Results 101 to 110 of about 339,003 (291)

Unusual vitamin E profile in the oil of a wild African oil palm tree (Elaeis guineensis Jacq.) enhances oxidative stability of provitamin A

Frontiers in Plant Science
IntroductionThe African oil palm (Elaeis guineensis Jacq.) is the predominant oil crop in the world. In addition to triacylglycerols, crude palm oil (CPO) extracted from the mesocarp of the fruits, contains high amounts of provitamin A (carotenes) and ...
Philipp Gutbrod, Delphine Pottier, Safoora Shirvani, Katharina Gutbrod, Félicité Djien-Nyami, Félicité Djien-Nyami, Raïssa Emade Ngoudjede, Raïssa Emade Ngoudjede, Georges Ngando-Ebongue, Georges Ngando-Ebongue, Peter Dörmann   +10 more
doaj   +1 more source

The genome and transcriptome of Trichormus sp NMC-1: insights into adaptation to extreme environments on the Qinghai-Tibet Plateau [PDF]

, 2016
The Qinghai-Tibet Plateau (QTP) has the highest biodiversity for an extreme environment worldwide, and provides an ideal natural laboratory to study adaptive evolution.
A Stamatakis, A Zorina, AL Delcher, B Langmead, BA Methé, C Xie, DA Los, DJ Wright, EP Balskus, G Blanc, G Norsang, HÄ Suh, J Qi, J Qi, J Zhang, JF Hess, JI Carreto, JM Shick, JP Zehr, K Mavromatis, KS Siddiqui, L Li, L R, L Ran, M Borodovsky, M Dassanayake, M Li, M Suyama, N Myers, P Pereira, P Puigbò, P Rajaniemi, PH Sudmant, PM Shih, Q Qiu, Q Tang, R Cavicchioli, RC Edgar, RL Tatusov, S Richter, SP Singh, SP Singh, SP Singh, T De Bie, T Kaneko, T Kogej, T Shi, U Consortium, U Nübel, WM Fitch, Z Xu, Z Yang, Z Yang, ZA Cheviron   +53 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Somatic mutations, DNA methylation, and expression of DNA repair genes in Arabidopsis thaliana treated with 5-azacytidine

Biologia Plantarum, 2019
An inhibitor of DNA methylation 5-azacytidine (5A) is a chemical analog of the nucleoside cytidine. This study investigated the influence of 5A-induced DNA hypomethylation on the accumulation of somatic DNA mutations (nucleotide substitutions, indels) in
K.V. Kiselev, Z.V. Ogneva, A.S. Dubrovina, N.N. Nityagovsky, A.R. Suprun   +4 more
doaj   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals

Current Research in Microbial Sciences
West Nile virus (WNV) is a flavivirus responsible for causing febrile illness and severe neurological diseases, with an increasing impact on human health around the world.
Alejandra Álvarez-Mínguez, Natalia del Río, Ana Belén-Blázquez, Elena Casanova, José-María Orduña, Patricia Camarero, Carolina Hurtado-Marcos, Carmen del Águila, María–Jesús Pérez-Pérez, Miguel A. Martín-Acebes, Rubén Agudo   +10 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Transcription factor NFYA3_0 promotes MTA-mediated m6A modification of PVY genomic RNA to confer antiviral resistance in Nicotiana benthamiana

Plant Communications
N6-methyladenosine (m6A), a reversible epigenetic modification, is ubiquitously present across diverse RNA species, including viral RNA. This modification plays a pivotal role in orchestrating RNA metabolism.
Jiao Li, Jianli Luo, Hongfu He, Fenyan Wang, Huan Wu, Chunni Zhao, Runjiang Song, Baoan Song   +7 more
doaj   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source