Results 111 to 120 of about 341,991 (305)

Phytoestrogens [PDF]

, 2004
Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H, Alekel DL, Bhathena SJ, Bielenberg J, Biendl M, Boller B, Dai Q, Day JK, de Kleijn MJJ, den Tonkelaar I, denTonkelaar I, Dewick PM, Ebisawa H, Fritz WA, Guo TL, Hodgson JM, Horn-Ross PL, ILDIS, Kim CS, Lamartiniere CA, Maggiolini M, Maskarinec G, McCann SE, Mentor MR, MerzDemlow BE, Newbold RR, Pan W, Peluso MR, Richard A. Dixon, Seested S, Setchell KDR, Setchell KDR, Setchell KDR, Slavin JL, Stevens JF, Whitten PL, Yanagihara K, Zhang Y   +37 more
core   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Unusual vitamin E profile in the oil of a wild African oil palm tree (Elaeis guineensis Jacq.) enhances oxidative stability of provitamin A

Frontiers in Plant Science
IntroductionThe African oil palm (Elaeis guineensis Jacq.) is the predominant oil crop in the world. In addition to triacylglycerols, crude palm oil (CPO) extracted from the mesocarp of the fruits, contains high amounts of provitamin A (carotenes) and ...
Philipp Gutbrod, Delphine Pottier, Safoora Shirvani, Katharina Gutbrod, Félicité Djien-Nyami, Félicité Djien-Nyami, Raïssa Emade Ngoudjede, Raïssa Emade Ngoudjede, Georges Ngando-Ebongue, Georges Ngando-Ebongue, Peter Dörmann   +10 more
doaj   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Somatic mutations, DNA methylation, and expression of DNA repair genes in Arabidopsis thaliana treated with 5-azacytidine

Biologia Plantarum, 2019
An inhibitor of DNA methylation 5-azacytidine (5A) is a chemical analog of the nucleoside cytidine. This study investigated the influence of 5A-induced DNA hypomethylation on the accumulation of somatic DNA mutations (nucleotide substitutions, indels) in
K.V. Kiselev, Z.V. Ogneva, A.S. Dubrovina, N.N. Nityagovsky, A.R. Suprun   +4 more
doaj   +1 more source

Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]

, 2018
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M, Bradley, Michelle C, Clarke, Catherine F, Fernández-Del-Río, Lucía, Nag, Anish, Tsui, Hui S   +5 more
core  

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme. [PDF]

, 2016
Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome ...
Fujimori, Danica Galonić, Noda-Garcia, Lianet, Stojković, Vanja, Tawfik, Dan S   +3 more
core  

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals

Current Research in Microbial Sciences
West Nile virus (WNV) is a flavivirus responsible for causing febrile illness and severe neurological diseases, with an increasing impact on human health around the world.
Alejandra Álvarez-Mínguez, Natalia del Río, Ana Belén-Blázquez, Elena Casanova, José-María Orduña, Patricia Camarero, Carolina Hurtado-Marcos, Carmen del Águila, María–Jesús Pérez-Pérez, Miguel A. Martín-Acebes, Rubén Agudo   +10 more
doaj   +1 more source