Results 171 to 180 of about 292,501 (293)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Isolation and Characterization of Two Methyltransferase Genes, AfuvipB and AfuvipC in Aspergillus fumigatus

, 2015
Mohammed A. Abdo Elgabbar, Kap‐Hoon Han   +1 more
openalex   +1 more source

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands [PDF]

, 2011
Heather M. O’Hagan, Wei Wang, Subhojit Sen, Christina E. DeStefano Shields, Stella S. Lee, Yang W. Zhang, Eriko G. Clements, Yi Cai, Leander Van Neste, Hariharan Easwaran, Robert A. Casero, Cynthia L. Sears, Stephen B. Baylin   +12 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Inhibition of monkeypox polymerase holoenzyme and methyltransferase using bioactive compounds of black tea: a computational approach. [PDF]

Sci Rep
Mumtaz M, Khan K, Khan A, Rashid HU, Jan AU, Shah T, Ahmad N.   +6 more
europepmc   +1 more source

EFFECT OF VAL158MET CATECHOLAMINE O-METHYLTRANSFERASE GENE POLYMORPHISM ON INTERHEMISPHERIC ASYMMETRY IN ANTISACCADE TASK

, 2019
A. V. Kirenskaya, M. A. Gruden, Vladimir Y. Novototsky‐Vlasov, Alexandra Ryabova, З. И. Сторожева   +4 more
openalex   +1 more source

Peer Review #1 of "Role of methyltransferase-like enzyme 3 and methyltransferase-like enzyme 14 in urological cancers (v0.2)"

, 2020
Zijia Tao, Yiqiao Zhao, Xiaonan Chen, Xiaonan Chen   +3 more
openalex   +1 more source

H3K9 methyltransferase G9a and the related molecule GLP [PDF]

, 2011
Yoichi Shinkai, Makoto Tachibana
openalex   +1 more source

In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation

Advanced Science, EarlyView.
Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...
Yichi Chen, Yijun Wang, Haitao Shang, Jiayue Qiu, Ruotian Zhang, Yuxiang Xiong, Tong Wang, Fengyi Wang, Anbang Wu, Xin Lin, Bolin Wu, Chen Huang, Wen Cheng, Lu Zhang   +13 more
wiley   +1 more source

Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition [PDF]

, 2016
Chaochen Wang, Ji‐Eun Lee, Binbin Lai, Todd S. Macfarlan, Shiliyang Xu, Lenan Zhuang, Chengyu Liu, Weiqun Peng, Kai Ge   +8 more
openalex   +1 more source