Results 151 to 160 of about 292,501 (293)

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

Advanced Science, EarlyView.
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu, Zhenbo Yuan, Yue Gao, Fei Li, Zhiwei Deng, Yan Zhang, Zhengshan Luo, Changmei Liu, Yijian Rao   +8 more
wiley   +1 more source

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

Oncogene, 2019
M. Cheng, L. Sheng, Q. Gao, Q. Xiong, Haojie Zhang, Mingqing Wu, Yu Liang, Fengyu Zhu, Yingyin Zhang, Xiuhong Zhang, Q. Yuan, Yang Li   +11 more
semanticscholar   +1 more source

Faculty Opinions recommendation of Site-specific RNA methylation by a methyltransferase ribozyme.

, 2020
Stephanie Kath‐Schorr
openalex   +2 more sources

Data from Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells

, 2023
Hao‐Chen Wang, Chin-Wang Chen, Chia-Lung Yang, I-Min Tsai, Ya‐Chin Hou, Chang-Jung Chen, Yan‐Shen Shan   +6 more
openalex   +1 more source

Extracellular Vesicle‐Packaged circTAX1BP1 from Cancer‐Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells

Advanced Science, EarlyView.
This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan, Jin‐hao Yu, Dong Hou, Ye‐quan Xie, Dong‐ming Lai, Fang Zheng, Bin Yang, Jin‐tao Zeng, Yang Chen, Shu‐hong Lu, Guang‐yu Zhong, Fang‐hai Han, Sheng‐ning Zhou   +12 more
wiley   +1 more source

Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp.

, 2008
Malcolm S. Buchanan, Anthony R. Carroll, Gregory A. Fechner, Anthony Boyle, Moana Simpson, Rama Addepalli, Vicky M. Avery, John N. A. Hooper, Tony Cheung, Huwei Chen, Ronald J. Quinn   +10 more
openalex   +1 more source

Additional file 9 of Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

, 2023
Vanessa Ortiz-Barahona, Marta Soler, Verónica Dávalos, Carlos A. García‐Prieto, Maxime Janin, Fernando Setién, Irene Fernández-Rebollo, Joan Josep Bech‐Serra, Carolina de la Torre, Sònia Guil, Alberto Villanueva, Peihong Zhang, Yang Li, Marco Guarnacci, Ulrike Schümann, Thomas Preiß, Ugne Balaseviciute, Robert Montal, Josep M. Llovet, Manel Esteller   +19 more
openalex   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source

Evolutionary Divergence of an Ethylene‐Responsive Transcriptional Cascade Governs a Dose‐Dependent Balance between Cotton Fiber Length and Strength

Advanced Science, EarlyView.
A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang, Mengli Yu, Yuling Guo, Jie Li, Gailing Gu, Ghulam Hussain, Shuya Ma, Fuguang Li, Hongwei Xue, Zhaoen Yang, Zuoren Yang   +10 more
wiley   +1 more source

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Nature Chemical Biology, 2018
Honghui Ma, Honghui Ma, Honghui Ma, Xiaoyun Wang, Jia-Bing Cai, Qing Dai, Qing Dai, S. K. Natchiar, Ruitu Lv, Kai Chen, Kai Chen, Zhike Lu, Zhike Lu, Hao Chen, Y. Shi, Y. Shi, F. Lan, Jia Fan, B. Klaholz, Tao Pan, Yang Shi, Yang Shi, Chuan He, Chuan He   +23 more
semanticscholar   +1 more source