Sophie I. Holland, Xabier Vázquez-Campos, Haluk Ertan, Haluk Ertan, Richard J. Edwards, Michael J. Manefield, Michael J. Manefield, Matthew Lee   +7 more
doaj   +1 more source

Targeting NSP16 Methyltransferase for the Broad-Spectrum Clinical Management of Coronaviruses: Managing the Next Pandemic

Diseases, 2021
With the approval and distribution of demonstrably safe COVID-19 vaccines bearing exceptionally high efficacy profiles, it may be tempting to envision a return to “normal” in the coming months.
Ilham M. Alshiraihi, Gerald L. Klein, Mark A. Brown   +2 more
doaj   +1 more source

Gene Expression Profiles of Methyltransferases and Demethylases Associated with Metastasis, Tumor Invasion, CpG73 Methylation, and HPV Status in Head and Neck Squamous Cell Carcinoma

Current Issues in Molecular Biology, 2023
Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan, Tomaž Büdefeld, Helena Čelešnik, Matija Švagan, Boštjan Lanišnik, Uroš Potočnik   +5 more
doaj   +1 more source