Results 1 to 10 of about 362,844 (312)
Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. [PDF]
, 2013 Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits.
Clarke, Steven G +3 more
core +11 more sources
A comprehensive review of m6A/m6Am RNA methyltransferase structures
Nucleic Acids Research, 2021 Gene expression is regulated at many levels including co- or post-transcriptionally, where chemical modifications are added to RNA on riboses and bases.
S. Oerum +3 more
semanticscholar +1 more source
RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2022 The importance of epitranscriptomics in regulating gene expression has received widespread attention. Recently, RNA methylation modifications, particularly N6-methyladenosine (m6A), have received marked attention.
Runjiao Zhang +12 more
doaj +1 more source
Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) has poor prognosis and is usually diagnosed only at an advanced stage. Identification of novel biomarkers is critical to early diagnosis and better prognosis for HCC patients.
Zongting Gu +3 more
doaj +1 more source
Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury
Frontiers in Cell and Developmental Biology, 2022 Histone H3 lysine 4 (H3K4) methyltransferase 2D (KMT2D) plays an important role in cell development in early life. However, the function of KMT2D in adult cells such as cardiomyocytes or neurons has not been reported.
Shu-Bao Liu +6 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed.
Kyung Taek Heo +6 more
doaj +1 more source
Frontiers in Microbiology, 2022 Dichloromethane (DCM; CH2Cl2) is a widespread pollutant with anthropogenic and natural sources. Anaerobic DCM-dechlorinating bacteria use the Wood–Ljungdahl pathway, yet dechlorination reaction mechanisms remain unclear and the enzyme(s) responsible for ...
Sophie I. Holland +7 more
doaj +1 more source
The University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) Dataset [PDF]
Radiology: Artificial Intelligence 4.6 (2022): e220058, 2021 Here we present the University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) dataset. The UCSF-PDGM dataset includes 500 subjects with histopathologically-proven diffuse gliomas who were imaged with a standardized 3 Tesla preoperative brain tumor MRI protocol featuring predominantly 3D imaging, as well as advanced diffusion ...
arxiv +1 more source
Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
doaj +1 more source
Clinical Epigenetics, 2021 DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses.
Chunhong Hu +4 more
semanticscholar +1 more source