Results 181 to 190 of about 341,991 (305)

Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM. [PDF]

J Biol Chem
Konttinen O, Dangerfield T, Vargas J, Johnson KA, Reich N.   +4 more
europepmc   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Optimized Bioconversion of Naringenin to Hesperetin in <i>Escherichia coli</i> With Halide Methyltransferase-Mediated <i>S</i>-Adenosylmethionine Regeneration. [PDF]

Eng Life Sci
Wildhagen M, Malke N, Wang Q, Zhuang X, Beutel S.   +4 more
europepmc   +1 more source

Partial Purification and Properties of S-Adenosylmethionine. (R), (S)-Norlaudanosoline-6-O-Methyltransferase from Eschscholtzia tenuifolia Cell Cultures [PDF]

, 1983
Nagakura, Naotaka, Rüffer, Martina, Schumacher, H. M., Zenk, Meinhart H.   +3 more
core  

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

Structure-Based Drug Discovery of Non-SAM-Mimetic Bisubstrate Inhibitors against Nicotinamide <i>N</i>‑Methyltransferase. [PDF]

ACS Med Chem Lett
Yoshida S, Kondo N, Uehara S, Yoshimura N, Sako Y, Yamamoto S, Kitade M, Tachibana Y.   +7 more
europepmc   +1 more source

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Evolutionary and Functional Characterization of an Auxin Methyltransferase (<i>CsIAMT</i>) in Cucumber Reveals Its Role in Stress Adaptation and Development. [PDF]

Ecol Evol
Zhang X, Zhou Y, Chen M, Li J, Jiang L, Li K, Hao L, Fu W.   +7 more
europepmc   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

<i>FTSJ1</i>-mediated <i>IL1RN</i> mRNA instability promotes inflammation-driven hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Jiang S, Ding D, Zu Y, Liao Y, Wang T, Yu J, Zhou W, Yuan S.   +7 more
europepmc   +1 more source