Results 201 to 210 of about 217,730 (262)
METTL5 reprograms glycolytic metabolism and promotes non-small cell lung cancer progression by modifying PGAM1. [PDF]
Oncol LettShan Y +5 more
europepmc +1 more source
m6A Methyltransferase METTL3 Regulates Inflammatory and Immune Microenvironments in Renal Cell Carcinoma via Modulation of the PI3K/AKT Pathway. [PDF]
Int J GenomicsCheng T +7 more
europepmc +1 more source
The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation. [PDF]
J Biol ChemMichail C +20 more
europepmc +1 more source
Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis. [PDF]
Hepatol CommunÁngel-Gomis E +8 more
europepmc +1 more source
The methyltransferase METTL16 in digestive system cancers: functions and mechanisms. [PDF]
Front OncolLi J, Bao Y, Yao F, Wu Q.
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Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
Richard Weinshilboum +2 more
exaly +3 more sources
▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
Richard Weinshilboum +2 more
exaly +3 more sources
Canadian Journal of Biochemistry and Physiology, 1963
The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
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The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
openaire +2 more sources
Current Opinion in Cell Biology, 1994
Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
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Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
openaire +2 more sources