Results 131 to 140 of about 217,730 (262)

Repurposing methyltransferase-cofactor interactions for engineered microbial production of isotopically labelled SAM and SAH. [PDF]

Microb Cell Fact
Bulgakova UV, Rudenko AY, Karpenko IL, Vasil'ev VG, Sergiev PV, Dontsova OA, Polshakov VI, Mariasina SS.   +7 more
europepmc   +1 more source

The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle, Silvia Iñiguez‐Barrio, Maria Aurora Arrue, Leire Erkoreka   +3 more
wiley   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

Correction: Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach. [PDF]

Biochem J
Gray DW, Pearson LA, Petit AP, Mendoza-Martinez C, Bellany F, Lin, Niven S, Swift R, Eadsforth T, Fyfe PK, Paul M, Postis V, Hu X, Cowling VH.   +13 more
europepmc   +1 more source

Biosynthese des vollständig gesättigten C16‐Homosesquiterpens Descartan durch Deprotonierung mit Cyclopropanierung

Angewandte Chemie, EarlyView.
Eine nicht‐kanonische C16‐Sesquiterpensynthase aus Morganella morganii produziert das ungewöhnliche Grundgerüst Descartan. Ihr Cyclisierungsmechanismus wurde mittels Isotopenmarkierungsexperimenten und DFT‐Berechnungen aufgeklärt. Gezielte Mutagenese veränderte die Enzymfunktion und führte zu alternativen Produkten, darunter Voltairen, dessen ...
Kexin Yang, Philip Troycke, Bernd Goldfuss, Michael Groll, Jeroen S. Dickschat   +4 more
wiley   +1 more source

Identification and characterisation of an elusive bacterial enzyme system for chloromethane dehalogenation. [PDF]

Nat Commun
Bernhardt J, Hofmann LKR, Klemm P, Paczia N, Lemaire ON, Vuilleumier S, Wagner T, Kurth JM.   +7 more
europepmc   +1 more source

Recent Advances in Searching for DNMT Inhibitors and Their Potential Application in Treating Human Diseases. [PDF]

Int J Mol Sci
Bulygin AA, Davletgildeeva AT, Kuznetsov NA.   +2 more
europepmc   +1 more source

<i>O</i>-methyltransferase variation enables a specific volatile alarm call in rice. [PDF]

Sci Adv
Li H, Liu M, Chen Y, Jin G, Wang L, Liu S, Shang L, Gershenzon J, Baldwin IT, Li R.   +9 more
europepmc   +1 more source

MPore: database-driven identification of active methyltransferases in prokaryotic genomes from nanopore sequencing. [PDF]

Bioinform Adv
Nisar A, Vogelgsang L, Fuchs S, Pfeffer K, Henrich B, Dilthey A.   +5 more
europepmc   +1 more source

A Golgi-localized N-methyltransferase and reversible aldo-keto reductases coordinate dual terminal routes in galanthamine biosynthesis. [PDF]

Plant J
Lamichhane B, Niraula A, Merindol N, Gélinas SE, Lagüe P, Ricard S, Germain H, Desgagné-Penix I.   +7 more
europepmc   +1 more source