Results 1 to 10 of about 365,379 (338)
Methyltransferases of Riboviria
Biomolecules, 2022 Many viruses from the realm Riboviria infecting eukaryotic hosts encode protein domains with sequence similarity to S-adenosylmethionine-dependent methyltransferases.
Arcady Mushegian
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Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study
Biomolecules, 2021 The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines.
Sebastián Miranda-Rojas +4 more
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Histone H3K4 Methyltransferases as Targets for Drug-Resistant Cancers
Biology, 2021 The KMT2 (MLL) family of proteins, including the major histone H3K4 methyltransferase found in mammals, exists as large complexes with common subunit proteins and exhibits enzymatic activity.
Liu Yang, Mingli Jin, Kwang Won Jeong
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Frontiers in Bioengineering and Biotechnology, 2022 Kidamycins belong to the pluramycin family of antitumor antibiotics that contain di-C-glycosylated angucycline. Owing to its interesting biological activity, several synthetic derivatives of kidamycins are currently being developed.
Kyung Taek Heo +6 more
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Frontiers in Microbiology, 2022 Dichloromethane (DCM; CH2Cl2) is a widespread pollutant with anthropogenic and natural sources. Anaerobic DCM-dechlorinating bacteria use the Wood–Ljungdahl pathway, yet dechlorination reaction mechanisms remain unclear and the enzyme(s) responsible for ...
Sophie I. Holland +7 more
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Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury
Frontiers in Cell and Developmental Biology, 2022 Histone H3 lysine 4 (H3K4) methyltransferase 2D (KMT2D) plays an important role in cell development in early life. However, the function of KMT2D in adult cells such as cardiomyocytes or neurons has not been reported.
Shu-Bao Liu +6 more
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A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
Biomolecules, 2021 Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and
Iredia D. Iyamu +2 more
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Current Issues in Molecular Biology, 2023 Epigenetic studies on the role of DNA-modifying enzymes in HNSCC tumorigenesis have focused on a single enzyme or a group of enzymes. To acquire a more comprehensive insight into the expression profile of methyltransferases and demethylases, in the ...
Larisa Goričan +5 more
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Diagnostic, Therapeutic, and Prognostic Value of the m6A Writer Complex in Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) has poor prognosis and is usually diagnosed only at an advanced stage. Identification of novel biomarkers is critical to early diagnosis and better prognosis for HCC patients.
Zongting Gu +3 more
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Epigenetics, 2023 N6-Methyladenosine (m6A) plays key roles in the regulation of biological functions and cellular mechanisms for ischaemia reperfusion (IR) injury in different organs.
yongliang hua +11 more
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