Results 171 to 180 of about 339,003 (291)

Enzymatic Synthesis of Demethylated Sesquiterpenes From 14‐nor‐Farnesyl Pyrophosphate

European Journal of Organic Chemistry, EarlyView.
The substrate analog 14‐nor‐FPP was synthesised and enzymatically converted with 10 bacterial and fungal sesquiterpene synthases, resulting in the isolation of 12 demethylated sesquiterpenes in yields up to 17%. In most cases the demethyl analogs of the FPP‐derived natural products were obtained, but also different products showing modified ...
Kizerbo A. Taizoumbe, Jeroen S. Dickschat   +1 more
wiley   +1 more source

Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates of <i>Borrelia afzelii</i> and <i>Borrelia garinii</i>. [PDF]

Curr Res Microb Sci
Ruivo M, Schötta AM, Stelzer T, Reiter M, Wijnveld M.   +4 more
europepmc   +1 more source

Enhancing plant antiviral responses and productivity through the elimination of m⁵C methyltransferase. [PDF]

Sci Adv
Jiang Y, Liu P, Zhang M, Yong B, Yin J, Chen L, Shi C, Li P, Guo Y, Hu H, Feng L, Chen L, Zhang T, Liu J, Zhong K, Zhou X, Chen F, Chen J, Yang J.   +18 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Wheat DNA Methyltransferase TaMET1 Negatively Regulates Salicylic Acid Biosynthesis to Facilitate Powdery Mildew Susceptibility. [PDF]

J Fungi (Basel)
Ge P, Chen W, Liu J, Wang X, Chang C.
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

HPD is an m⁶A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m⁶A Methylating SLC7A11/GPX4. [PDF]

Adv Sci (Weinh)
Wang J, Dai X, Liu H, Hua S, Chang H, Sun H, Sun M, Zhao H, Ni K, Xie F, Qiao Y, Gao Q, Yu C, Zhang Q, Guo J, Zhang C, Zhang S, Shan C.   +17 more
europepmc   +1 more source

DNA Methyltransferase [PDF]

, 2020
openaire   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, EarlyView.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source