Results 241 to 250 of about 341,991 (305)
Common genetic polymorphisms define one-carbon metabolite responses to different forms of choline in healthy adult males. [PDF]
Front NutrButt N +6 more
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METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells. [PDF]
Transl Cancer ResZeng X +7 more
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Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
Richard M Weinshilboum
exaly +3 more sources
▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
Richard M Weinshilboum
exaly +3 more sources
Canadian Journal of Biochemistry and Physiology, 1963
The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
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The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase,
J, BLUMENSTEIN, G R, WILLIAMS
openaire +2 more sources
Current Opinion in Cell Biology, 1994
Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
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Mammals have long been known to tag their DNA by the addition of methyl groups to cytosine residues. Only quite recently, however, has the functional significance of DNA methylation established a firm footing. Evidence now indicates that DNA methylation is essential for development, and is involved in both programmed and ectopic gene inactivation ...
T H, Bestor, G L, Verdine
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Enzymology, 1968
An enzyme that transfers the methyl group of S-adenosylmethionine to phenol to form anisole is described. The enzyme is highly localized in the microsomes of the liver and lung of mammals and is also present in other tissues. A variety of simple alkyl-, methoxy- and halophenols can serve as substrates for the phenol-O-methylating enzyme.
J, Axelrod, J, Daly
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An enzyme that transfers the methyl group of S-adenosylmethionine to phenol to form anisole is described. The enzyme is highly localized in the microsomes of the liver and lung of mammals and is also present in other tissues. A variety of simple alkyl-, methoxy- and halophenols can serve as substrates for the phenol-O-methylating enzyme.
J, Axelrod, J, Daly
openaire +2 more sources
EUKARYOTIC CYTOSINE METHYLTRANSFERASES
Annual Review of Biochemistry, 2005▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylation does not reinforce or replace ancestral gene regulation pathways but instead endows methylated genomes with the ability to repress specific promoters in a manner that is ...
Mary Grace, Goll, Timothy H, Bestor
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