Results 191 to 200 of about 217,730 (262)

The Rare RNA Methylations m²G, Cm, m⁵U and ms²i⁶A: Roles in Disease Pathogenesis and Emerging Therapeutic Implications. [PDF]

Int J Med Sci
Wan K, Nie T, Zhang Q, Huang Y, Bian J, Min J.   +5 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS. [PDF]

FASEB J
Weng Y, Shangguan L, Shen Q, Zhu Z, Zhang Y, Zhang J, Yan G, Shen S, Xiang Z, Ruan J, Wen Y, Wang D, Wang Y.   +12 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

RNA methylation in autoimmune rheumatic diseases: mechanisms and therapeutic potential. [PDF]

Front Immunol
Wang Y, Song G, Xue Y, Li X, Cheng S, Liu M, Liu H, Pan J, Zhao H, Liu B, Fan D.   +10 more
europepmc   +1 more source

DNA Methyltransferases [PDF]

, 2011
openaire   +1 more source

Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin, Dong Keon Kim, Yoojeong Seo, Hyeon Hee Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Jongwon Oh, Sanghoo Lee, Tae Il Kim   +10 more
wiley   +1 more source

Clinical immunology in chromatinopathies: a scoping review. [PDF]

Front Immunol
Jans D, Al B, Bouman A, Geelen JM, Kleefstra T, Placek K.   +5 more
europepmc   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G. [PDF]

Exp Mol Med
Wang Z, Zhao J, Luo W, Sun N, Ma X, Zhong F, Wu B, Tang H, Ning K, He J, Wang X, Zhang K, Zhang J, Liu C, Ren J, Zhao Y, Qin Z.   +16 more
europepmc   +1 more source