Results 221 to 230 of about 341,991 (305)

Harnessing Methyltransferase-Guided Targeting for Sequence-Specific Proximity Labeling of DNA. [PDF]

Angew Chem Int Ed Engl
Chen X, Wen G, Ooghe N, Abakumov S, Rohand T, Leen V, Dedecker P, Weil T, Hofkens J.   +8 more
europepmc   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Assembling Ternary Dead-End Complex for Covalent Trapping of Protein Lysine Methyltransferases. [PDF]

J Am Chem Soc
Zong Y, Zhang N, Lin J, Li Z, Zou Y, Chaudhuri R, Luo M.   +6 more
europepmc   +1 more source

Insect‐resistant soybean genotypes accumulate rutin and its O‐methylated derivative narcissin, a more potent flavonol targeting Anticarsia gemmatalis digestive and detoxification enzymes and reducing larval survival

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Soybean underpins Brazil's agricultural, yet its sustainability is threatened by lepidopteran pests such as Anticarsia gemmatalis. Although insect‐resistant cultivars have long been associated with the constitutive accumulation of quercetin‐derived flavonols, the biochemical mechanisms underlying this resistance remain poorly ...
Jessica Nunes de Assis, Valquira Joana Medina Pinheiro, Jodieh Oliveira Santana Varejão, Ian de Paula Alves Pinto, André Luiz Lourenção, Nathália Silva Oliveira, Giovanna Cassia Mendes Moraes, Eduardo Vinícius Vieira Varejão, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +9 more
wiley   +1 more source

The promoting role of protein arginine methyltransferase 1 in cervical cancer: Mechanisms of angiogenesis and immune evasion. [PDF]

Cytojournal
Wang X, Zheng X, Fang Y, Zheng T, Zhang J, Li Z, Hou Y.   +6 more
europepmc   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

Epigenetic Disruption as a Molecular Signature in Idiopathic Nonobstructive Azoospermia. [PDF]

Am J Mens Health
Firouzabadi AM, Harimi S, Heydari P, Demehri F, Mirghanizadeh Bafghi SAH, Fesahat F.   +5 more
europepmc   +1 more source

PRMT5 Mediates Sepsis‐Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung injury is a common complication in critical sepsis. PRMT5 is implicated in endothelial inflammation and lung diseases, but its role in sepsis‐associated lung injury remains unclear. This study collected clinical sepsis samples and detected the mRNA expression of PRMT5.
Bo Wang, Zhen Ge, Fei‐Xiang Chen
wiley   +1 more source

The EP424R protein of African swine fever virus functions as a 2'-O-methyltransferase and plays an important role in viral replication. [PDF]

mBio
Wang Z, Guo F, Wang X, Cheng L, Liu Y, Guo Y, Niu S, Baghaei Daemi H, Peng G.   +8 more
europepmc   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source